A5049588056- Polysaccharides Composition and Applications
- Hydrogels: synthesis, properties, applications
- Polysaccharides and Plant Cell Walls
- Advanced Drug Delivery Systems
- Lipid Membrane Structure and Behavior
- Proteins in Food Systems
- Surfactants and Colloidal Systems
- 3D Printing in Biomedical Research
- biodegradable polymer synthesis and properties
- Advancements in Transdermal Drug Delivery
- Protein Interaction Studies and Fluorescence Analysis
- Analytical Chemistry and Chromatography
- Chemical Synthesis and Analysis
- Inhalation and Respiratory Drug Delivery
- Food composition and properties
- Neonatal Respiratory Health Research
- Microfluidic and Capillary Electrophoresis Applications
- Analytical Chemistry and Sensors
- Drug Solubulity and Delivery Systems
- Proteoglycans and glycosaminoglycans research
- Advanced Polymer Synthesis and Characterization
- Chemical Reaction Mechanisms
- Magnetic and Electromagnetic Effects
- Synthesis and Characterization of Heterocyclic Compounds
- Enzyme Production and Characterization
Sapienza University of Rome
2008-2022
University of Rome Tor Vergata
2008
Magna Graecia University
2008
University of Siena
1996
University of Cagliari
1992-1995
Istituto di Farmacologia Traslazionale
1975-1993
Istituto di Chimica Biomolecolare
1967
Bioprinting is a recent technology in tissue engineering used for the design of porous constructs through layer-by-layer deposition cell-laden material. This would benefit from new biomaterials that can fulfill specific requirements fabrication well-defined 3D constructs, such as preservation cell viability and adequate mechanical properties. We evaluated suitability novel semi-interpenetrating network (semi-IPN), based on hyaluronic acid hydroxyethyl-methacrylate-derivatized dextran...
Innovative hydrogels obtained by physical and chemical crosslinking of deacylated Gellan gum have been characterized in terms water uptake, rheological properties compressibility, the behaviour tested materials, according to type network, is thoroughly discussed. The release from various gels loaded model molecules different steric hindrance was also investigated trend profiles has related structures proposed for hydrogel.
In situ forming hydrogels, which allow for the modulation of physico-chemical properties, and in cell response can be tailored, are providing new opportunities biomedical applications. Here, we describe interpenetrating polymer networks (IPNs) based on a physical network calcium alginate (Alg-Ca), interpenetrated with chemical one hydroxyethyl-methacrylate-derivatized dextran (dex-HEMA). IPNs different concentration degree substitution dex-HEMA were characterized evaluated protein release as...
ABSTRACT – Purpose. Aim of this research was to prepare and study drug release from a new formulation consisting non ionic surfactant vesicular structures, niosomes (NSVs), loaded with model molecules calcein (CALC), nile red (NR), ibuprofen (IBU) or caffeine (CAFF), embedded in hydrogel matrix. Methods. The system locust bean gum/xanthan (1:1), prepared at 60 °C, used entrap the vesicles (Tween 20/cholesterol 1:1), guest profiles were detected 32 °C. systems characterized by means scanning...
Self-assembled nanohydrogels based on hydrophobically modified polysaccharides have been extensively studied due to their wide potential applications as drug delivery systems. In the present study, we developed and characterized self-assembling sonicated gellan gum chains. Prednisolone (Pred), a poorly water soluble anti-inflammatory drug, was chemically conjugated carboxylic groups of (Ge–Pred) it hydrophobic moiety responsible for process. Ge–Pred by proton nuclear magnetic resonance...
The aim of this work was to investigate the possibility employing Molecularly Imprinted Polymers (MIPs) as a controlled release device for 5-fluorouracil (5-FU) in biological fluids, especially gastrointestinal ones, compared Non (NIPs). MIPs were synthesized using methacrylic acid (MAA) functional monomer and ethylene glycol dimethacrylate (EGDMA) crosslinking agent. capacity polymer recognize bind template selectively both organic aqueous media evaluated. An vitro study performed plasma...
In situ polymerizable hydrogels are extensively investigated to implement new biomedical and pharmaceutical approaches. the present paper a novel polysaccharidic matrix based on calcium alginate (Ca(II)-Alg) hydrogel dextran methacrylate derivative (Dex-MA), showing potential applicability in field of pharmaceutics is described. The semi-interpenetrating polymer system (semi-IPN) obtained by dispersion Dex-MA chains into Ca(II) leads with rheological properties quite different from those...
Guar gum is a galactomannan that assumes very flexible conformation in solution, while Scleroglucan rigid polysaccharide dissolves water as triple helices. Both polymers can form gels the presence of borax. Despite their structural differences, freeze-dried gel systems both polymers, when compressed to tablets, show peculiar anisotropic swelling reflects an amazing similarity terms molecular properies. In this paper behavior Guar/borax compared with Scleroglucan/borax. The macroscopic...
Guar gum (GG) and gum/borax (GGb) hydrogels are studied by means of rheology, Low Field Nuclear Magnetic Resonance (LF NMR) model drug release tests.These three approaches used to estimate the mesh size (!) polymeric network.A comparison with similar Scleroglucan systems is carried out.In case GGb, rheological NMR estimations !lead comparable results, while approach seems underestimate !.Such discrepancy attributed viscous effect some chains that, although bound network one end, can freely...