A5039775425- Amyloidosis: Diagnosis, Treatment, Outcomes
- Parathyroid Disorders and Treatments
- Cardiovascular Function and Risk Factors
- Medical Imaging and Pathology Studies
- Cardiomyopathy and Myosin Studies
- Heart Rate Variability and Autonomic Control
- Sarcoidosis and Beryllium Toxicity Research
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Neuroendocrine Tumor Research Advances
- Cardiac tumors and thrombi
- Cardiac Imaging and Diagnostics
- Cardiovascular Syncope and Autonomic Disorders
- Obstructive Sleep Apnea Research
- Cardiac Arrest and Resuscitation
- Heart Failure Treatment and Management
- RNA regulation and disease
- Eosinophilic Disorders and Syndromes
- Mechanical Circulatory Support Devices
- MicroRNA in disease regulation
- RNA Research and Splicing
- Pulmonary Hypertension Research and Treatments
- Congenital heart defects research
- Moyamoya disease diagnosis and treatment
- Cardiovascular Disease and Adiposity
Centre Hospitalier Universitaire de Martinique
2015-2025
Mycologie et Sécurité des Aliments
2022
Inserm
2014-2016
Sorbonne Université
2016
Hôpital Lariboisière
2015-2016
Délégation Paris 7
2016
Université Paris Cité
2016
Background/Objectives: Cardiac amyloidosis (CA) is associated with amyloid infiltration of the extra-cardiac tissue, which may occur in early stages disease. This study evaluates diagnostic utility thoracic fat pad biopsy obtained during a pacemaker or ICD implantation as an alternative to standard criteria for systemic amyloidosis. Methods: exploratory, retrospective included 27 patients suspected diagnosed CA who underwent defibrillator therapy. Results: Of these, 16 were confirmed have...
Abstract Background We present a case series detailing family with familial cardiac laminopathy, including the female index patient, her father, brother, and daughter, all diagnosed atrial arrhythmias, i.e. fibrillation (AF), flutter, premature contractions. Case summary The patient is known for frequent contractions since age of 35 years persistent AF 46 years. Rhythm control symptomatic was achieved after two ablations. brother asymptomatic 26 He has opted rate oral anticoagulation. Their...
Hypertension, which is a risk factor of heart failure, provokes adaptive changes at the vasculature and cardiac levels. Notch3 signaling plays an important role in resistance arteries by controlling maturation vascular smooth muscle cells. deletion protective pulmonary hypertension while deleterious arterial hypertension. Although this latter phenotype was attributed to renal alterations, underlying mechanisms remained unknown. To investigate adaptation hypertension, we used mice with either...
Transthyretin cardiac amyloidosis (ATTR-CA) is an increasingly recognized disease that often results in heart failure and death. Traditionally, biological staging systems are used to stratify severity. Reduced aerobic capacity has recently been described as useful identifying higher risk of cardiovascular events Assessment lung volume via simple spirometry might also hold prognostic relevance. We aimed assess the combined value spirometry, cardiopulmonary exercise testing (CPET) biomarker...
Abstract Aims Catheter ablations of complex cardiac arrhythmias are currently guided by electro-anatomic mapping (EAM) systems. The aim this study was to compare two different approaches: remotely supported nurse-led EAM with standard onsite engineer support. Methods and results In retrospective observational study, 166 patients non-complex procedures were included. A total 82 benefited from (mean age: 62 ± 16 years), while the approach for 84 support 56 19 years). Procedural...
Background: Impaired aerobic capacity in cardiac amyloidosis patients may be related to limited inotropic myocardial reserve and heart rate (HR) response limiting output rise. This study sought investigate whether chronotropic incompetence (CI) blunted HR recovery would prevalent with mutant transthyretin (ATTRv) cardiomyopathy.Methods results: Eighteen ATTRv (Val122Ile) (72 ± 8-year) 15 age-matched controls (73 3-year) were prospectively enrolled. Patients' medical records, pulmonary...
