A5101686330- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Cellular Mechanics and Interactions
- Virus-based gene therapy research
- Lung Cancer Treatments and Mutations
- Virology and Viral Diseases
- Drug Transport and Resistance Mechanisms
- Stroke Rehabilitation and Recovery
- COVID-19 and Mental Health
- Physical Activity and Health
- Plant Virus Research Studies
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related Molecular Pathways
- Scoliosis diagnosis and treatment
- Cardiovascular and exercise physiology
- Mindfulness and Compassion Interventions
- Pancreatic and Hepatic Oncology Research
- COVID-19 Clinical Research Studies
- Cell Adhesion Molecules Research
- 3D Printing in Biomedical Research
- SARS-CoV-2 and COVID-19 Research
- Microtubule and mitosis dynamics
- Lung Cancer Research Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Erythrocyte Function and Pathophysiology
University of Kalyani
2022-2023
RayBiotech (United States)
2022
Memorial Sloan Kettering Cancer Center
2016-2020
University of South Florida
2017
Moffitt Cancer Center
2014
University of Pittsburgh
2008
Cleveland Clinic
1993-1997
University of Miami
1997
Phosphorylation by casein kinase II at three specific residues (S-60, T-62, and S-64) within the acidic domain I of P protein Indiana serotype vesicular stomatitis virus has been shown to be critical for in vitro transcription activity viral RNA polymerase (P-L) complex. To examine role phosphorylation as well replication vivo, we used a panel mutant proteins which phosphate acceptor sites were substituted with alanines or other amino acids. Analyses alanine-substituted ability support...
Specific interaction between the nucleocapsid protein (N) and phosphoprotein (P) of vesicular stomatitis virus (VSV), an important step in life-cycle virus, was studied by using a two-hybrid system. Plasmids encoding P fused with yeast GAL4 DNA-binding domain (pGALP) N herpes simplex VP16 transactivating region (pVPN) were transfected into CHO cells along reporter plasmid chloramphenicol acetyltransferase (CAT). The ability to associate vivo measured activation CAT gene region. Transfection...
Background. Yoga, an ancient practice rooted in Indian culture, has gained global recognition for its physical and mental health benefits. Among practices, Surya Namaskar (SN) stands out as a holistic yogic Sun Salutation exercise combining postures, breathing, mindfulness, offering vitality, calmness, practical solution to the challenges posed by modern sedentary lifestyles. Objectives. The objective of present systematic review was analyze effect SN on overall wellness healthy adults....
ATP-binding cassette (ABC) drug transporters consuming ATPs for efflux is a common mechanism by which clinical cancers develop multidrug resistance (MDR). We hypothesized that MDR phenotypes could be suppressed administration of "ersatzdroges," nonchemotherapy drugs are, nevertheless, ABC substrates. reasoned that, through prolonged activation the pumps, ersatzdroges will force cells to divert limited resources from proliferation and invasion thus delaying disease progression. evaluated...
Abstract Profilin‐1 (Pfn1), a ubiquitously expressed actin‐binding protein, has been regarded as tumor‐suppressor molecule for breast cancer. Since AKT signaling impacts cell survival and proliferation, in this study we investigated whether activation cancer cells is sensitive to perturbation of Pfn1 expression. We found that even moderate overexpression leads significant reduction phosphorylation MDA‐MB‐231 cells. further demonstrated associated with the level phosphoinositide regulator...
Background/Aim: One of the major hurdles in treatment breast cancers is inability anti-cancer drugs to eliminate cancer stem cells (BCSCs) population, which leads disease relapse. The dearth that target BCSCs can be attributed absence vitro screening models not only recapitulate tumor microenvironment consisting but also preserve 3-dimensional (3D) architecture vivo tumors. Materials and Methods: In our present study, we have developed a 3D cell culture system shows: (i) enrichment BCSCs,...
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has become a worldwide pandemic, and there pressing need for the rapid development of novel therapeutic strategies. SARS-CoV-2 viral entry mediated interaction between receptor binding domain (RBD) Spike protein host cellular receptor, human angiotensin converting enzyme (ACE2). The lack high throughput screening (HTS) platform candidate drug means that no targeted...
Background: The advancement of technology and medical science has prolonged the longevity humans, compelling each individual to deal with old age. New health issues are cropping up, especially since lifestyle become sedentary. Regular physical exercises only option for healthy aging. Purpose: study observed effect 10 weeks planned community-based multicomponent exercise program (CBMCEP) on selected physiological variables elderly women in Indian sub-urban area. Methodology: A...
Background: Technological inventions are promoting a sedentary lifestyle. With aging limited physical activities result in postural instability, falls, and mobility reduction, for which the two fitness components - balance flexibility play indispensable roles. Among many exercise protocols, Pilates is one of most beneficial regimens developing core muscle strength, balance, flexibility, aerobic capacity middle-aged women. Purpose: The purpose current pilot study was to examine influence...