A5052286621- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Clinical Nutrition and Gastroenterology
- Cytomegalovirus and herpesvirus research
- Liver Disease and Transplantation
- Transplantation: Methods and Outcomes
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Child Nutrition and Feeding Issues
- Central Venous Catheters and Hemodialysis
- Eosinophilic Esophagitis
- Organ and Tissue Transplantation Research
- Multiple and Secondary Primary Cancers
- Viral gastroenteritis research and epidemiology
- Pediatric Hepatobiliary Diseases and Treatments
- Immunodeficiency and Autoimmune Disorders
- Acute Kidney Injury Research
- Liver Diseases and Immunity
- Hepatitis Viruses Studies and Epidemiology
- Hemoglobinopathies and Related Disorders
- Antibiotics Pharmacokinetics and Efficacy
- Nutrition and Health in Aging
- Iron Metabolism and Disorders
- Reproductive System and Pregnancy
- Lung Cancer Treatments and Mutations
Cedars-Sinai Medical Center
2023-2025
Medical University of Lodz
2024
University of California, Los Angeles
2013-2022
Mattel Children's Hospital
2011-2022
Ronald Reagan UCLA Medical Center
2022
UCLA Medical Center
2022
UCLA Health
2013-2017
Development Fund
2016
Terasaki Foundation
2016
Helsinki University Hospital
2013
Probiotic strains of Lactobacillus are currently used in a variety clinical practices with limited evidence to support their use. species normal part gastrointestinal flora, and bacteremia probiotic is very uncommon. We describe case 17-year-old boy ulcerative colitis managed systemic corticosteroids infliximab, who presented fever 102°F, flushing, chills 1 week after starting rhamnosus GG probiotics. Initial blood culture on day 2 his was positive for Lactobacillus, however, subsequent...
The role of donor-specific HLA antibodies (DSA) after pediatric liver transplantation (LTx) is not clearly established. We completed a cross-sectional study to characterize DSA in long-term survivors LTx and assess the impact C1q-binding on allograft outcomes.Serum samples were collected at routine clinic visits from 50 recipients classified into 3 clinical phenotypes: nontolerant (n = 18) with de novo autoimmune hepatitis (DAIH) and/or late acute cellular rejection (ACR); stable 25)...
To identify biomarkers of operational tolerance in pediatric and adult liver transplant recipients, transcriptional profiles were examined from 300 samples by microarrays Q-PCR measurements blood specimens recipients normal tissues. Tolerance-specific genes validated independent across two different programs Q-PCR. A minimal set 13 unique genes, highly expressed natural killer cells (p = 0.03), significantly both tolerance, irrespective clinical demographic confounders. The performance this...
In Brief Background Rejection remains the leading cause of allograft loss, and a major barrier to improving long-term outcomes after intestinal transplantation. Our aim is define prevalence investigate role donor-specific antibody (DSA) on graft outcomes. Methods The study includes 109 transplants performed in 95 recipients at single center. Patients were screened for DSA pretransplant, monitored regularly posttransplant when clinically indicated using single-antigen bead Luminex assay....
Abstract OBJECTIVE The comorbid diagnoses of eosinophilic esophagitis (EoE) and inflammatory bowel disease (IBD) are reported increasingly. Few studies have investigated EoE-IBD co-occurrence in children specifically. We aimed to describe the clinical characteristics, risk factors, outcomes disease-specific therapy patients diagnosed with both EoE IBD. METHODS conducted a retrospective, single-center review followed Pediatric IBD Program at Cedars-Sinai. collected data from Jan 2008 2023...
Next-generation sequencing has enabled precision therapeutic approaches that have improved the lives of children with rare diseases. Congenital diarrhea and enteropathies (CODEs) are associated high morbidity mortality. Although treatment these disorders is largely supportive, emerging targeted therapies based on genetic diagnoses include specific diets, pharmacologic treatments, surgical interventions. We analyzed exomes or genomes infants suspected monogenic congenital diarrheal disorders....
Background. Human leukocyte antigen (HLA)-G displays immunotolerogenic properties toward the main effector cells involved in graft rejection through inhibition of natural killer cell- and cytotoxic T-lymphocyte-mediated cytolysis, CD4+ T-cell alloproliferation. An increase serum levels HLA-G has been noted transplant patients with improved allograft survival. However, clinical relevance soluble molecules tolerant pediatric young adult liver remains to be studied. Methods. We examined 42 a...
Advances in intestinal transplantation (ITx) have resulted improved survival and the opportunity to examine nutritional outcomes. The aim of this study was describe detailed, long-term results identify positive predictors growth weight gain following pediatric ITx.A single-center retrospective, Institutional Review Board-approved review a prospective database conducted. Inclusion criteria were ITx recipients 18 years or younger with 6 months more. Outcomes included anthropometric...
