A5080383793- Methane Hydrates and Related Phenomena
- Spacecraft and Cryogenic Technologies
- Pregnancy and Medication Impact
- Infant Nutrition and Health
- Inflammatory Bowel Disease
- Astro and Planetary Science
- Gut microbiota and health
- Astronomical Observations and Instrumentation
- Offshore Engineering and Technologies
- Geophysics and Gravity Measurements
- Astronomy and Astrophysical Research
- Gamma-ray bursts and supernovae
- RNA modifications and cancer
- Diverticular Disease and Complications
- Microscopic Colitis
- Adolescent and Pediatric Healthcare
- Planetary Science and Exploration
- RNA and protein synthesis mechanisms
- Solar and Space Plasma Dynamics
- Bacterial Genetics and Biotechnology
- Geology and Paleoclimatology Research
- Plant Pathogens and Fungal Diseases
- Plant Pathogens and Resistance
- Scientific Research and Discoveries
- Geomagnetism and Paleomagnetism Studies
Harvard Global Health Institute
2024
Icahn School of Medicine at Mount Sinai
2017-2023
Harvard University
2020-2023
Mount Sinai Hospital
2019
Skidmore College
2013-2016
Western Sydney University
2002-2009
Background and aims Prenatal early life bacterial colonisation is thought to play a major role in shaping the immune system. Furthermore, accumulating evidence links exposures risk of developing IBD later life. We aimed assess effect maternal on composition microbiome during pregnancy offspring’s microbiome. Methods prospectively examined diversity taxonomy pregnant women with without their babies at multiple time points. evaluated diagnosis, mode delivery, antibiotic use feeding behaviour...
Crohn's disease (CD), a type of inflammatory bowel (IBD), is chronic condition the gastrointestinal tract that caused by loss mucosal tolerance towards commensal bacteria resulting in responses. It has long been postulated gut microbiota, complex and dynamic population microorganisms, plays key role pathogenesis IBD. Maternal diagnosis IBD identified as greatest risk factor for offspring increasing odds developing >4.5-fold. Moreover, babies born to mothers with have demonstrated reduced...
Herein we analysed the influence of early life factors, including breast milk composition, on development intestinal microbiota infants born to mothers with and without IBD.
Synthesis of asparaginyl-tRNA (Asn-tRNA(Asn)) in bacteria can be formed either by directly ligating Asn to tRNA(Asn) using an synthetase (AsnRS) or synthesizing on the tRNA. In latter two-step indirect pathway, a non-discriminating aspartyl-tRNA (ND-AspRS) attaches Asp and amidotransferase GatCAB transamidates similarly used for Gln-tRNA(Gln) formation. Most are predicted use only one route Asn-tRNA(Asn) Given that Bacillus halodurans subtilis encode AsnRS formation synthetases synthesize...
The Kiribati 2019 Integrated Household Income and Expenditure Survey (Integrated HIES) embeds novel ecological human health research into an ongoing social economic survey infrastructure implemented by the Pacific Community in partnership with national governments. This study seeks to describe status of a large, nationally representative sample geographically socially diverse I-Kiribati population through multiple clinical measurements detailed socio-economic surveys, while also conducting...
This paper is a brief review of recent studies on the feasibility using olive mill solid waste (OMW) as major ingredient in preparation humified compost (HC), and application HC to soil growth horticultural crops such Olea europaea (olive), Lycopersicon esculentum (tomato), Lactuca sativa (lettuce), Fragaria vesca (strawberry) Agaricus bisporus (white button mushroom). OMW-based subjected thermal composting process resulted significant decrease level polyphenols making it non-phytotoxic....
Introduction: Poor diet is among the top risk factors for cardiometabolic disease, which disproportionately burdens South Asians. In 2019, EAT-Lancet Commission proposed a Planetary Health Diet (PHD) designed to optimize human and global environmental health. Objective: We examined associations between novel Index (PHDI), that reflects adherence recommendations, in prospective cohort of Asians US. Methods: included participants from MASALA study with complete baseline (n=891) 5-year...
Monitoring IBD activity during pregnancy is challenging because clinical and laboratory markers may be altered due to the physiological adaptation that occurs, endoscopy use limited. Fecal Lactoferrin (FL) a non-invasive biomarker of gut inflammation used for diagnostics management IBD; however, little known about its in pregnant women. Herein, we investigated FL concentrations control women, participating MECONIUM (Exploring MEChanisms Of disease traNsmission In Utero through Microbiome)...
There is an increased risk of IBD in children born to mothers with IBD. We previously showed that babies had evidence gut microbiota dysbiosis at birth persisted up 3 months life. Herein, we investigated FC concentrations as a biomarker inflammation or without during their first year life, participating the MECONIUM (Exploring MEChanisms Of disease traNsmission In Utero through Microbiome) study. 243 infant stool samples obtained 2 weeks (2w), (2m) and 1 (1y) from 122 (33 IBD) were analysed...
Background: Human studies have demonstrated changes in the diversity and abundance of microbiome during pregnancy coinciding with maternal immune status. Furthermore, accumulating evidence suggests that health may influence newborn's development. These balancing acts be even more complicated pregnant women IBD, who exhibit a variety immunological gut microbiota alterations. Yet, no data exist on effect IBD pregnancy, its role infant composition. Methods: The “Exploring MEChanisms Of disease...
of ECCO -European Crohn's and Colitis Organisation S087Conclusions: Tollip promotes colitis-associated carcinogenesis despite being protective against colitis.Our data suggest that favours leukocytes infiltration in the colonic mucosa, potentially via regulation inflammatory migration
Environmental factors are thought to play a major role in the pathogenesis of inflammatory bowel disease (IBD). Importantly, increasing epidemiological evidence suggests that exposures occurring during early life may be determinant development. However, studying this window susceptibility is challenging, and very little has been elucidated about environmental preceding onset. Teeth develop an incremental manner, storing information on compounds such as metals organics we age. The study...
Abstract Background IBD often affects women during their reproductive years; however, the effect of pregnancy on disease course remains poorly understood. We aimed to assess intestinal inflammation in patients compared with controls as measured by faecal calprotectin (FC). also investigated whether maternal diagnosis was associated altered FC offspring and if there were particular bacterial taxa that correlated levels. Methods Pregnant or without infants prospectively enrolled MECONIUM study...