A5006195285- Neurotransmitter Receptor Influence on Behavior
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Neural and Behavioral Psychology Studies
- Stress Responses and Cortisol
- Neural Networks and Applications
- Functional Brain Connectivity Studies
- Neuroscience and Neural Engineering
- Cannabis and Cannabinoid Research
- Mental Health Research Topics
- Neuroendocrine regulation and behavior
- Olfactory and Sensory Function Studies
- Decision-Making and Behavioral Economics
- Zebrafish Biomedical Research Applications
- stochastic dynamics and bifurcation
- Obsessive-Compulsive Spectrum Disorders
- Ion channel regulation and function
- Pancreatic function and diabetes
- Substance Abuse Treatment and Outcomes
- Computational Drug Discovery Methods
- Adipose Tissue and Metabolism
- Biomedical Text Mining and Ontologies
- Digital Mental Health Interventions
Indiana University – Purdue University Indianapolis
2016-2025
Indiana University School of Medicine
2015-2025
Indiana University
2015-2025
University School
2015-2025
Neuroscience Institute
2024
University of Indianapolis
2013-2024
Neurosciences Institute
2024
Wyss Center for Bio and Neuroengineering
2023
Computational Sciences (United States)
2017
University of British Columbia
2008-2014
The relative contributions of glutamate and dopamine within the nucleus accumbens to cocaine-induced reinstatement drug-seeking behavior were assessed. When extinguished cocaine self-administration was reinstated by a cocaine-priming injection, extracellular levels both elevated in accumbens. However, when yoked or saline control subjects administered prime, only elevated. Thus, increased animals lever pressing, whereas regardless behavior. increase not accounted for simply act pressing...
The role of limbic, cortical, and striatal circuitry in a footshock reinstatement model relapse to cocaine seeking was evaluated. Transient inhibition the central extended amygdala [CEA; including nucleus (CN), ventral bed stria terminalis (BNSTv), accumbens shell (NAshell)], tegmental area (VTA), motor [including dorsal prefrontal cortex (PFCd), core (NAcore), pallidum (VP)] blocked ability stress reinstate lever pressing previously associated with delivery. However, basolateral amygdala,...
The performance of complex networks, like the brain, depends on how effectively their elements communicate. Despite importance communication, it is virtually unknown information transferred in local cortical consisting hundreds closely spaced neurons. To address this, important to record simultaneously from neurons at a spacing that matches typical axonal connection distances, and temporal resolution synaptic delays. We used 512-electrode array (60 μm spacing) spontaneous activity 20 kHz up...
In vivo extracellular recording studies have traditionally shown that dopamine (DA) transiently inhibits prefrontal cortex (PFC) neurons, yet recent biophysical measurements in vitro indicate DA enhances the evoked excitability of PFC neurons for prolonged periods. Moreover, although apparently encode stimulus salience by transient alterations firing, temporal properties signal associated with various behaviors is often extraordinarily prolonged. The present study used electrophysiological...
Abstract Frontloading is an alcohol drinking pattern where intake skewed toward the onset of access. The goal current study was to identify brain regions involved in frontloading. Whole imaging performed 63 C57Bl/6J (32 female and 31 male) mice that underwent 8 days binge using drinking-in-the-dark (DID) model. On 1-7, three hours into dark cycle, received 20% (v/v) or water for two hours. Intake measured 1-minute bins volumetric sippers, which facilitated analyses patterns. day were...
Successful decision making requires an ability to monitor contexts, actions, and outcomes. The anterior cingulate cortex (ACC) is thought be critical for these functions, monitoring guiding decisions especially in challenging situations involving conflict errors. A number of different single-unit correlates have been observed the ACC that reflect diverse cognitive components involved. Yet how neurons function as integrated network poorly understood. Here we show, using advanced population...
