A5027019670- Epilepsy research and treatment
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Enzyme function and inhibition
- Pharmacological Effects and Toxicity Studies
- Celiac Disease Research and Management
- Lymphadenopathy Diagnosis and Analysis
- Hematological disorders and diagnostics
- Antibiotics Pharmacokinetics and Efficacy
- Iron Metabolism and Disorders
- Pesticide Exposure and Toxicity
- Ion channel regulation and function
- Immunodeficiency and Autoimmune Disorders
- Drug Transport and Resistance Mechanisms
Hebrew University of Jerusalem
2016-2021
Abderrahmane Mami Hospital
2007
Summary Objectives Children and adults are likely to be among the casualties in a civilian nerve agent exposure. This study evaluated efficacy of valnoctamide (racemic‐VCD), sec ‐butylpropylacetamide (racemic‐SPD), phenobarbital for stopping seizures both immature adult rats. Methods Female male postnatal day ( PND ) 21, 28, 70 (adult) rats, previously implanted with electroencephalography (EEG) electrodes were exposed seizure‐inducing doses agents sarin or VX EEG was recorded continuously....
3-Methylpentyl(4-sulphamoylphenyl)carbamate (MSPC) came as the most potent compound out of a new series carbamates composed phenyl-ethanol or branched aliphatic alcohols, and 4-benzenesulphonamide-carbamic acid. In this study, anticonvulsant activity pharmacokinetics (PKs) MSPC-two individual enantiomers were comparatively analysed in rats well their carbonic anhydrase (CA) inhibition. The MSPC was evaluated at rat-maximal electroshock (MES) test, CA inhibition evaluated. (R)-MSPC had 29%...
sec-Butylpropylacetamide (SPD) is the amide derivative of valproic acid (VPA). SPD possess a wide-spectrum anticonvulsant profile better than that VPA and blocks status epilepticus (SE) induced by pilocarpine organophosphates. The activity on SE benzodiazepines (BZDs) in terms ability to block when given 20-60 min after beginning seizure. However, intraperitoneal (i.p.) administration rats cannot be extrapolated humans. Consequently, current study comparative pharmacokinetic...
We recently reported a new class of carbamate derivatives as anticonvulsants. Among these, 3-methylpentyl(4-sulfamoylphenyl)carbamate (MSPC) stood out the most potent compound with ED50 values 13 mg/kg (i.p.) and 28 (p.o.) in rat maximal electroshock test (MES). 3-Methylpropyl(4-sulfamoylphenyl)carbamate (MBPC), characterized here, is an MSPC analogous two less aliphatic carbon atoms its structure. As both MBPC are chiral compounds, we studied carbonic anhydrase inhibitory anticonvulsant...
Abstract Objectives To advance the development of (2S,3S)‐ sec ‐butylpropylacetamide (SPD) as a new treatment for acute repetitive seizures (ARS), by studying its pharmacokinetics (PK) in pigs and PK‐pharmacodynamic (PK‐PD) correlation rats. Methods Two (2S,3S)‐SPD intramuscular formulations (F A F B ) were administered to rats blood samples withdrawn at different times after dosing. Major PK parameters estimated both species. PD analysis was conducted utilizing maximal‐electroshock seizure...