A5031606158- Biochemical Acid Research Studies
- Electrospun Nanofibers in Biomedical Applications
- Bipolar Disorder and Treatment
- Radiopharmaceutical Chemistry and Applications
- Advanced Sensor and Energy Harvesting Materials
- Free Radicals and Antioxidants
- Monoclonal and Polyclonal Antibodies Research
- Electrochemical Analysis and Applications
- Nanoparticles: synthesis and applications
- Biochemical effects in animals
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- HER2/EGFR in Cancer Research
- Neurological Disorders and Treatments
- Climate Change and Health Impacts
- Electrochemical sensors and biosensors
- Synthesis and biological activity
- Vitamin C and Antioxidants Research
- Neuroscience and Neuropharmacology Research
- Human Health and Disease
- Extraction and Separation Processes
- Carbon and Quantum Dots Applications
- Quinazolinone synthesis and applications
- Prostate Cancer Treatment and Research
- Carcinogens and Genotoxicity Assessment
Tomsk National Research Medical Center
2018-2025
National Research Tomsk State University
2016-2025
Tomsk Polytechnic University
2016-2025
Russian Academy of Sciences
2019-2025
Theranostics (New Zealand)
2025
Mental Health Research Institute
2021-2024
Siberian State Medical University
2004-2024
Perm National Research Polytechnic University
2023
Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
2020
Institute for Studies of Society, Economy and Environment
2020
The concept of wearables is rapidly evolving from flexible polymer-based devices to textile electronics. reason for this shift the ability textiles ensure close contact with skin, resulting in comfortable, lightweight, and compact "always you" sensors. We are contributing polymer-textile transition by introducing a novel simple way laser intermixing graphene synthetic fabrics create wearable sensing platforms. Our hybrid materials exhibit high electrical conductivity (87.6 ± 36.2 Ω/sq) due...
Wound healing of the oral mucosa is an urgent problem in modern dental surgical practice. This research article presents and compares findings investigations structural, physicochemical, biological characteristics two types polymeric membranes used for regeneration mucosa. The were prepared from poly(tetrafluoroethylene) (PTFE) a copolymer vinylidene fluoride tetrafluoroethylene (VDF-TeFE) analyzed via scanning electron microscopy, atomic force X-ray diffraction analysis, Fourier transform...
177Lu-labeled small-molecule prostate-specific membrane antigen (PSMA) targeted tracers are therapeutic agents for metastatic castration-resistant prostate cancer. Optimizing molecular design holds the potential to further enhance pharmacokinetic properties of PSMA-targeted while preserving their potent effects. In this study, six novel N-[N-[(S)-1,3-dicarboxypropyl]carbamoyl]-(S)-l-lysine (DCL) urea-based PSMA ligand 2,2′,2″,2‴-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic...
While most of the research in graphene-based materials seeks high electroactive surface area and ion intercalation, here, we show an alternative electrochemical behavior that leverages graphene's potential biosensing. We report a novel approach to fabricate graphene/polymer nanocomposites with near-record conductivity levels 45 Ω sq–1 enhanced biocompatibility. This is realized by laser processing graphene oxide sandwich structure thin (100 μm) polyethylene terephthalate film on textile...
The human body is constantly under attack from free radicals that occur as part of normal cell metabolism, and by exposure to environmental factors such UV light, cigarette smoke, pollutants gamma radiation. resulting "Reactive Oxygen Species" (ROS) circulate freely in the with access all organs tissues, which can have serious repercussions throughout body. possesses a number mechanisms both control production ROS cope order limit or repair damage tissues. Overproduction insufficient defense...
There is currently a demand for anti-adhesive materials that are capable of preventing the formation intra-abdominal adhesions. In this study, electrospun poly(lactide-co-glycolide) scaffolds were dip-coated in aqueous solutions polyvinyl alcohol with concentrations 3 wt.%, 6 wt.% and 9 to obtain nontoxic biomedical material. The viscosities applied 7.7 mPa∙s, 38.2 mPa∙s 180.8 respectively, increased exponentially. It shown increasing viscosity solution from increases thickness layer (3.32 ±...
Bone injuries remain a significant challenge, driving the development of new materials and technologies to enhance healing. This study presents novel approach for incorporating graphene into calcium phosphate (CaP) coatings on titanium alloy (Ti) substrates, with aim creating generation bone implant electronics. The stability composite coating under physiological conditions, long-term electrical mechanical durability, biocompatibility were systematically investigated. We integrated CaP...
Growing interest in cancer radiotherapy has led to the application of nanoparticles as radiosensitizers. Here, we, for first time, present results radiosensitizing properties silver (AgNPs) (possessing low toxicity towards human body) against cells under neutron irradiation. Five standard cultures (including glioblastoma, known its resistance conventional photon radiation) were used evaluate AgNPs suing MTT test, flow cytometry, and optical fluorescence microscopy. Neutron irradiation was...
Heterodimeric approaches have emerged as a promising method for simultaneously targeting multiple receptors on tumor cells using single molecule. Simultaneous of the prostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptor (GRPr) holds potential to improve accuracy prostate cancer diagnosis. The aim this study was develop convenient simple modular strategy creation heterobivalent (HBV) conjugates PSMA/GRPr receptors. For purpose, we developed compared six alternative...
