A5085423860- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Receptor Mechanisms and Signaling
- Microbial Natural Products and Biosynthesis
- Global Cancer Incidence and Screening
- Fungal Biology and Applications
- AI in cancer detection
- Plant Pathogens and Fungal Diseases
- Computational Drug Discovery Methods
- Renal and related cancers
- Histone Deacetylase Inhibitors Research
- Renal cell carcinoma treatment
- Machine Learning in Bioinformatics
- Colorectal Cancer Screening and Detection
- Protein Structure and Dynamics
- Pharmacological Receptor Mechanisms and Effects
- Genetic and Kidney Cyst Diseases
- Pancreatic function and diabetes
- Enzyme Structure and Function
- Cancer-related gene regulation
- Pharmacogenetics and Drug Metabolism
- Cancer Research and Treatments
Jordan University of Science and Technology
2023-2024
University of North Carolina at Greensboro
2018-2020
Medicina
2016
Background: The glyoxalase system including two thiol-dependent enzymes, I (Glo-I) and II, plays an important role in a ubiquitous metabolic pathway involved cellular detoxification of cytotoxic 2-oxoaldehydes. Tumor cells have high glycolytic activity, leading to increased levels these toxic metabolites. activity the cancerous makes this viable target for developing novel anticancer agents. In study, we examined potential utility non-glutathione-based inhibitors Glo-I enzyme as drugs....
Globally, breast cancer (BC) is the most commonly detected neoplasm in women. Breast self-examination (BSE) an effective screening technique that enables women to learn about composition of their breasts and assist early identification any potential abnormalities.
Wheldone (1) was isolated and elucidated from a coculture of Aspergillus fischeri (NRRL 181) Xylaria flabelliformis (G536), where secondary metabolite biosynthesis stimulated by antagonism between these fungi. First observed via in situ analysis competing fungal cultures, the conditions were scaled to reproducibly generate 1, whose novel structure one- two-dimensional NMR mass spectrometry. Compound 1 displayed cytotoxic activity against breast, ovarian, melanoma cancer cell lines.
Background: Over the past decade, transcriptome profiling has elucidated many pivotal pathways involved in oncogenesis. However, a detailed comprehensive map of tumorigenesis remains an enigma to solve. Propelled research been devoted investigating molecular drivers clear cell renal carcinoma (ccRCC). To add another piece puzzle, we evaluated role anoctamin 4 (ANO4) expression as potential prognostic biomarker non-metastasized ccRCC. Methods: A total 422 ccRCC patients with corresponding...
GPR6 is an orphan G protein-coupled receptor that has been associated with the cannabinoid family because of its recognition a sub-set ligands. The high abundance in central nervous system, along constitutive activity and link to several neurodegenerative diseases make promising biological target. In fact, diverse research groups have demonstrated represents possible target for treatment disorders such as Parkinson’s disease, Alzheimer’s Huntington’s disease. Several patents claimed use wide...
The orphan G protein coupled receptor 6 (GPR6) is a cannabinoid-related Class A GPCR. It highly expressed in the central nervous system and exhibits high constitutive activation of adenylyl cyclase. Several research groups have demonstrated that GPR6 represents possible target for treatment neurodegenerative disorders such as Parkinson's, Alzheimer's, Huntington's diseases. patents claim use wide range pyrazine derivatives inverse agonists Parkinson's disease other dyskinesia syndromes....