We have evaluated here the clinical and analytical performance of Alere™ Heart Check (AHC) test, a rapid point-of-care immunoassay designed for measurement BNP from fresh capillary whole blood.One-hundred-and-sixty-three patients with stable chronic heart failure followed at cardiac rehabilitation were submitted to simultaneous plasma (Abbott architect system) measurements.Both methods showed good correlation, although values diverged when was higher than 2000 pg/ml. Despite relatively poor...
Background: The exercise pressor reflex, i.e., metabo- and mechano-reflex, partially regulates the control of ventilation cardiovascular function during exercise. Abnormal reflex response has been associated with exaggerated ventilatory drive, sympathovagal imbalance limitation in chronic heart failure patients. Whether metaboreflex is over-activated participate to poor aerobic capacity patients hereditary transthyretin cardiac amyloidosis (CA-TTR) unknown. Methods: Twenty-two CA-TTR (aged...
Pulmonary involvement in individuals with transthyretin cardiac amyloidosis is unclear. The aim of this study was to quantify 99mTc-hydroxy methylene diphosphonate (HMDP) lung retention hereditary (ATTRv) patients and relate tracer uptake intensity pulmonary function aerobic capacity.We prospectively enrolled 20 biopsy-proven ATTRv control subjects. Cardiac confirmed by echocardiography nuclear imaging using 99mTc-HMDP. Semi-quantitative analysis the heart, rib assessed a simple region...
Intracardiac masses may be revealed by an ischemic cerebrovascular accident (stroke). They are sometimes difficult to differentiate echocardiography. Determining their nature is a crucial aspect of patient management. We here report the case 58-year-old man with untreated hypertension, active smoking, history psoriasis, chronic obstructive pulmonary disease (COPD) and nodule in left upper lobe suspected lung cancer. He was hospitalized for stroke which treated thrombolysis, resulting...
Aims: Cardiac amyloidosis (CA) is associated with amyloid infiltration of extra-cardiac tissue, which may occur at early stages the disease. This study evaluates diagnostic utility thoracic fat pad biopsy obtained during pacemaker or ICD implantation as an alternative to standard criteria for systemic amyloidosis. Methods and results: exploratory, retrospective included 27 patients suspected diagnosed cardiac who underwent defibrillator therapy. Of these, 16 were confirmed have CA (15...
The link between transthyretin cardiac amyloidosis (CATTR), and cerebral ischemic events (CIE) has only been hinted at till now, impeding progress in patient management. We seek to evaluate the frequency characteristics of CIE Afro-Caribbean patients followed for CATTR our institution.In this single-center retrospective observational study, July 2005 October 2019 were included. Occurrence was investigated, their cardioembolic origin determined. Analysis conducted according profiles.Overall,...
Background and objective: Along with impaired aerobic capacity, increased slope of the relationship between ventilation (V E ) pulmonary CO 2 output (VCO ), i.e., V -VCO is a common finding in patients cardiac amyloidosis (CA), which suggests ventilatory inefficiency. Little known about mechanisms leading to inefficiency CA patients. The purpose this investigation was examine factors that underlie abnormal efficiency transthyretin hereditary patients, such as excessive drive, inability blood...
Background: Notch3, a receptor expressed in vascular smooth muscle cells (VSMC), plays key role the integrity of resistance arteries by controlling maturation VSMC through RBPJk, canonical Notch transcriptional factor. We hypothesized that Notch3 signaling pathway VSMCs coronary might play cardiac adaptation to pressure-overload. Methods: To eliminate congenital defect biases, we used mice which conditional tamoxifen- selective deletion RBPJk was induced at age 4 weeks (SMMHC-CRE ER T2,...
The likely pathogenic variant c.407A>T p.Asp136Val of the LMNA gene has been recently described in a young woman presenting with atypical progeroid syndrome, associated severe aortic valve stenosis. We further describe cardiovascular involvement syndrome her family. identified seven members general presentation suggestive syndrome. All them presented heart conduction abnormalities: degenerative cardiac diseases such as coronary artery disease (two subjects) and stenosis (three occurred...