A5032828193- Birth, Development, and Health
- Fatty Acid Research and Health
- Antioxidant Activity and Oxidative Stress
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Adipose Tissue and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Obesity, Physical Activity, Diet
- Retinoids in leukemia and cellular processes
- Infant Nutrition and Health
- Lipid metabolism and disorders
- Phytochemicals and Antioxidant Activities
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism and Genetic Disorders
- Hormonal and reproductive studies
- Cancer, Lipids, and Metabolism
- Nutritional Studies and Diet
- Digestive system and related health
- Natural Antidiabetic Agents Studies
- Lipid metabolism and biosynthesis
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Lipoproteins and Cardiovascular Health
- Folate and B Vitamins Research
- Vitamin C and Antioxidants Research
Universidad San Pablo CEU
2013-2025
Hospital Universitario Ramón y Cajal
1999-2015
Centro de Investigación Biomédica en Red
2014
Universidad de Alcalá
1998-2009
Universidad Autónoma de Madrid
2001-2009
Universitat de València
2009
Instituto de Fermentaciones Industriales
2006
Universidad San Pablo
2004-2005
Hospital Universitario Fundación Jiménez Díaz
2001-2005
Clínica Rementería
2002
To evaluate the potential contribution of maternal glucose and lipids to fetal metabolic variables growth in pregnancies with normal tolerance comparison well-controlled gestational diabetes previously reported by us.In 190 oral tests (controls), insulin, lipid components were determined arterial cord blood serum. Birthweight neonatal fat mass obtained after delivery. Values adjusted for pre-pregnancy BMI, Caesarean section age. Measurements compared those reported.Maternal serum glucose,...
Whereas accumulation of fat depots occurs during the first two-thirds gestation, increased adipose tissue lipolysis and hyperlipidemia develops in last trimester. Insulin resistance estrogens late pregnancy contribute to these changes. Lipoprotein receptors fatty acid binding proteins placenta allow transfer long-chain polyunsaturated acids fetus. Enhanced oxidative stress may be related maternal hyperlipidemia. Maternal plasma nonesterified cholesterol correlate with those fetus,...
OBJECTIVE To determine the concentrations of adipocyte fatty acid–binding protein (AFABP) and other adipocytokines in maternal cord serum pregnant women with gestational diabetes mellitus (GDM) control subjects to relate them indexes insulin sensitivity. RESEARCH DESIGN AND METHODS In 86 98 GDM women, venous blood was collected before vaginal delivery arterial from immediately after delivery. Serum were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS had higher prepregnancy...
ABSTRACT A diet rich in lipids can lead to many deleterious conditions, which involve regulatory molecules, such as non‐coding (nc)RNAs. We aimed analyze the effects of high dietary lipid exposure on expression intestinal ncRNAs (long [lncRNAs] and circular [circRNAs]). lncRNAs circRNAs were screened, both vivo (mice) vitro (human organoids). In vivo, 15 (9 up‐ 6 downregulated) 41 (13 28 modulated 3 h after a challenge, while 11 (4 7 was altered 4 days daily high‐fat intake. vitro, 251 387...
Abstract Context: Obesity and diabetes during pregnancy are associated with increased insulin resistance higher neonatal adiposity. In turn, triggers inflammatory pathways accumulation of placental cytokines. Objective: To determine signals that translate into development excess adipose tissue, we investigated the role phospholipases A2 (PLA2) as targets mediators. Setting: The study was conducted at Case Western Reserve University, Department Reproductive Biology. Subjects: Volunteers gave...
Neonates of women with gestational diabetes mellitus (GDM) have reduced levels arachidonic acid (AA) (20:4 n-6) and docosahexaenoic (DHA) (22:6 n-3). To assess whether this is the result impaired placental transfer or endogenous fetal metabolism, fatty acids in umbilical venous arterial plasma were analyzed neonates GDM women.Fatty by gas chromatography 15 subjects 30 healthy control undergoing elective cesarean section vein artery cord blood collected separately.The percentages AA n-6), DHA...
Abstract This article reports cross‐sectional data from a total of 1048 children, 6 to 8 years age, categorized by presence or absence obesity, who participated in voluntary survey cardiovascular risk factors Spain over the period 1998 2000, establish relationship between obesity and its metabolic consequences at this age. The prevalence overweight were 9.4% 15.7%, respectively, boys 10.5% 18.0%, girls. We observed that, both sexes, obese children had higher triglycerides lower high‐density...
Angiopoietin-like protein 4 (ANGPTL4) is an extracellular inhibitor of lipoprotein lipase (LPL) activity. No studies have been done in pregnancy which hypertriglyceridemia and tissue-specific changes LPL activity are present. The objective the study was to determine relationship between neonatal fat mass (FM) concentrations ANGPTL4 triacylglycerols (TAG) maternal cord serum pregnant women with gestational diabetes mellitus (GDM) compared controls. Maternal blood samples (control, n = 90,...
IUGR (intrauterine growth restriction) increases the incidence of perinatal complications and, although several placental transport functions have been shown to be altered in pregnancies complicated by IUGR, mechanism behind it is not well understood. The aim present study was investigate factors maternal and cord blood plasma from normal IUGR-complicated associated with body weight newborns. At time Caesarean section, 24 women were compared a group 30 controls AGA (appropriate gestational...
BACKGROUND & AIMS Lipoprotein(a) has been recognized as an important risk factor for cardiovascular disease. found to be elevated in sera of acromegalic patients, possibly contributing the increased incidence coronary heart disease these patients. In present study we sought determine effects GH hormonal status on lipoprotein(a) and other lipid parameters, including lipoprotein lipase (LPL) activity. DESIGN Cross‐sectional study. PATIENTS Twenty with either active ( n = 12) or controlled...