A5065820412- Fluorine in Organic Chemistry
- Head and Neck Cancer Studies
- RNA and protein synthesis mechanisms
- Chemical Synthesis and Analysis
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Catalytic Cross-Coupling Reactions
- Head and Neck Surgical Oncology
- Synthesis and Reactivity of Heterocycles
- Synthesis and Catalytic Reactions
- Synthesis of heterocyclic compounds
- Catalytic C–H Functionalization Methods
Seoul National University
2023-2024
Penn State Milton S. Hershey Medical Center
2019
Pennsylvania State University
2019
<h3>Importance</h3> Although a few studies have shown that mental health disorders (MHDs) are strongly associated with the 5-year survival and recurrence rates in patients head neck cancer (HNC), none been replicated large-scale study. <h3>Objective</h3> To describe prevalence of MHDs HNC potential associations using large insurance claims database. <h3>Design, Setting, Participants</h3> This retrospective cohort study assessed data queried from MarketScan database January 1, 2005, through...
Substituted pyridines with diverse functional groups are important structural motifs found in numerous bioactive molecules. Several methodologies for the introduction of various bio-relevant to pyridine have been reported, but there is still a need single robust method allowing selective multiple groups. This study reports ring cleavage methodology reaction synthesis 2-alkyl/aryl 3-electron-withdrawing (esters, sulfones, and phosphonates) 5-aminoaryl/phenol via remodeling 3-formyl...
Abstract Objective The main purpose of this article is to examine the prevalence, incidence, sociodemographic, and clinical characteristics mental health disorders (MHDs) among patients with skull base malignancies. Design Retrospective cohort study. Settings/Participants Six-thousand seven-hundred sixty sinonasal/skull cancer in MarketScan database between 2005 2014. Main Outcome Measures Frequency MHDs pre- post-diagnosis harboring Results A significant increase was noted from post-cancer...
Abstract Pyridine, an essential structure in drug development, shows a wide array of bioactivities according to its substitution patterns. Among the bioactive pyridines, meta -substituted pyridines suffer from limited synthetic approaches despite their significance. In this study, we present novel method enabling facile incorporation biologically relevant functional groups at position pyridine. This methodology unveiled concealed reactivity 3-formyl(aza)indoles as diformylmethane analogs for...
Abstract Pyridine, an essential structure in drug development, shows a wide array of bioactivities according to its substitution patterns. Among the bioactive pyridines, meta -substituted pyridines suffer from limited synthetic approaches despite their significance. In this study, we present condensation-based method enabling facile incorporation biologically relevant functional groups at position pyridine. This methodology unveiled concealed reactivity 3-formyl(aza)indoles as...
Abstract The ongoing global threats posed by COVID‐19 pandemic, catalyzed SARS‐CoV‐2, underscores the pressing need for effective antiviral strategies. viral non‐structural protein 1 (Nsp1) significantly influences pathogenicity impeding host expression and enhancing RNA translation through its interaction with stem‐loop (SL1) in 5′ untranslated region (UTR). We have developed a novel dual‐luciferase reporter assay, designed to investigate critical Nsp1–SL1 interaction, identified P23E02 as...
Abstract The ongoing global threats posed by COVID‐19 pandemic, catalyzed SARS‐CoV‐2, underscores the pressing need for effective antiviral strategies. viral non‐structural protein 1 (Nsp1) significantly influences pathogenicity impeding host expression and enhancing RNA translation through its interaction with stem‐loop (SL1) in 5′ untranslated region (UTR). We have developed a novel dual‐luciferase reporter assay, designed to investigate critical Nsp1–SL1 interaction, identified P23E02 as...