A5069585143- Pluripotent Stem Cells Research
- Congenital heart defects research
- CRISPR and Genetic Engineering
- Tissue Engineering and Regenerative Medicine
- Epigenetics and DNA Methylation
- Renal and related cancers
- Neuroscience, Education and Cognitive Function
- Animal Genetics and Reproduction
- Cancer-related gene regulation
- Developmental Biology and Gene Regulation
The University of Sydney
2019-2025
Children's Medical Research Institute
2019-2025
University of Cambridge
2024
University of Oregon
1947
Summary A population of putative mesendoderm progenitor cells that can contribute cellular descendants to both mesoderm and endoderm lineages is identified. These are localized the anterior primitive streak adjacent epiblast E7.0-E7.5 mid-to late-gastrula stage embryos. Lineage tracing in vivo revealed progenitors marked by Mixl1 Mesp1 activity layer. Analysis role transcription factor differentiation mouse stem choice for or cell fate depends on timing activation upon exit from...
The specification of anterior head tissue in the late gastrulation mouse embryo relies on signaling cues from visceral endoderm and mesendoderm (AME). Genetic loss-of-function studies have pinpointed a critical requirement LIM homeobox 1 (LHX1) transcription factor these tissues for formation embryonic head. Transcriptome analysis embryos with gain-of-function LHX1 activity identified forkhead box gene, Foxd4, as one downstream target late-gastrulation E7.75 embryos. Our single-cell RNA-seq...