A5080924717- Neural dynamics and brain function
- Visual perception and processing mechanisms
- Neurobiology and Insect Physiology Research
- Neural and Behavioral Psychology Studies
- EEG and Brain-Computer Interfaces
- Retinal Development and Disorders
- Neuroscience and Neural Engineering
- Memory and Neural Mechanisms
- Functional Brain Connectivity Studies
- Face Recognition and Perception
- Child and Animal Learning Development
- Neuroscience and Neuropharmacology Research
- Tactile and Sensory Interactions
- Advanced Vision and Imaging
- Ultrasound and Hyperthermia Applications
- Neural Networks and Applications
- Color Science and Applications
- Photoacoustic and Ultrasonic Imaging
- Ultrasound and Cavitation Phenomena
- Neuroscience, Education and Cognitive Function
- Primate Behavior and Ecology
- Cognitive Science and Mapping
- Motor Control and Adaptation
- Advanced Scientific Research Methods
- Single-cell and spatial transcriptomics
New York University Press
1993-2022
Cornell University
2022
State Street (United States)
2022
Neurosciences Institute
2015-2021
Stanford University
2012-2021
Howard Hughes Medical Institute
2010-2019
Washington School of Psychiatry
1996
University of Washington
1996
Stony Brook University
1985-1995
California Institute of Technology
1980-1994
Cortical neurons exhibit tremendous variability in the number and temporal distribution of spikes their discharge patterns. Furthermore, this appears to be conserved over large regions cerebral cortex, suggesting that it is neither reduced nor expanded from stage within a processing pathway. To investigate principles underlying such statistical homogeneity, we have analyzed model synaptic integration incorporating highly simplified integrate fire mechanism with decay. We “high-input regime”...
We recorded the activity of single neurons in posterior parietal cortex (area LIP) two rhesus monkeys while they discriminated direction motion random-dot visual stimuli. The task was similar to a discrimination that has been used previous investigations motion-sensitive regions extrastriate cortex. were trained decide whether toward one choice targets appeared on either side stimulus. At end trial, reported their judgment by making an eye movement appropriate target. studied LIP exhibited...
Abstract We have previously documented the exquisite motion sensitivity of neurons in extrastriate area MT by studying relationship between their responses and direction strength visual signals delivered to receptive fields. These results suggested that might provide supporting behavioral choice discrimination tasks. To approach this question from another direction, we now studied discharge choice, independently effects stimulation. found trial-to-trial variability neuronal was correlated...
Psychologists and economists have long appreciated the contribution of reward history expectation to decision-making. Yet we know little about how specific histories choice lead an internal representation "value" possible actions. We approached this problem through integrated application behavioral, computational, physiological techniques. Monkeys were placed in a dynamic foraging environment which they had track changing values alternative choices time. In context, monkeys' behavior...
The primate visual system offers unprecedented opportunities for investigating the neural basis of cognition. Even simplest discrimination task requires processing sensory signals, formation a decision, and orchestration motor response. With our extensive knowledge oculomotor systems as base, it is now possible to investigate simple decisions that link sensation action. Here we describe an initial study responses in lateral intraparietal area (LIP) cerebral cortex while alert monkeys...
1. We investigated cells in the middle temporal visual area (MT) and medial superior (MST) that discharged during smooth pursuit of a dim target an otherwise dark room. For each these we determined whether response originated from stimulation retina by or extraretinal input related to movement itself. distinguished between alternatives removing motion stimulus either blinking off briefly stabilizing on retina. 2. In foveal representation MT (MTf), found usually decreased their rate discharge...
We have previously shown that some neurons in extrastriate area MT are capable of signaling the global motion complex patterns; randomly sampled from V1, on other hand, respond only to individual oriented components. Because a small fraction V1 projects MT, we wished establish processing hierarchy more precisely by studying properties those projecting identified antidromic responses electrical stimulation MT. The project were directionally selective and, like neurons, responded components...
Dynamic random-dot stimuli have been widely used to explore central mechanisms of motion processing. We measured the responses neurons in area MT alert monkey while we varied strength and direction signal such displays. The is controlled by proportion spatiotemporally correlated dots, which term correlation stimulus. For many cells, approximately linearly with stimulus correlation. When they occurred, nonlinearities were equally likely be either positively or negatively accelerated. also...
We studied the simultaneous activity of pairs neurons recorded with a single electrode in visual cortical area MT while monkeys performed direction discrimination task. Previously, we reported strength interneuronal correlation spike count on time scale behavioral epoch (2 sec) and noted its potential impact signal pooling (Zohary et al., 1994). have now examined at longer shorter scales found that pair-wise cross-correlation was predominantly short term (10–100 msec). Narrow, central peaks...
The superior colliculus (SC) is part of a network brain areas that directs saccadic eye movements, overtly shifting both gaze and attention from position to position, in space. Here, we seek direct evidence the SC also contributes control covert spatial attention, process focuses on region space different point gaze. While requiring monkeys keep their fixed, tested whether microstimulation specific location map would enhance visual performance at corresponding space, diagnostic measure...
Mechanisms of direction selectivity and speed were studied in single neurons the middle temporal visual area (MT) behaving macaque monkeys. Visual stimuli presented both smooth stroboscopic motion within a neuron's receptive field as monkey fixated stationary point light. Direction selectivity, spontaneous discharge characteristics MT monkeys similar to those reported previous studies anesthetized Stroboscopic sequences flashes characterized by spatial intervals between each flash. The...