A5002303091- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Blood Pressure and Hypertension Studies
- Venous Thromboembolism Diagnosis and Management
- Acute Ischemic Stroke Management
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Acute Myocardial Infarction Research
- Cardiovascular Effects of Exercise
- Cardiac tumors and thrombi
- Heart Rate Variability and Autonomic Control
- Sports injuries and prevention
- Cardiac Structural Anomalies and Repair
- Healthcare Systems and Public Health
- Optimism, Hope, and Well-being
- Cardiac Health and Mental Health
- Psychological Well-being and Life Satisfaction
- Medication Adherence and Compliance
- Health, psychology, and well-being
- Cerebrovascular and Carotid Artery Diseases
- Takotsubo Cardiomyopathy and Associated Phenomena
- Sodium Intake and Health
University of Turku
2021-2025
Turku University Hospital
2021-2025
University of Helsinki
2023
Helsinki University Hospital
2023
Contemporary data have shown a decrease in the ischaemic stroke risk associated with female sex patients atrial fibrillation (AF). We evaluated temporal trends predictive value of non-sex CHA
Abstract Background and Aims Female sex has been linked with higher risk of ischaemic stroke (IS) in atrial fibrillation (AF), but no prior study examined temporal trends the IS associated female sex. Methods The registry-linkage Finnish AntiCoagulation Atrial Fibrillation (FinACAF) included all patients AF Finland from 2007 to 2018. Ischaemic rates rate ratios were computed. Results Overall, 229 565 new-onset identified (50.0% women; mean age 72.7 years). crude incidence was women than men...
Graphical AbstractCHA2DS2-VASc [congestive heart failure, hypertension, age ≥75 years (doubled), diabetes, stroke/transient ischaemic attack/thromboembolism vascular disease, 65–74 years, sex category (female)]; CHA2DS2-VA years]; CHD-VASc CHD-VA years].Open in new tabDownload slide
KEJA: Speaker: Bayer, Pfizer and Boehringer-Ingelheim. Research grants from the Finnish Foundation for Cardiovascular Clinical Fund of Turku University Hospital; VL: grant State Funding Hospital expert responsibility area; KT: none. GYHL: Consultant speaker BMS/Pfizer, Boehringer Ingelheim, Daiichi-Sankyo, Anthos. No fees are received personally. He is a National Institute Health Care (NIHR) Senior Investigator co-PI AFFIRMO project on multimorbidity in AF (grant agreement 899871), TARGET...
Abstract Aims Little is known about the effects of mental health conditions (MHCs) on utilization oral anticoagulation (OAC) therapy in atrial fibrillation (AF) patients. We aimed to assess whether MHCs affect initiation OAC among AF patients with special focus non-vitamin K antagonist anticoagulants (NOACs). Methods and results The Finnish AntiCoagulation Atrial Fibrillation (FinACAF) registry included all 239 222 diagnosed incident during 2007–18 Finland identified from national registries...
Guidelines on the management of atrial fibrillation (AF) have evolved significantly during past two decades, but concurrent developments in real-life and prognosis AF are unknown. We assessed trends treatment outcomes patients with incident between 2007 2017.The registry-based nationwide FinACAF (Finnish AntiCoagulation Atrial Fibrillation) cohort covers all Finland from levels care. determined proportion who were treated oral anticoagulants (OACs) or rhythm control therapies, experienced an...
Cardiac troponin levels are elevated in Takotsubo syndrome (TTS) with significant overlap to acute myocardial infarction (MI). Long and intact cardiac T (cTnT) forms typical for MI. This study sought assess whether the fragmentation composition of cTnT release TTS differs from
Background
Abstract Background Direct oral anticoagulants (DOACs) at reduced dosage regimens are the first choice of ischaemic stroke (IS) prevention for patients with atrial fibrillation (AF) and elevated bleeding risk or renal insufficiency. We compared outcomes dose DOACs warfarin. Methods results included all new-onset AF in Finland from 2011 to 2018. Adjusted hazard ratios (HR) IS, intracranial haemorrhage (ICH), bleeding, mortality were calculated dabigatran (n=2 672), rivaroxaban (n=1 866),...
To investigate sex-specific temporal trends in the initiation of oral anticoagulant (OAC) therapy among patients diagnosed with atrial fibrillation (AF) Finland between 2007 and 2018.The registry-linkage Finnish AntiCoagulation Atrial Fibrillation (FinACAF) Study included all incident AF from to 2018. The primary outcome was any OAC therapy.We identified 229,565 new-onset (50.0% women; mean age 72.7 years). increased continuously during observation period. While women were more likely...
