A5032073974- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Pesticide Exposure and Toxicity
- Neural dynamics and brain function
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Substance Abuse Treatment and Outcomes
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neural and Behavioral Psychology Studies
- Zebrafish Biomedical Research Applications
- Animal Ecology and Behavior Studies
- Functional Brain Connectivity Studies
- Adipose Tissue and Metabolism
- Mental Health Research Topics
- Insect and Pesticide Research
- Immunotoxicology and immune responses
- Biochemical effects in animals
- Olfactory and Sensory Function Studies
- Environmental Toxicology and Ecotoxicology
- Infectious Encephalopathies and Encephalitis
- Behavioral Health and Interventions
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
Indiana University – Purdue University Indianapolis
2020-2024
University of Indianapolis
2023
Purdue University West Lafayette
2023
United States Army
2018-2020
CECOM Software Engineering Center
2018
Abstract Frontloading is an alcohol drinking pattern where intake skewed toward the onset of access. The goal current study was to identify brain regions involved in frontloading. Whole imaging performed 63 C57Bl/6J (32 female and 31 male) mice that underwent 8 days binge using drinking-in-the-dark (DID) model. On 1-7, three hours into dark cycle, received 20% (v/v) or water for two hours. Intake measured 1-minute bins volumetric sippers, which facilitated analyses patterns. day were...
Organophosphorus nerve agents (OPNAs) irreversibly block acetylcholinesterase activity, resulting in accumulation of excess acetylcholine at neural synapses, which can lead to a state prolonged seizures known as status epilepticus (SE). Benzodiazepines, the current standard care for SE, become less effective latency treatment increases. In mass civilian OPNA exposure, concurrent trauma and limited resources would likely cause delay first response time. To address this issue, we have...
Abstract Frontloading is an alcohol drinking pattern where intake skewed towards the onset of access. This study aimed to identify brain regions involved in frontloading. Whole imaging was performed 63 C57Bl/6J (32 female, 31 male) mice that underwent 8 days binge using drinking‐in‐the‐dark (DID). On Days 1–7 received 20% (v/v) or water for 2 h. Intake measured 1‐min bins volumetric sippers. Day were perfused 80 min into DID session and brains extracted. Brains processed stain Fos protein...
Beyond yielding high blood ethanol (EtOH) concentrations (BECs), binge-drinking models allow examination of drinking patterns which may be associated with EtOH's rewarding effects, including front-loading and consummatory successive negative contrast (cSNC), a decrease in intake when only water is available to subjects expecting EtOH. The goals the current study were broaden our understanding these reward-related behaviors during binge EtOH access alcohol-preferring (HAP) replicate lines...
Summary Objectives Children and adults are likely to be among the casualties in a civilian nerve agent exposure. This study evaluated efficacy of valnoctamide (racemic‐VCD), sec ‐butylpropylacetamide (racemic‐SPD), phenobarbital for stopping seizures both immature adult rats. Methods Female male postnatal day ( PND ) 21, 28, 70 (adult) rats, previously implanted with electroencephalography (EEG) electrodes were exposed seizure‐inducing doses agents sarin or VX EEG was recorded continuously....
A key facet of alcohol use disorder is continuing to drink despite negative consequences (so called "aversion-resistant drinking"). In this study, we sought assess the degree which head-fixed mice exhibit aversion-resistant drinking and leverage behavioral analysis techniques available in head-fixture relate non-consummatory behaviors drinking. We assessed female male C57BL/6J mice. adulterated 20% (v/v) with varying concentrations bitter tastant quinine measure would continue aversive...
Decreased functional connectivity between the striatum and frontal cortex is observed in individuals with alcohol use disorder (AUD), predicts probability of relapse abstinent AUD. To further our understanding how repeated (ethanol; EtOH) consumption impacts corticostriatal circuit, extracellular electrophysiological recordings (local field potentials; LFPs) were gathered from nucleus accumbens (NAc) prefrontal (PFC) C57BL/6J mice voluntarily consuming EtOH or water using a...