A5101482233- Antibiotic Resistance in Bacteria
- Infections and bacterial resistance
- Bacterial Identification and Susceptibility Testing
- Antibiotics Pharmacokinetics and Efficacy
- 3D Surveying and Cultural Heritage
- Mycobacterium research and diagnosis
- Electromagnetic Fields and Biological Effects
- Bacterial Genetics and Biotechnology
- Synthesis and Biological Evaluation
- Heavy Metal Exposure and Toxicity
- Enterobacteriaceae and Cronobacter Research
- Retinoids in leukemia and cellular processes
- Diet and metabolism studies
- Cancer therapeutics and mechanisms
- Ginseng Biological Effects and Applications
- Lung Cancer Research Studies
- Bacterial biofilms and quorum sensing
- Robotics and Sensor-Based Localization
- Hepatitis C virus research
- Phytochemistry and biological activity of medicinal plants
- Pharmaceutical and Antibiotic Environmental Impacts
- Tryptophan and brain disorders
- Pharmacological Effects of Natural Compounds
- Vibrio bacteria research studies
- Cancer, Stress, Anesthesia, and Immune Response
Wenzhou Medical University
2018-2022
Lishui Central Hospital
2010-2020
Center for Disease Control
2020
Lishui University
2018
Zhejiang University
2018
Beijing University of Chinese Medicine
2015
82th Hospital of Pla
2005
Methods to improve the bioactive component content of cultivated licorice have become bottleneck industrial extraction for pharmaceutical use. To evaluate effects genotype, environment and their interaction on major components, we analyzed five components: liquiritin (LQ), liquiritigenin (LQG), glycyrrhizin (GL), isoliquiritin (ILQ) isoliquiritigenin (ILQG) four diverse varieties grown in distinct environments northern China during 2010-11. Analysis variance showed that environmental...
Two basic structures that carry the blaKPC gene, Tn4401 transposon and Tn3-Tn4401 chimera, have been identified within outside China. However, different expression levels promoter activities of these two are not completely understood. We constructed Tn4401a, Tn4401b, chimera recombinants found imipenem (IPM) meropenem (MEM) MICs for Escherichia coli transformants carrying were 2-fold higher than those Tn4401b but lower Tn4401a In addition to P1, we characterized a novel potential sequence...
The wide spread of Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae is great threat to public health in China. Plasmids are among the major factors mediating blaKPC gene dissemination. A total 156 carbapenem-resistant (CRE) isolates were identified a tertiary hospital Six KPC-producing isolates, namely, E. coli (n = 2), asburiae 1), C. freundii portucalensis and koseri tested positive for pCKPC18-1-like untypeable plasmid, which was described recently freundii. All 6...
Introduction. Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a major cause of clinical infection. However, K. carbapenemase (KPC)-producing ST15 strains are occasionally identified and have seldom been reported to hospital outbreaks in PR China.Hypothesis/Gap Statement. In this study, we describe nosocomial caused by KPC-producing Chinese tertiary hospital.Aim. To characterize the molecular relationship, resistance virulence factors 32 isolated hospital.Methodology. A total 102...
The expression of the blaKPC gene plays a key role in carbapenem resistance Enterobacteriaceae However, genetic regulators have not been completely elucidated, especially genes Tn3-Tn4401 chimeras. Two novel chimera isoforms were characterized our hospital, isoform A (CTA), which harbors 121-bp deletion containing PX promoter and was present 22.6% (54/239) isolates, C (CTC), 624-bp insertion P1 only 1 isolate. MICs both 2-fold or more higher than those wild type (Tn3-Tn4401 chimera, CTB),...
Introduction. Members of the genus Citrobacter are facultative anaerobic Gram-negative bacilli belonging to Enterobacterales [Janda J Clin Microbiol 1994; 32(8):1850–1854; Arens Infect 1997;3(1):53–57]. Formerly, species were occasionally reported as nosocomial pathogens with low virulence [Pepperell Antimicrob Agents Chemother 2002;46(11):3555–60]. Now, they consistently cause infections urinary tract, respiratory bone, peritoneum, endocardium, meninges, intestines, bloodstream and central...
Abstract Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a major cause of clinical infection. However, KPC-producing K. ST15 strains are occasionally identified and have never been reported to hospital outbreaks in China. Methods In this study, pulsed-field gel electrophoresis (PFGE) whole-genome sequencing (WGS) were used characterize 32 strains, which collected at Chinese tertiary hospital. Susceptibilities, resistance genes, virulence factors performances the comparatively...