A5056059065- Monoclonal and Polyclonal Antibodies Research
- Fungal Biology and Applications
- Gout, Hyperuricemia, Uric Acid
- Microfluidic and Capillary Electrophoresis Applications
- Metabolomics and Mass Spectrometry Studies
- Cancer Genomics and Diagnostics
- Adipose Tissue and Metabolism
- Nanoparticle-Based Drug Delivery
- Lung Cancer Treatments and Mutations
- Biosensors and Analytical Detection
- Microbial Metabolism and Applications
- Liver Disease Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Advanced Neuroimaging Techniques and Applications
- Phytochemistry and Biological Activities
- Additive Manufacturing and 3D Printing Technologies
- Ferroptosis and cancer prognosis
- Analytical Chemistry and Chromatography
- Modular Robots and Swarm Intelligence
- Biosimilars and Bioanalytical Methods
- Characterization and Applications of Magnetic Nanoparticles
- Advanced Biosensing Techniques and Applications
- Protein purification and stability
- Intraocular Surgery and Lenses
- 3D Printing in Biomedical Research
Shenyang Agricultural University
2024
Panyu District Central Hospital
2022-2023
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2022
Daqing Oilfield General Hospital
2011-2021
Panzhihua University
2021
Ningbo University
2020
Fourth Affiliated Hospital of Harbin Medical University
2011
Harbin Medical University
2011
Southeast University
2006
Scripps Research Institute
1997
Abstract Objective . To identify a Golgi complex autoantigen bound by Sjögren's syndrome (SS) autoantibodies. Methods Serum from patient with secondary SS and anti‐Golgi antibodies was used as probe to isolate complementary DNA (cDNA) insert HeLa cDNA library. Results A 3.7‐kb encoding 56‐kd recombinant protein immunoprecipitated the human serum immune rabbit serum. Western blot analysis showed that sera recognized of 97 kd (golgin‐97), suggesting isolated clone contained partial cDNA. The...
Renal fibrosis is glomerulosclerosis and renal tubulointerstitial caused by the increase of interstitial cells intercellular substances accumulation extracellular matrix, a common pathological manifestation disease progressing to end-stage failure. It has proved that Astragalus polysaccharide (AP) curative effect on disease; however, its therapeutic mechanism still unclear. Metabolomics approach provides an opportunity identify novel molecular biomarkers. The purpose this study changes serum...
Objective. Anti-DFS70 antibodies correlating with the nuclear dense fine speckled (DFS) pattern in HEp-2 indirect immunofluorescence assay (IFA) are less common patients systemic autoimmune rheumatic disease (SARD) than healthy subjects and their clinical associations remain elusive. We hosted a multi-center IFA training program to improve ability of laboratories recognize DFS investigate prevalence relevance anti-DFS70 antibodies. Methods. sera identified by 29 centers China were redirected...
Abstract In this paper, a microfilter device with series of pool and dam structures was designed fabricated. To evaluate the efficiency filter, physical models were established to describe behaviors different kind cells in device. our model, both size effect deformability are considered. As cell depends largely on its excess surface area index (ESI), ESI tumor SPC‐A‐1 measured found be as 61.7–81%. From measurements red blood (RBCs) (44%) white (WBCs) (84–137%), we have calculated ultimate...
Taxifolin (TFN) is an important natural compound with antifibrotic activity; however, its pharmacological mechanism not clear. In this study, our aim to gain insight into the effects of TFN and potential mechanisms in unilateral ureteral obstruction (UUO) animal model using metabolomics approach identify metabolic biomarkers perturbed pathways. Serum analysis by UPLC-Q-TOF/MS was carried out discover changes profile. It showed that has a significant protective effect on UUO-induced renal...
Congenital cataract is the most frequent cause of blindness during infancy or early childhood. To date, more than 40 loci associated with congenital have been identified, including at least 26 genes on different chromosomes inherited cataract. This present study aimed to identify genetic mutation in a six-generation Chinese family affected A detailed history and clinical data members were recorded. total 27 members, 14 13 unaffected individuals recruited. Whole exome sequencing was performed...
This study examines the effectiveness of double-marker analysis for α-fetoprotein (AFP) and β-human chorionic gonadotropin (β-hCG) combined with measurement nuchal fold thickness (NT) in detection Down's syndrome (DS) Mainland Chinese subjects during second trimester prenatal screening.We examined pregnant women a singleton pregnancy between 15 21 weeks gestation who underwent screening DS using AFP β-hCG ultrasound NT. The risk was calculated. A cut-off 1/270 used to define at high-risk DS....
Superparamagnetic polymers (SPMP) microbead was an excellent form fornanosized magnetic particles less than 10nm to realize their potential applications in manyfields. We developed a novel modified suspension polymerization method for the productionof superparamagnetic poly (methacrylate divinylbenzene) (PMA-DVB) microbeads, withamino groups on surface after simple modifications. applied these SPMPmicrobeads establish sandwich enzyme chemiluminence immuno (ECLIA) procedure ofdetecting free...
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Sanghuangprous vaninii is a medicinal macrofungus cultivated extensively in China. Both the mycelia and fruiting bodies of S. have remarkable therapeutic properties, but it remains unclear whether may serve as substitute for bodies. Furthermore, perennial fungus with components that vary significantly depending on growing year Hence, critical to select an appropriate harvest stage specific purpose. With aid Traditional Chinese Medicine Systems Pharmacology Database Analysis Platform (TCMSP),...
Aim: Stabilization of critical reagents by freeze-drying would facilitate storage and transportation at ambient temperatures, simultaneously enable constant reagent performance for long-term bioanalytical support throughout drug development. Freeze-drying as a generic process stable was investigated establishing an universal formulation buffer lyophilization process. Results: Using storage-labile model protein, buffers were evaluated to preserve integrity during the process, retain...
In order to solve the problem of dissolved oxygen concentration control caused by strong nonlinearity, large time delay, time-varying, multivariable coupling and serious uncertainty interference in sewage treatment system, according mathematical model aeration system blower, combined with advantages internal cascade PID control, a two degree freedom strategy is proposed, corresponding designed. This solves that traditional method difficult obtain good effect when blower not accurate. The...
Objective To discuss the diagnostic value of human epididymis protein (HE)4, cancer antigen (CA)125 and risk ovarian malignancy algorithm(ROMA) index in accessing to analyze correlation three indicators climical stage cancer. Methods A total 294 patients were subjected study including 108 with , 34 other organ 96 gynecological benign disease, 56 gynecological.Chemiluminescence was used measure serum levels HE4 CA125 before surgery.ROMA calculated . Results ROMA index(61.4±23.2)%...
Abstract Background: Diffusion tensor imaging (DTI) studies have revealed distinct white matter characteristics of the brain following diseases. Beyond lesion-symptom mapping, recent demonstrated extensive structural and functional alterations remote areas to local lesions caused by stroke in brain. Here, we further investigated changes from a global level using DTI data through multivariate pattern analysis (MVPA) network-based statistic (NBS). Methods: Ten ischemic patients with basal...