A5076973847- CAR-T cell therapy research
- Hematopoietic Stem Cell Transplantation
- RNA Interference and Gene Delivery
- Epoxy Resin Curing Processes
- Acute Lymphoblastic Leukemia research
- Synthesis and properties of polymers
- Immune Cell Function and Interaction
- Virus-based gene therapy research
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- Reproductive biology and impacts on aquatic species
- Tribology and Wear Analysis
- Educational Technology and Assessment
- Developmental Biology and Gene Regulation
- Intracranial Aneurysms: Treatment and Complications
- Nanoparticle-Based Drug Delivery
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Muscle Physiology and Disorders
- Genetic Syndromes and Imprinting
- Polymer composites and self-healing
- DNA and Nucleic Acid Chemistry
- Cancer therapeutics and mechanisms
- Ovarian cancer diagnosis and treatment
- Head and Neck Cancer Studies
- Oral and Maxillofacial Pathology
Chinese PLA General Hospital
2020-2024
Hainan General Hospital
2023
Hainan Medical University
2023
China Pharmaceutical University
2018-2022
Changzhi Medical College
2008-2018
Nanjing Library
2018
Academy of Military Medical Sciences
2014-2016
Guizhou Electric Power Design and Research Institute
2012
Hunan Normal University
2004
Elderly patients with relapsed and refractory acute lymphoblastic leukemia (ALL) have poor prognosis. Autologous CD19 chimeric antigen receptor-modified T (CAR-T) cells potentials to cure B cell ALL; however, safety efficacy of allogeneic CAR-T are still undetermined. We treated a 71-year-old female ALL who received co-infusion haplo-identical donor-derived CD19-directed mobilized peripheral blood stem (PBSC) following induction chemotherapy. Undetectable minimal residual disease by flow...
Dendritic cells (DCs) based cancer immunotherapy is largely dependent on adequate antigen delivery and efficient induction of DCs maturation to produce sufficient presentation ultimately lead substantial activation tumor-specific CD8+ T cells. Carbon nanotubes (CNTs) have attracted great attention in biomedicine because their unique physicochemical properties. In order effectively deliver tumor antigens trigger a strong anti-tumor immune response, herein, specific target system was assembled...
A synthetic method for preparing a Pluronic F127 (F127)-stabilized graphene (GO) supramolecular hydrogel as safe nanovehicle combination treatment has been studied. Doxorubicin (DOX) model drug is non-covalently bound on the great surface area of GO due to strong π-π interaction, hydrophobic and strongest hydrogen bonding. In vitro release experiments revealed that this F127-stabilized sustained characteristic. Furthermore, showed better in antitumor ability under NIR (near infrared) laser...
Liposome modification by targeting ligands has been used to mediate specific interactions and drug delivery target cells. In this study, a new peptide ligand, CP7, was found be able effectively bind FGFR1 through reverse molecular docking could cooperate with VEGFR3 achieve of A549 CP7 modified on the surface liposome construct targeted safe nanovehicle for therapeutic gene, Mcl-1 siRNA. Due binding between cells, siRNA-loaded liposome-PEG-CP7 showed increased cellular uptake in vitro,...
Addressing the repair and regeneration of large bone defects poses significant challenges in tissue engineering. Despite abundant evidence demonstrating positive role MSCs osteogenesis, their limited osteogenic differentiation ability still needs to be improved. The present study used lipopolysaccharide (LPS) enhance properties ecto‑mesenchymal stem cells (EMSCs). Human nasal respiratory mucosa‑derived EMSCs were cultured on plates stimulated with LPS for 5 days prior undergoing...
Abstract Recently, it was found that in the gynogenetic haploid and diploid embryos of goldfish, which have exactly same genome, condition results obstruction gene expression abnormal development while normal development. A diploid‐dependent regulatory apparatus proposed to regulate expression. To study difference at protein level development, we extracted total proteins both goldfish eye formation stage. Two‐dimensional polyacrylamide gel electrophoresis used separate proteins. The stained...
The sequencing panel composed of 61 target genes was used to explore the related mutation oral squamous cell carcinoma (OSCC) and submucous fibrosis (OSF) cancerization, so as provide a theoretical basis for early diagnosis find most important mutations in OSF more targeted prevention cancerization.A total 74 clinically diagnosed samples were included, including 36 cases OSCC 38 cancer patients. DNA extracted, gene technology analyze frequency pathogenic sites clinical samples.Gene analysis...
Abstract Post-remission strategies for patients with acute lymphoblastic leukemia (ALL) are limited to the multiagent chemotherapy and allogeneic stem cell transplant (allo-SCT), cellular therapies seldom involved. Although combined mismatched granulocyte colony-stimulating factor mobilized peripheral blood mononuclear infusion (microtransplant, MST) has been studied in myeloid leukemia, its efficacy ALL is still undetermined. We enrolled 48 receiving hyper-CVAD-based MST between July 1,...
<title>Abstract</title> This work was supported by grants from the National Natural Science Foundation of China (No. 81800150 to Bo Cai, No. 81670110 Kaixun Hu, and 31500732 Yi Wang), Translational Research Grant NCRCH 2020ZKZB02 Mei Guo), for Young Scientists Chinese PLA General Hospital QNF19043 QNF19041 Wang, QNC19034 22QNFC022 Linjun Sheng). killer (NK) cells have emerged as a promising cellular immunotherapy in treatment cancer patients. Recent research has focused on umbilical cord...
Immunotherapies such as adoptive immune cell infusion and immune-modulating agents are widely used for cancer treatment, the concomitant symptoms, including cytokine release syndrome (CRS) or immune-related adverse events (irAEs), frequently reported. However, clinical manifestations induced by mismatched donor granulocyte colony-stimulating factor mobilized peripheral blood mononuclear (GPBMC) in patients receiving microtransplant (MST) have not yet been well depicted.We analyzed 88 cycles...
Objective To discuss the diagnostic value of human epididymis protein (HE)4, cancer antigen (CA)125 and risk ovarian malignancy algorithm(ROMA) index in accessing to analyze correlation three indicators climical stage cancer. Methods A total 294 patients were subjected study including 108 with , 34 other organ 96 gynecological benign disease, 56 gynecological.Chemiluminescence was used measure serum levels HE4 CA125 before surgery.ROMA calculated . Results ROMA index(61.4±23.2)%...
Objective To explore the imaging features of vertebral artery dissection evolving into dissecting aneurysm. Methods Analyzing clinical data and image one patient with intracranial aneurysm, relevant literatures were reviewed. Results During headache, head computed tomography (CT) scan showed a possible arterial aneurysm at end basilar artery, magnetic resonance (MRI) that there was intersection right artery.Furthermore, on digital subtraction angiography (DSA) image, had linear...
Objective To study the effect of carbamazepine and ENP in treatment epilepsy its influence on intelligence electroencephalogram. Methods Eighty-six patients with were enrolled.According to random number method, they divided into observation group control group, 43 cases each groups.The was given combination ENP, while carbamazepine.The duration epileptic seizure seizures, intelligence, P300 wave amplitude latency, adverse effects compared between two groups. Results The total...