Antibiotic resistance of bacteria stimulates the development new treatment approaches. Piezoelectric-catalysis has attracted much attention due to possibility effectively provide antibacterial effect via generation reactive oxygen species. However, influence surface charge or potential a piezopolymer on not been sufficiently studied so far. This study reports fabrication and characterization thin films piezoelectric polyhydroxybutyrate, polyvinylidene fluoride, fluoride trifluoroethylene as...
A new simple electrochemical immunosensor approach for the determination of antibodies to tick-borne encephalitis virus (TBEV) in immunological products was developed and tested. The assay is performed by detecting silver reduction signal bioconjugates with (Ab@AgNP). Here, read cathodic linear sweep voltammetry (CLSV) through detection chloride on a gold–carbon composite electrode (GCCE). Covalent immobilization antigen surface after thiolation glutarization GCCE. Specific attention has...
Structural electronics, as well flexible and wearable devices are applications that possible by merging polymers with metal nanoparticles. However, using conventional technologies, it is challenging to fabricate plasmonic structures remain flexible. We developed three-dimensional (3D) nanostructures/polymer sensors via single-step laser processing further functionalization 4-nitrobenzenethiol (4-NBT) a molecular probe. These allow ultrasensitive detection surface-enhanced Raman spectroscopy...
Silver nanoparticles (AgNPs) have a wide range of bioactivity, which is highly dependent on particle size, shape, stabilizer, and production method. Here, we present the results studies AgNPs cytotoxic properties obtained by irradiation treatment silver nitrate solution various stabilizers accelerating electron beam in liquid medium.The morphological characteristics were transmission microscopy, UV-vis spectroscopy, dynamic light scattering measurements. MTT test, alamar blue flow cytometry,...
The growing resistance of bacteria to antibiotics is one the main public health problems nowadays. influence silver nanoparticle (AgNP) pretreatment 220 cows with mastitis on susceptibility Staphylococcus epidermidis 31 was studied. obtained results were compared previous for Escherichia coli, Streptococcus dysgalactiae, and aureus. For all four bacteria, an increase in (9.5–21.2%) after cow treatment AgNPs revealed, while first-line antibiotic drug as expected, decreased (11.3–27.3%). These...
A blood test can provide important information about the functional state of antioxidant system. Malfunction this system increases concentration free radicals and cause oxidative stress. difficulty in assessing stress is lack a universal method for determining activity (AOA) components, because their different nature.The objects investigation were sera 30 male patients with diagnosis alcohol dependence syndrome healthy donors. Comparative total (TAA) human serum was carried out by...
For surface-enhanced Raman spectroscopy (SERS) sensing of small molecules in the presence living cells, biofouling and blocking plasmonic centers are key challenges. Here, we have developed a mesoporous Au (AuM) film coated with Ag nanoparticles (NPs) as sensor (AuM@Ag) to analyze aromatic thiols, which is an example molecule, cell strain (e.g., MDA-MB-231) model system. The resulting AuM@Ag provides 0.1 nM sensitivity high reproducibility for thiols sensing. Simultaneously, filters large...
Antioxidant potentials in sprouts vs. seeds of Vigna radiata and Macrotyloma uniflorumC. K., Abdul Rehman, Prabhakar B. T., Vijay Avin R., Aditya Rao S. J.
Radionuclide molecular imaging could provide an accurate assessment of the expression targets in disseminated cancers enabling stratification patients for specific therapies. B7-H3 (CD276) is a transmembrane protein belonging to B7 superfamily. This overexpressed different types human malignancies and such upregulation generally associated with poor clinical prognosis. In this study, targeting properties Affibody-based probe, AC12, containing -GGGC amino acid sequence as chelator (designated...
A critical parameter during the development of protein therapeutics is to endow them with suitable pharmacokinetic and pharmacodynamic properties. Small drugs are quickly eliminated by kidney filtration, in vivo half-life extension therefore often desired. Here, different technologies were studied where PAS polypeptides (PAS300, PAS600), XTEN (XTEN288, XTEN576), an albumin binding domain (ABD) compared for anti-human epidermal growth factor receptor 2 (HER2) affibody-drug conjugate. The...
Phenothiazine and its derivatives have a number of properties that contribute to their wider practical use in the production biologically active substances, drugs, dyes, etc. Therefore, synthesis study new compounds is great relevance. The aim this work was investigate antioxidant activity phenothiazine derivatives. patterns electroreduction oxygen radicals presence aqueous ethanol media were studied by voltammetry. influence various factors on considered methods experiment planning. optimal...
The c-Jun N-terminal kinases (JNKs) regulate many physiological processes, including inflammatory responses, morphogenesis, cell proliferation, differentiation, survival, and death. Therefore, JNKs represent attractive targets for therapeutic intervention. In an effort to develop improved JNK inhibitors, we synthesized the lithium salt of 11H-indeno[1,2-b]quinoxaline-11-one oxime (IQ-1L) evaluated its affinity biological activity in vitro vivo. According density functional theory (DFT)...