Cognitive functions supported by neurons in the prefrontal cortex (PFC) are disrupted acute and chronic exposure to alcohol, yet little is known about mechanisms that underlie these effects. In present study, vivo vitro electrophysiology was used determine effects of ethanol on neuronal firing network patterns persistent activity PFC neurons. vivo, (0.375-3.5 g/kg) dose-dependently reduced spike measured with multielectrode extracellular recording anesthetized rat. an coculture system...
A common theoretical view is that attractor-like properties of neuronal dynamics underlie cognitive processing. However, although often proposed theoretically, direct experimental support for the convergence neural activity to stable population patterns as a signature attracting states has been sparse so far, especially in higher cortical areas. Combining state space reconstruction theorems and statistical learning techniques, we were able resolve details anterior cingulate cortex (ACC)...
Abstract A key feature of compulsive alcohol drinking is continuing to drink despite negative consequences. To examine the changes in neural activity that underlie this behavior, was assessed a validated rodent model heritable risk for excessive (alcohol preferring (P) rats). Neural measured dorsal medial prefrontal cortex (dmPFC—a brain region involved maladaptive decision-making) and via change point analyses novel principal component analyses. population representations specific...
Highlights•dlPFC intrinsically maintains recurrent activity in the absence of extrinsic inputs•Identical inputs are routed through labile, stochastically assembled ensembles•Stable population-level representations arise from unstable ensembles•Microcircuit excitability covaried with individual cognitive flexibilitySummaryHuman and non-human primate studies clearly implicate dorsolateral prefrontal cortex (dlPFC) as critical for advanced functions.1,2 It is thought that intracortical synaptic...
Fluorescent sensors have revolutionized the measurement of molecules in brain, and dLight dopamine sensor has been used extensively to examine reward- cue-evoked release, but only recently field turned its attention spontaneous release events. Analysis events typically requires evaluation hundreds over minutes hours, most common method analysis, z-scoring, was not designed for this purpose. Here, we compare accuracy reliability three different analysis methods identify pharmacologically...
While Dale's principle of “one neuron, one neurotransmitter” has undergone revisions to incorporate evidence the corelease atypical neurotransmitters such as neuropeptides, classical only recently been realized. Surprisingly, numerous studies now indicate that in mammalian central nervous system is not an obscure and rare phenomenon but widespread involves most systems. However, suggestion glutamate can be coreleased with dopamine (DA) remained controversial. Furthermore, glutamate‐DA...
Modulation of neural activity by monoamine neurotransmitters is thought to play an essential role in shaping computational neurodynamics the neocortex, especially prefrontal regions. Computational theories propose that monoamines may exert bidirectional (concentration-dependent) effects on cognition altering cortical attractor dynamics according inverted U-shaped function. To date, this hypothesis has not been addressed directly, part because absence appropriate statistical methods required...
Abstract The ability to flexibly switch between goal-directed actions and habits is critical for adaptive behavior. infralimbic prefrontal cortex (IfL-C) has been consistently identified as a crucial structure the regulation of response strategies. To investigate role IfL-C, present study employed two validated reinforcement schedules that either promote or in mice. results reveal information about action-outcome relationships differentially encoded IfL-C during evidenced by encoding...
Connections between the hippocampus (HC) and medial prefrontal cortex (mPFC) are critical for working memory; however, precise contribution of this pathway is a matter debate. One suggestion that it may stabilize retrospective memories recently encountered task-relevant information. Alternatively, be involved in encoding prospective memories, or internal representation future goals. To explore these possibilities, simultaneous extracellular recordings were made from mPFC HC rats performing...
Much remains unknown about the etiology of compulsion-like alcohol drinking, where consumption persists despite adverse consequences. The role anterior insula (AIC) in emotion, motivation, and interoception makes this brain region a likely candidate to drive challenge-resistant behavior, including compulsive drinking. Indeed, subcortical projections from AIC promote intake rats, are recruited heavy-drinking humans during compulsion for alcohol, highlighting importance need more information...