A5069584767- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Colorectal Cancer Surgical Treatments
- Diverticular Disease and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Anorectal Disease Treatments and Outcomes
- Cancer Treatment and Pharmacology
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- Cancer Research and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Esophageal and GI Pathology
- Enhanced Recovery After Surgery
- Neuroendocrine Tumor Research Advances
- Multiple and Secondary Primary Cancers
- Sarcoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Intraperitoneal and Appendiceal Malignancies
- Intestinal Malrotation and Obstruction Disorders
- Nausea and vomiting management
- Stoma care and complications
Nippon Medical School
2016-2025
Musashino University
2024
Nagasaki University Hospital
2023-2024
Nippon Medical School Hospital
2016-2023
Sapporo Kosei General Hospital
2013-2014
Osaka City General Hospital
2012
National Jewish Health
2006
University of Colorado Denver
2006
Abstract A significant association exists between the gut microbiome and colorectal carcinogenesis, as well cancer progression. It has been reported that Escherichia coli ( E. ) containing polyketide synthetase pks island contribute to carcinogenesis by producing colibactin, a polyketide‐peptide genotoxin. However, functions of + in initiation, proliferation, metastasis (CRC) remain unclear. We investigated clinical significance clarify its CRC. This study included 413 patients with Pks...
Liquid biopsy using circulating tumor DNA (ctDNA) is useful for precision medicine and molecular-guided oncology; however, its sensitivity insufficient. We focused on in extracellular vesicles (evDNA) as a new target liquid investigated sensitivity. This observational study included 334 Stage I-IV colorectal cancer patients. evDNAs ctDNAs were extracted from plasma collected before surgery. KRAS mutation status was analyzed droplet digital PCR. One hundred forty-eight patients had mutations...
We recruited 56 colorectal cancer patients and compared the mutational spectrum of tumor tissue DNA, circulating cell-free DNA (ccfDNA) cell (CTC) (ctcDNA) to evaluate potential liquid biopsy detect heterogeneity cancer. Tumor ccfDNA, ctcDNA were extracted from each patient analyzed using next-generation sequencing (NGS) digital PCR. To maximize yields CTC, three antibodies used in capture process. From 34 untreated patients, 53 mutations detected NGS. Forty-seven including 20 not tissues....
Anastomotic leakage (AL) is the most serious and common complication of surgery for rectal cancer, associated risk factors remain unknown despite developments in laparoscopic surgery. The present study aimed to determine AL after anterior resection (AR) cancer.This retrospective cohort extracted information from a prospective database all consecutive colorectal resections that proceeded at Nippon Medical School Hospital between January 2011 December 2015 (n = 865). We identified 154 patients...
The combination of oxaliplatin, leucovorin and fluorouracil (FOLFOX) has been established as postoperative adjuvant chemotherapy for stage III colon cancer. However, the safety efficacy neoadjuvant FOLFOX in patients with rectal cancer are still controversial. This prospective pilot study aimed to evaluate feasibility therapy without radiation baseline resectable (RC).The included 30 clinical II/III RC between February 2012 December 2015. were treated six cycles followed by elective surgery....
Background and Objectives Oxaliplatin can cause hepatic sinusoidal obstruction syndrome (SOS). SOS chemotherapy‐related adverse effects or morbidity after liver resection. Conventionally, is diagnosed using biopsy. Recently, it was reported that increased splenic volume (SV) be used to detect SOS. In this study, we evaluated the changes in SV during adjuvant chemotherapy. Methods We enrolled 103 consecutive patients with stage III high‐risk II colorectal cancer treated mFOLFOX6 ( n = 37)...
Dedifferentiated liposarcoma of the mesentery is an extremely rare tumor. A 71-year-old man with a 2-month history abdominal distention was admitted to our department for evaluation and treatment mass. Computed tomography magnetic resonance imaging revealed 11 × 9 cm mass lesion fat density in upper right cavity, displacing ascending transverse colon ventrally. Abdominal angiography showed small feeding vessels tumor from ileocolic artery middle colic artery. On basis these findings, arising...
Mucoceles of the appendix are a group mucus-filled lesions causing obstructive dilation ileocecal appendix. We report rare case giant appendiceal mucocele. A 48-year-old woman, with no discomfort, was admitted to our hospital after mass detected in right lower quadrant abdomen. The patient underwent hemicolectomy on basis clinical diagnosis possible tumor. final pathologic mucocele
Diagnostic markers for recurrence of colorectal cancer have not been established. The aim the present study was to identify new diagnostic after curative surgery stage II colon cancer.In this study, prognostic values preoperative lymphocyte count and post/preoperative ratio (PPLR) were evaluated in 142 patients with localized treated at a single medical center. associations patient demographics, blood chemistry, serum biochemical indices recurrence-free survival (RFS) cancer-specific (CSS)...
Abstract The incidence of rare neuroendocrine tumors (NET) is rapidly increasing. Neuroendocrine carcinoma (NEC) a NET with poorly differentiated histological features, high proliferative properties and associated poor prognoses. As these carcinomas are so and, thus, affect only small number patients allowing for few cell lines to be derived from patient biopsies, the histological, immunohistochemical, clinical characteristics colorectal NEC in other organs have yet clearly defined. Herein,...