Journal Article Corrected proof Temporal trends in hypertension-related ischaemic stroke risk atrial fibrillation from 2007 to 2018: a nationwide cohort study Get access Konsta Teppo, Teppo Heart Centre, Turku University Hospital, of Turku, Hämeentie 11, 20540, Finland Corresponding author. Tel: 00358415027333. Email: jkitep@utu.fi https://orcid.org/0000-0002-4460-0994 Search for other works by this author on: Oxford Academic Google Scholar Ville Langén, Langén Division Medicine,...
Abstract Low socioeconomic status has been associated with poor outcomes in patients atrial fibrillation (AF). However, little is known about disparities adherence to stroke prevention direct oral anticoagulants (DOACs). We assessed the hypothesis that AF higher income or educational levels have better DOACs terms of treatment implementation and persistence. The used nationwide registry‐based FinACAF cohort covers all incident starting Finland during 2011–2018. analyses included 74 222 (mean...
In patients with atrial fibrillation (AF), socioeconomic disparities have been reported in the use of oral anticoagulant therapy and outcomes, but whether income also affects utilization antiarrhythmic therapies (AATs) for rhythm control is unknown. We assessed hypothesis that AF higher are more likely to receive AATs.
Background Mental health conditions (MHCs) are associated with poor outcomes in patients atrial fibrillation. However, persistence of oral anticoagulation therapy fibrillation and MHCs is unknown. We aimed to evaluate the effect on direct anticoagulant (DOAC) use based a nationwide cohort. Methods Results The registry‐based FinACAF (Finnish Anticoagulation Atrial Fibrillation) cohort included 67 503 incident indication for permanent (CHA 2 DS ‐VASc score >1 men >2 women) starting DOAC...
Background Socioeconomic disparities can be associated with adverse outcomes in patients cardiovascular diseases. The impact of personal income on the atrial fibrillation (AF) is unclear. Methods Nationwide observational registry-based study incident AF Finland during 2007–2018. Results 203 154 (mean age 73.0±13.5; females 49.0%) were diagnosed period. Overall, 16 272 (8.0%) experienced first-ever ischaemic stroke and 63 420 (31.2%) died follow-up 4.3±3.3 years). After adjusting for...
Medication adherence is essential for effective stroke prevention in patients with atrial fibrillation (AF). We aimed to assess whether direct oral anticoagulants (DOACs) AF affected by the presence of mental health conditions (MHCs). The nationwide FinACAF cohort covered 74,222 from all levels care receiving DOACs during 2011–2018 Finland. possession ratio (MPR) was used quantify adherence. Patients MPR ≥0.90 were defined adherent. MHCs interest depression, bipolar disorder, anxiety...
Abstract Aims Elective cardioversion (ECV) is routinely used in atrial fibrillation (AF) to restore sinus rhythm. However, it includes a risk of thromboembolism even during adequate oral anticoagulation treatment. The aim this study was evaluate the thromboembolic and bleeding complications after ECV real-life setting utilizing data from large AF population. Methods results This nationwide register-based included all (n = 9625) Finnish patients undergoing their first-ever between 2012 2018....
Objectives Elevations of cardiac troponin T (cTnT) levels are common after strenuous exercise. We assessed whether the composition cTnT release marathon race differs from that acute myocardial infarction (MI). Methods Troponin was analysed in plasma samples taken 45 runners and 84 patients with type 1 MI. The concentration long (intact mildly fragmented cTnT) measured a novel upconversion luminescence immunoassay, total commercial high-sensitivity assay, ratio to (troponin ratio) determined...
Atrial fibrillation (AF) patients with mental health conditions (MHCs) have higher incidence of ischaemic stroke (IS) than without MHC, but whether this results from direct impact MHCs or relates to prevalence comorbidities and differences in the use oral anticoagulant (OAC) therapy is unclear. We assessed hypothesis that independently increase risk IS incident AF.The nationwide FinACAF cohort covered all 203,154 diagnosed AF previous transient attack Finland during 2007-2018. interest were...
BACKGROUND: Limited data exist on the temporal relationship between new-onset atrial fibrillation (AF) and ischemic stroke its impact patients’ clinical characteristics mortality. METHODS: A population-based registry-linkage database includes all patients with AF in Finland from 2007 to 2018. Ischemic temporally associated (ISTAF) was defined as an occurring within ±30 days first diagnosis. Clinical factors ISTAF were studied logistic regression 90-day survival Cox proportional hazards...