A5013432260- Chromosomal and Genetic Variations
- Bat Biology and Ecology Studies
- Evolution and Paleontology Studies
- RNA Research and Splicing
- Prenatal Screening and Diagnostics
- Genetic Syndromes and Imprinting
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Renal and related cancers
- HIV Research and Treatment
- CRISPR and Genetic Engineering
- Wildlife Ecology and Conservation
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Pregnancy and preeclampsia studies
- interferon and immune responses
- Fish Ecology and Management Studies
- Physiological and biochemical adaptations
- Solar Radiation and Photovoltaics
- Virology and Viral Diseases
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Energy and Environment Impacts
- Hybrid Renewable Energy Systems
- Animal Genetics and Reproduction
- Amphibian and Reptile Biology
Stanford University
2017-2023
Centre National de la Recherche Scientifique
2011-2018
Université Paris-Sud
2011-2018
Institut Gustave Roussy
2011-2016
Université Paris Cité
2013-2016
Délégation Paris 7
2013-2016
Sorbonne Paris Cité
2013-2016
Syncytins are envelope genes of retroviral origin that have been co-opted for a role in placentation and likely contribute to the remarkable diversity placental structures. Independent capture events identified primates, rodents, lagomorphs, carnivores, where they involved formation syncytium layer at fetomaternal interface via trophoblast cell–cell fusion. We searched similar within suborder Ruminantia placenta lacks an extended but displays heterologous cell-fusion process unique among...
Significance Syncytins are “captured” genes of retroviral origin, corresponding to the fusogenic envelope gene endogenized retroviruses. They present in a series eutherian mammals, including humans and mice where they play an essential role placentation. Here we show that marsupials—which diverged from mammals ∼190 Mya but still possess primitive, short-lived placenta (rapidly left by embryo for development external pouch)—have also captured such genes. The characterization syncytin-Opo1...
Syncytins are envelope protein genes of retroviral origin that have been captured for a function in placentation. Two such already identified simians, two distinct, unrelated Muridae, and fifth gene has the rabbit. Here, we searched similar Laurasiatheria clade, which diverged from Euarchontoglires—primates, rodents, lagomorphs—shortly after mammalian radiation (100 Mya). In silico search with full-coding capacity within dog cat genomes several candidate genes, one common to both species...
Significance Retroviral envelope gene capture and exaptation for a placental function has been demonstrated in mammals. Remarkably, structures have also emerged on rare occasions nonmammalian vertebrates, resulting related modes of reproduction. The Mabuya lizard, which 25 Mya, possesses placenta closely to that Here, we identified specific retroviral shows all the characteristic features bona fide mammalian syncytin, being conserved evolution, expressed placenta, fusogenic. Together with...
Syncytins are envelope genes of retroviral origin that have been co-opted for a role in placentation. They promote cell–cell fusion and involved the formation syncytium layer—the syncytiotrophoblast—at materno-fetal interface. were captured independently eutherian mammals, knockout mice demonstrated they absolutely required placenta embryo survival. Here we provide evidence these "necessary" acquired "by chance" definite lifetime with diverse fates depending on animal lineage, being both...
Significance Syncytins are genes of retroviral origin that have been captured by their host as symbionts for a function in placentation. They can mediate cell–cell fusion, consistent with ancestral envelope gene status, and involved fusion mononucleate trophoblast cells to form the syncytial layer—the syncytiotrophoblast—of feto–maternal interface. We proposed such pivotal emergence placental mammals from egg-laying animals should be present all along Placentalia radiation. searched...
Syncytin genes are fusogenic envelope protein (env) of retroviral origin that have been captured for a function in placentation. Within rodents, two such previously identified the mouse-related clade, allowing demonstration their essential role via knockout mice. Here, we searched similar second major clade Rodentia order, squirrel-related taking advantage complete sequencing ground squirrel Ictidomys tridecemlineatus genome. In silico search env with full coding capacity several candidate...
Eutherians are often mistakenly termed ‘placental mammals’, but marsupials also have a placenta to mediate early embryonic development. Lactation is necessary for both infant and fetal development in eutherians marsupials, although far more complex milk repertoire that facilitates morphogenesis of developmentally immature young. In this study, we demonstrate the anatomically simple tammar expresses dynamic molecular program reminiscent eutherian placentation, including maternal signals....
Long non-coding RNAs (lncRNAs) are widely expressed and play various roles in cell homeostasis. However, because of their low conservation at the sequence level, recapitulating lncRNA evolutionary history is often challenging. While performing an ultrastructural analysis viral particles present uterine glands gestating opossum females, we serendipitously noticed presence numerous structures similar to paraspeckles, nuclear bodies which human mouse cells assembled around architectural...
Capture of retroviral envelope genes from endogenous retroviruses has played a role in the evolution mammals, with evidence for involvement these formation maternofetal interface placenta. It been shown that diversity captured is likely to be responsible placental structures, ranging poorly invasive (epitheliochorial) highly (hemochorial), an intermediate state (endotheliochorial) as found carnivorans. The latter recapitulate part this evolution, hyena being sole carnivoran hemochorial In...
ABSTRACT Retroviruses enter host cells through the interaction of their envelope (Env) protein with a cell surface receptor, which triggers fusion viral and cellular membranes. The sodium-dependent neutral amino acid transporter ASCT2 is common receptor large RD114 retrovirus interference group, whose members display frequent env recombination events. Germ line infections have led to numerous inherited endogenous retroviruses (ERVs) in vertebrate genomes, provide useful insights into...
Background A large fraction of vertebrate genomes is composed endogenous retroviruses (ERVs), which are remnants ancient retroviral infections. In mammals, five envelope genes with a placenta-specific expression and fusogenic activity, the syncytins, have been independently “captured” in primates, rodents lagomorphs (which all Euarchotonglires mammals) conserved over more than 30 million years functional state. They involved formation syncytiotrophoblast, necessary for placental development....