A5103190030- Asymmetric Hydrogenation and Catalysis
- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Carbon dioxide utilization in catalysis
- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
- Infrastructure Maintenance and Monitoring
- Organoboron and organosilicon chemistry
- Chemical Reactions and Isotopes
- Nanomaterials for catalytic reactions
- Sulfur-Based Synthesis Techniques
- Asphalt Pavement Performance Evaluation
- Organometallic Complex Synthesis and Catalysis
- CO2 Reduction Techniques and Catalysts
- Chemical Synthesis and Reactions
- Fluorine in Organic Chemistry
- Innovative concrete reinforcement materials
- Metal-Organic Frameworks: Synthesis and Applications
Indian Institute of Technology Roorkee
2021-2025
This article highlights the recent advances and significance of β-alkylation reactions towards synthesis higher order alcohols.
This article highlighted the recent demand for sustainable and resource efficient drug synthesis using electrochemical strategies.
Herein, we have reported the application of C1 and C2 alcohols for C‐C coupling with ketones enabled by nickel. De‐hydrogenation ethanol took place under relatively milder conditions (100 oC) resulted functionalized 1,5‐diketones acetophenone derivatives in one pot operation. Further, multi‐component strategy using ketones, methanol combination various nitrogen‐based nucleophiles α‐aminomethylation nickel‐catalysis. For a synthetic application, series tetra‐substituted pyridines been...
A unified electrochemical decarboxylative strategy for the site‐selective construction of carbon‐heteroatom bonds is disclosed herein. The metal‐ and catalyst‐free decarboxylation provides access to functionalization C‐ N‐terminus from simple amino acid feedstock. wide variety primary, secondary tertiary acids or alcohols were well tolerated. Late stage using α‐D‐galactopyranose, di‐peptide, steroids derivatives bio‐active drug molecules established robustness synthesis potential our approach.
Herein, we have demonstrated a simple nickel-catalyzed C-3-selective alkylation of 2-oxindoles using wide variety secondary alkyl alcohols. As special highlight, functionalization the cholesterol derivative was reported. Control experiments, initial mechanistic studies, and deuterium-labeling experiments were performed for process.
Abstract Herein, a simple and efficient nickel‐catalyzed C‐3‐selective alkylation of 2‐oxindoles using primary alkyl allylic alcohols have been demonstrated. The catalytic protocol enables transformations in the presence free hydroxyl group, amine, cycloalkanes, olefins, lactam including more challenging C2‐C4 alcohols, citronellol oleic acid derived alcohol up to 96 % yield. Initial mechanistic studies deuterium labelling experiments were performed. Synthetic modulations enabled new routes...
Herein, we have demonstrated the design and synthesis of a novel Ni-immobilized MOF as heterogeneous catalyst for dehydrogenation N-heterocycles. A series five six-membered N-heteroarenes bearing one or more heteroatoms were synthesized in up to 98 % yield (>33 examples). Late stage functionalization β-glucuronides inhibitor, antimalarial drug quinine, nonsteroidal anti-inflammatory (NSAID) indomethacin obtained under milder reactions conditions. mechanistic studies revealed detection H
Abstract An efficient and adequate system of transportation is inevitable for the development any country. A high traffic intensity in terms overloaded commercial vehicle, introduction new axle configuration, significant variations daily seasonal temperature pavement are factors contributing to early distress symptoms like ravelling, rutting, cracking, bleeding, shoving pot holing bituminous surfacing, which demand a proper strengthening pavements. The with conventional mixes revealed need...