A5037955140- Pain Management and Opioid Use
- Pain Mechanisms and Treatments
- Anesthesia and Pain Management
- Management of metastatic bone disease
- Cancer Treatment and Pharmacology
- Cannabis and Cannabinoid Research
- Ultrasound and Hyperthermia Applications
- Pediatric Pain Management Techniques
- Childhood Cancer Survivors' Quality of Life
- Cardiac, Anesthesia and Surgical Outcomes
- Oral health in cancer treatment
- Sleep and Wakefulness Research
- Glycogen Storage Diseases and Myoclonus
- Inflammatory mediators and NSAID effects
- Nausea and vomiting management
- Thyroid and Parathyroid Surgery
- Neuroscience of respiration and sleep
- Cancer, Stress, Anesthesia, and Immune Response
- Spinal Dysraphism and Malformations
- Spinal Hematomas and Complications
- Pain Management and Treatment
- Sympathectomy and Hyperhidrosis Treatments
- Occupational exposure and asthma
- Endometriosis Research and Treatment
- Risk and Portfolio Optimization
Institute of Cancer Research
2014-2025
Royal Marsden Hospital
2015-2025
Thomas Jefferson University
2025
Neurological Surgery
2025
Royal Marsden NHS Foundation Trust
2015-2023
London Clinic
2022
Royal Ottawa Mental Health Centre
2021
Royal Victoria Infirmary
2020
University of Bedfordshire
2018
Unilever (United Kingdom)
2018
Globally, medical cannabis legalization has increased in recent years and is commonly used to treat chronic pain. However, there are few randomized control trials studying indicating expert guidance on how dose administer safely effectively needed.Using a multistage modified Delphi process, twenty global experts across nine countries developed consensus-based recommendations patients with pain.There was consensus that may be considered for experiencing neuropathic, inflammatory, nociplastic,...
Cancer and its treatment exert a heavy psychological physical toll. Of the myriad symptoms which result, pain is common, encountered in between 30% 60% of cancer survivors. Pain survivors major growing problem, impeding recovery rehabilitation patients who have beaten negatively impacting on patients’ quality life, work prospects mental health. Persistent remains challenging to treat successfully. can arise both due underlying disease various treatments patient has been subjected to....
Sarcomatoid cancer of unknown primary site is an aggressive and rare clinical entity associated with poor patient outcomes. We describe a case 69-year-old woman who presented low back pain, right leg weakness, urinary retention, weight loss. Spinal imaging revealed soft tissue mass at the sacral ala infiltrating S2-S4 neural foramina, multifocal marrow replacement lumbosacral spine adjacent bilateral iliac bones. Metastatic workup additional lesions cervicothoracic spine, left proximal tibia...
Introduction: We describe four cases of open spina bifida initially presumed to be “closed” defects in which serial prenatal ultrasound examinations documented the occurrence sac rupture and development Chiari II malformation later pregnancy. Case presentation: In each case, starting from 19-24 weeks’ gestation, showed spinal cystic lesions containing neural elements, but no evidence malformation. The lack hindbrain herniation rendered them ineligible for surgical repair; follow-up imaging...
AimsTo determine quality of life (QoL) outcomes after palliation pain from bone metastases using magnetic resonance-guided high intensity focused ultrasound (MR-guided HIFU), measured the European Organization for Research and Treatment Cancer (EORTC) QLQ-C15-PAL QLQ-BM22 questionnaires.Materials methodsTwenty patients undergoing MR-guided HIFU in an international multicentre trial self-completed questionnaires before on days 7, 14, 30, 60 90 post-treatment. Descriptive statistics were used...
Objective In Britain, consent for surgery is documented using a Department of Health form signed by the surgeon and patient. contrast, anaesthetic procedures have no formalised process. Evidence on process regional anaesthesia, patient perceptions this, scarce outside obstetric practice. We aimed to determine recall interscalene brachial plexus block compared this surgical shoulder arthroplasty. Design Prospective observational survey. Setting A specialist musculoskeletal centre, UK....
To date, the therapeutic use of cannabinoids in chronic pain management remains controversial owing to limited clinical evidence found randomized trials (RCTs), heterogeneous nature indication, and broad range cannabis-based medicinal products (CBMPs) used both experimental observational studies. Here we evaluate patient-reported outcomes (PROMS) a cohort adult patients, diagnosed with diverse etiology, who received adjuvant treatment oral, cannabis-based, magistral formulations between May...
In November 2018, the UK’s Home Office established a legal route for eligible patients to be prescribed cannabis-based products medicinal use in humans (CBPMs) as unlicensed medicines. These include liquid cannabis extracts oral administration (“oils”) and dried flowers inhalation (“flos”). Smoking of CBPMs is expressly prohibited. To date, THC-predominant remain most project Twenty21 (T21), first multi-center, prospective, observational UK patient registry. This observational, prospective...
Background: Treatment for head and neck cancer can frequently be a painful experience with implications patients in terms of quality life, nutrition ultimately treatment outcomes. Pain may arise number reasons this patient group including the influence localised tissue damage from radiotherapy, effects chemotherapeutic agents as well disease process itself. Early identification pain, through screening early analgesic pain management are thought to most appropriate approaches problem. Aim: To...
Pain is a common consequence of childhood cancer. While most research has examined biomedical predictors post-cancer pain, biopsychosocial conceptualisations such as the cancer threat interpretation (CTI) model hold promise for guiding comprehensive pain management strategies. Guided by CTI model, this cross-sectional study evaluated correlates in survivors including threat-related risk factors (bodily monitoring, fear recurrence, help-seeking) and mindsets about body. In preceding three...
This study compared changes in imaging and pain relief between patients with intraosseous, as opposed to extraosseous bone metastases. Both groups were treated palliatively magnetic resonance-guided high-intensity-focused ultrasound (MRgHIFU).
Objective To document longitudinal symptom, quality-of-life and imaging response in patients with recurrent gynecological tumors treated magnetic resonance guided high intensity focused ultrasound (MRgHIFU), compare changes intra- versus extra-pelvic lesions.Methods Eleven symptomatic painful were MRgHIFU (Profound Sonalleve) a prospective single center study (NCT02714621). Pain scores, analgesic intake metrics, whole tumor volume, perfused volume from Gadolinium-enhanced T1W documented...
Exposure to airborne proteins can be associated with the development of immediate, IgE-mediated respiratory allergies, genetic, epigenetic and environmental factors also playing a role in determining likelihood that sensitisation will induced. The main objective this study was determine whether concentrations selected common aeroallergens could quantified air homes using easily deployable, commercially available equipment analytical methods, at low levels relevant risk assessment potential...