A5024747340- Growth Hormone and Insulin-like Growth Factors
- MicroRNA in disease regulation
- Stress Responses and Cortisol
- Malaria Research and Control
- Celiac Disease Research and Management
- Lung Cancer Diagnosis and Treatment
- Hypothalamic control of reproductive hormones
- Birth, Development, and Health
- Microscopic Colitis
- Alcoholism and Thiamine Deficiency
- Estrogen and related hormone effects
- Insect Resistance and Genetics
- Lung Cancer Treatments and Mutations
- Helicobacter pylori-related gastroenterology studies
- Tracheal and airway disorders
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Pituitary Gland Disorders and Treatments
- Pleural and Pulmonary Diseases
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Treatments and Studies
- Complement system in diseases
- Radiomics and Machine Learning in Medical Imaging
- Thyroid Disorders and Treatments
- Aquaculture Nutrition and Growth
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2021-2023
Manhiça Health Research Centre
2021
London School of Hygiene & Tropical Medicine
2021
Universitat de Barcelona
1972-2021
Hospital Sant Joan de Déu Barcelona
2021
Hospital Clínico San Carlos
1991-2021
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2021
Barcelona Institute for Global Health
2016-2020
Institut de Biologia Evolutiva
2011-2018
Universitat Pompeu Fabra
2013
Background microRNAs (miRNAs) have been reported as key regulators at post-transcriptional level in eukaryotic cells. In insects, most of the studies focused holometabolans while only recently two hemimetabolans (Locusta migratoria and Acyrthosiphon pisum) had their miRNAs identified. Therefore, study evolutionarily basal hemimetabolan Blattella germanica may provide valuable insights on structural functional evolution miRNAs. Methodology/Principal Findings Small RNA libraries cockroach B....
Circulating small RNAs, including miRNAs but also isomiRs and other RNA species, have the potential to be used as non-invasive biomarkers for communicable non-communicable diseases. This study aims characterize compare profiles in human biofluids. For this purpose, was extracted from plasma breast milk samples 15 healthy postpartum mothers. Small libraries were prepared with NEBNext® library preparation kit sequenced an Illumina HiSeq2000 platform. miRNAs, clusters of RNAs annotated using...
Abstract Background Previous work showed that miRNAs play key roles in the regulation of metamorphosis hemimetabolan species Blattella germanica . To gain insight about which might be important, we have constructed two miRNA libraries, one penultimate, pre-metamorphic nymphal instar (N5) and other last, metamorphic (N6). Results High throughput sequencing gave 61 canonical present N5 N6 although at different proportions each. Comparison both libraries led to identification three 37...
Cytoadhesion of Plasmodium falciparum infected erythrocytes to gC1qR has been associated with severe malaria, but the parasite ligand involved is currently unknown. To assess if binding mediated through P. erythrocyte membrane protein 1 (PfEMP1) family, we analyzed by static assays and qPCR cytoadhesion var gene transcriptional profile 86 isolates from Mozambican children uncomplicated as well a 3D7 line selected for (Pf3D7gC1qR). Transcript levels DC8 correlated positively (rho = 0.287, P...
Severe malaria (SM) is a major public health problem in malaria-endemic countries. Sequestration of Plasmodium falciparum-infected erythrocytes vital organs and the associated inflammation leads to organ dysfunction. MicroRNAs (miRNAs), which are rapidly released from damaged tissues into host fluids, constitute promising biomarker for prognosis SM. We applied next-generation sequencing evaluate differential expression miRNAs SM uncomplicated (UM) children Mozambique. Six were with vitro P....
The gametocytes of Plasmodium falciparum, responsible for the transmission this malaria parasite from humans to mosquitoes, accumulate and mature preferentially in human bone marrow. In 10 day long sexual development P. immature reach localize extravascular compartment organ, contact with several marrow stroma cell types, prior traversing endothelial lining re-entering circulation at maturity. To investigate host interplay underlying still obscure process, we developed an vitro...
At our laboratory, we have recently demonstrated the immunohistochemical expression of aromatase P450 in pituitary glands adult rats; this was seen to be sex-dependent. In order determine whether changes enzyme are related gonadal sphere and is postnatal differentiation hypophyseal cytology, present work performed an study rat gland from birth old age. The reaction evident very generalized at 7 days after birth, with no large differences between male female animals. 14 decreased females,...
Abstract Background The diagnosis of coeliac disease (CD) in individuals that have started a gluten-free diet (GFD) without an adequate previous diagnostic work-out is challenge. Several immunological assays such as IFN-γ ELISPOT been developed to avoid the need prolonged gluten challenge induce intestinal damage. We aimed evaluate accuracy activated gut-homing CD8 + and TCRγδ T cells blood after 3-day compare it with performance HLA-DQ2.5 subsample. Methods A total 22 CD patients 48 non-CD...
124 specimens of Lophius piscatorius , L. have been studied (22 males, 90 immature females and 12 sexually mature females) from the Mediterranean coast between October 1968 February 1971. The plasma values total proteins, Cl ‐ K + Na iron, iron binding capacity copper determined. These are related to weight, length, sex sexual maturity, depth trawl season year. electrolyte content is somewhat lower than given for this species. A clear seasonal variation observed, with a decrease in...