Home parenteral nutrition (PN) is a lifesaving therapy for children with intestinal failure (IF). Our aims were to describe the prevalence of micronutrient deficiencies (vitamin D, zinc, copper, iron, selenium) in diverse population IF receiving PN and identify characterize risk factors associated deficiencies, including hematologic abnormalities.Data collected on 60 eligible patients through retrospective chart review between May 2012 February 2015. Descriptive statistics included...
Newborns and infants are often exposed to painful procedures during hospitalization. Several different scales have been validated assess pain in specific populations of pediatric patients, but no single scale can easily accurately all newborns regardless gestational age disease state. A new was developed, the COVERS scale, which incorporates 6 physiological behavioral measures for scoring. admitted Neonatal Intensive Care Unit or Well Baby Nursery were evaluated pain/discomfort two...
Biopsies remain the criterion standard in diagnosis of intestinal transplant (ITx) rejection, and gastrointestinal endoscopy plays a pivotal role patient management. Herein, we describe single-center 23-year endoscopic experience pediatric ITx recipients.A retrospective review pathology reports all recipients <18 years old transplanted between 1991 2013 was performed with aim describing procedural indications, findings, complications.A total 1770 procedures within 1014 sessions were...
Abstract Post‐transplant lymphoproliferative disease ( PTLD ) has the highest incidence following intestinal transplantation IT x). Our center seen a recent increase in . aim was to review single‐center experience with focus on clinical characteristics and outcomes. We completed retrospective of biopsy‐proven cases using prospectively maintained database 115 x recipients transplanted between 1991 2014. Nineteen (17%) developed 25 during median follow‐up time 6.4 (1.6‐14.6) years. The early...
Background: Vitamin D plays important roles in both skeletal and nonskeletal health. Limited data suggest that patients with intestinal failure (IF) receiving home parenteral nutrition (PN) are at risk for vitamin deficiency due to inadequate oral intake, poor absorption, chronic illness. The purpose of this study was document status pediatric IF PN. Materials Methods : We performed a 2‐year retrospective review children followed our center who had been on PN ≥6 months ≥1 serum...
ABSTRACT Objective: Recent studies show increased serum and esophageal IgG4 in patients with eosinophilic esophagitis (EoE), suggesting a possible IgG4‐involved process. The role of pediatric EoE has not been extensively investigated. Our aim was to analyze tissue children parallel that adults EoE. Methods: In retrospective institutional review board–approved study, we performed immunohistochemical staining biopsy specimens from 39 subjects: (n = 16), 15), reflux 4), controls 4). We assessed...
A growing body of evidence shows that donor-specific antibodies (DSA) are associated with rejection and allograft failure following both liver intestinal transplantation. However, data have clearly shown not all DSA injurious. The reasons for this remain unclear but appear to be multifactorial, impacted by clinical factors such as immunosuppression infection well immunologic HLA expression affinity. Establishing a diagnosis antibody-mediated (AMR) remains clinically challenging, especially...
Despite recent advances in intestinal transplantation (ITx), infection (INF) and acute cellular rejection (ACR) remain major causes of patient graft loss. Studies other solid-organ transplantations indicate that low levels serum immunoglobulin G (IgG) negatively impact outcomes. To date, there have been no studies on IgG after ITx.A retrospective review an measurement protocol primary ITx recipients between 2007 2011 was undertaken. were measured at the time evaluation, transplantation,...
Background. Angiotensin II type-1 receptor (AT1R) antibodies have been associated with rejection and allograft loss in solid organ transplantation may act synergistically HLA donor-specific (DSA). Our aims were to assess the prevalence of AT1R determine if they dysfunction pediatric liver transplant recipients. Methods. We performed a retrospective, cross-sectional study DSA 2 cohorts recipients: stable control cohort normal function (n = 70) who consented serum samples collected for...
Abstract The significance of post‐transplant HLA DSA and chronic AMR in LT is an emerging field study. Although OPV has previously been described as a histopathologic finding DSA‐positive adult recipients, it was not included the recent Banff criteria for AMR. Our aim to describe association between pediatric recipients. A retrospective review 67 liver biopsies performed November 2014 April 2016 45 recipients identified four patients with OPV. Clinical status, biochemistry, presence DSA,...
Abstract Background Few studies have examined the epidemiology and risk factors for development of outpatient‐acquired catheter‐related bloodstream infections (CRBSIs) in children receiving home parenteral nutrition. This study aimed to (1) characterize incidence, clinical presentation, CRBSIs (2) identify Methods A longitudinal database approved by our Institutional Review Board was created prospectively track UCLA pediatric population from January December 2012. Eligible patients included...
Background: Daratumumab (Dara) is the first monoclonal antibody introduced into clinical practice to treat multiple myeloma (MM). It currently forms backbone of therapy regimens in both newly diagnosed (ND) and relapsed/refractory (RR) patients. However, previous reports indicated an increased risk infectious complications (ICs) during Dara-based treatment. In this study, we aimed determine profile ICs MM patients treated with establish predictors their occurrence. Methods: This...