A5070920801- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Computational Drug Discovery Methods
- Tuberculosis Research and Epidemiology
- Vitamin C and Antioxidants Research
- Vibrio bacteria research studies
- Nephrotoxicity and Medicinal Plants
- Enterobacteriaceae and Cronobacter Research
- Resilience and Mental Health
- COVID-19 and Mental Health
- Pneumonia and Respiratory Infections
- Nanoparticles: synthesis and applications
- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- Bacterial Identification and Susceptibility Testing
- Soil and Land Suitability Analysis
- Berberine and alkaloids research
- Plant Pathogens and Fungal Diseases
- Cholinesterase and Neurodegenerative Diseases
- Trace Elements in Health
- Antimicrobial Resistance in Staphylococcus
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Use and Resistance
- Optimism, Hope, and Well-being
- Enzyme function and inhibition
Isfahan University of Medical Sciences
2017-2023
University of Isfahan
2021
Shahrekord University of Medical Sciences
2015-2017
Ahvaz Jundishapur University of Medical Sciences
2015-2016
The emerging new Coronaviridae member, nCoV 19, outbreak announced a pandemic by WHO with an increased morbidity and mortality rate worldwide. 19 known as the third highly pathogen coronavirus in human population after severe acute respiratory syndrome (SARS-CoV) Middle East (MERS-CoV), 19. renin-angiotensin (RAS) signaling pathway, oxidative stress cell death, cytokines storm endothelial dysfunction are four major pathways involved pathogenesis of Acute distress (ARDS) generally develops...
Abstract New Delhi metallo-β-lactamase variants and different types of metallo-β-lactamases have attracted enormous consideration for hydrolyzing almost all β-lactam antibiotics, which leads to multi drug resistance bacteria. Metallo-β-lactamases genes disseminated in hospitals parts the world became a public health concern. There is no inhibitor metallo-β-lactamase-1 other classes, so drugs an urgent need. In this study, multi-steps virtual screening was done over NPASS database with 35,032...
Abstract With the progressive and ever-increasing antibacterial resistance pathway, need for novel antibiotic design becomes critical. Sulfonamides are one of more effective antibiotics against bacteria. In this work, several sulfonamide hybrids including coumarin isoxazole group were synthesized in five steps starting from coumarin-3-carboxylic acid 3-amino-5-methyl assayed activity. The samples obtained good to high yield characterized by FT-IR, 13 C-NMR, 1 H-NMR, CHN melting point...
Acinetobacter spp. is a diverse group of Gram-negative bacteria which are ubiquitous in soil and water, an important cause nosocomial infections. The purpose this study was to identify collection clinical isolates accurately investigate their antibiotic susceptibility patterns.A total 197 non-duplicate identified using conventional biochemical tests. molecular technique PCR-RFLP sequence analysis rpoB 16S rRNA genes applied for species identification. Antimicrobial test performed with disk...
Background: The SARS-CoV-2 virus is a new highly contagious Coronavirus with positive-sense RNA encoding 16 non-structural proteins (nsps16, nsp15, nsp3). In this study, the coronavirus pathogenicity and losartan functional ligand for inhibiting TRPM2 macrodomain have been molecularly evaluated.Material method: structures of binding ADP ribose in CoVs human Transient Receptor Potential Cation Channel Subfamily M Member 2 (TRPM2) protein were downloaded from data bank. Then, virtual screening...
Acinetobacter baumannii has become one of the most serious causative agents nosocomial infections due to its significant ability survive on hospital surfaces. It is mainly an emerging opportunistic pathogen infecting patients in intensive care units. This study was aimed identify clinical isolates A. and investigate their heterogeneity using polymerase chain reaction (PCR)-based typing methods.A total 197 nonduplicate recovered from a wide range samples were subjected conventional cultural...
Resistance-nodulation-cell devision (RND) efflux pump variants have attracted a great deal of attention for many antibiotic classes, which leads to multidrug-resistant bacteria. The present study aimed discover the interaction between RND pumps and antibiotics, find conserved hot spot residues, use this information target most frequent pumps. Protein sequence 3D conformational alignments, pharmacophore modeling, molecular docking, dynamics simulation were used in first level discovering...
Pseudomonas aeruginosa has different antibiotic resistance pathways, such as broad-spectrum lactamases and metallo-β-lactamases (MBL), penicillin-binding protein (PBP) alteration, active efflux pumps. Polymerase chain reaction (PCR) sequencing methods were applied for double-locus sequence typing (DLST) New Delhi metallo-β-lactamase (NDM) typing. We deduced the evolutionary pathways DLST NDM genes of P. using phylogenetic network. Among analyzed isolates, 62.50% isolates phenotypically...
Coronavirus and its stress can have a significant impact on an individual’s psychological physical well-being. Studies show that children adolescents are among the most vulnerable groups as they lack adaptive coping strategies. The purpose of current study was to investigate mediating effect optimism pessimism association between coronavirus youth internalizing problems Iranian adolescents. sample this included 408 students (42.4% female) recruited through cluster sampling. Participants were...
Abstract New Delhi metallo-β-lactamase variants and different types of metallo-β-lactamases have attracted enormous consideration for hydrolyzing almost all β-lactam antibiotics, which leads to multi drug resistance bacteria. Metallo-β-lactamases genes disseminated in hospitals parts the world became a public health concern. There is no inhibitor new metallo-β-lactamase-1 other classes, so drugs an urgent need. In this study, multi-steps virtual screening was done over NPASS database with...