A5064948201- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Liver Disease and Transplantation
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Gallbladder and Bile Duct Disorders
- Inflammatory Biomarkers in Disease Prognosis
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Research and Treatments
- Abdominal Trauma and Injuries
- Pancreatitis Pathology and Treatment
- Genetic factors in colorectal cancer
- Liver Disease Diagnosis and Treatment
- Abdominal vascular conditions and treatments
- Ultrasound in Clinical Applications
- Pelvic and Acetabular Injuries
- Drug Transport and Resistance Mechanisms
- Cancer, Lipids, and Metabolism
- Hernia repair and management
- Congenital Heart Disease Studies
- Intestinal Malrotation and Obstruction Disorders
- Appendicitis Diagnosis and Management
Nippon Medical School
2015-2024
Nippon Medical School Hospital
2016-2018
Small bowel adenocarcinomas (SBAs) are rare and there is little comprehensive data on SBA genomic alterations for Asian patients. This study aimed to profile of in Japanese patients using targeted next-generation sequencing (NGS).We examined 22 surgical resections from with primary SBA. were analyzed by NGS. Mismatch repair (MMR) status was determined immunohistochemical analysis. Mucin phenotypes classified as gastric (G), intestinal (I), gastrointestinal (GI), null (N) types MUC2, MUC5AC,...
Objective The spleen is part of the lymphatic system and one least understood organs human body. It involved in production blood cells helps filter blood, remove old cells, fight infection. Partial splenic artery embolization (PSE) widely used to treat pancytopenia portal hypertension. efficacy PSE for improving thrombocytopenia has been well demonstrated. In this study, we evaluated infarction ratio platelet increase after PSE. Methods Forty-five consecutive patients underwent from January...
Relatively high mortality and morbidity rates are reported after liver resection (LR). However, the early predictors of complications LR not clear. This study was performed to clarify usefulness procalcitonin (PCT) for prediction elective LR.This observational included 72 consecutive patients who underwent from December 2015 March 2017. Patients were categorized into two groups: those with without postoperative (Clavien-Dindo grade ≥II). The values inflammatory markers (white blood cell...
Cecal volvulus is characterized by torsion of the cecum around its own mesentery. However, cecal rarely develops soon after elective laparoscopic cholecystectomy. We report on a case that developed in 54-year-old women 1 day cholecystectomy and was successfully treated via colonoscopic decompression. The symptoms gradually improved conjunction with recovery from postoperative ileus. Whether incidence has increased use procedures, including cholecystectomy, yet to be determined. Considering...
Acute portal vein thrombosis (PVT) with bowel necrosis is a fatal condition 50%-75% mortality rate. This report describes the successful endovascular treatment (EVT) of two patients severe PVT.The first patient was 22-year-old man who presented abdominal pain lasting 3 d. The second 48-year-old acute pain. Following contrast-enhanced computed tomography, both were diagnosed massive PVT extending to splenic and superior mesenteric veins. Hybrid (simultaneous necrotic resection EVT) performed...
Abstract Background In Japan, primary hepatocellular carcinoma (HCC) often develops against a background of chronic hepatitis, such as persistent hepatitis B virus (HBV) or C (HCV) infection. Patients with HCC are commonly in their 50s 60s. It is extremely rare to find patients 40s younger. cases reported constitute only 0.23% all cases. The adolescent and young adult (AYA) population refers people aged 15–39 years. cancer the AYA may present special clinical features biologic...
Resectability of hepatic metastases which have developed from lung cancer is limited and only a few reports been published. We report two cases surgical resection liver arising cancer. A 77-year-old male underwent lower left lobectomy to treat primary large cell carcinoma. Eight months later, abdominal computed tomography revealed slightly enhanced heterogeneous tumor measuring 50 mm in diameter the right liver, segment 8. performed anterior sectionectomy. The pathological findings were...
With the advent of effective chemotherapy, conversion surgery (CS) has been performed in patients who have responded to pretreatment, even for pancreatic cancer diagnosed as unresectable (UR) at time initial diagnosis. In CS, major arterial resection and reconstruction are necessary complete radical resection.
Pancreatic body and tail cancer easily invades retroperitoneal tissue, including the transverse mesocolon. It is difficult to ensure a dissected peripancreatic margin with standard distal pancreatectomy for advanced pancreatic cancer. Thus, we developed novel surgical procedure dissection of margin. This involved performing deeper than fusion fascia Toldt further extensive en bloc resection root We performed mesocolon (DP-TCR) using mesenteric approach achieved good outcomes.There are two...
Laparoscopic incisional hernia repair with mesh is widely performed in Western countries as a treatment that considered more reliable than conventional open repair. However, this procedure not common Japan. We report our experiences using new type of (Ventralight ST TM, Medicon, Osaka, Japan). This indicated for almost all patients but was difficult to perform giant the flank after nephrectomy. The patient supine position and 4 or 5 ports. One port 12-mm port, others are 5-mm First, inserted...
左上大静脈遺残に右上大静脈欠損を合併した食道癌に切除術を行った報告例は非常に少ない．症例は72歳，男性．食欲不振を主訴に近医を受診し，食道扁平上皮癌を指摘され当科紹介となった．既往歴は，連合弁膜症（大動脈弁閉鎖不全症，僧帽弁閉鎖不全症）であった．3D-CT検査で左上大静脈遺残，右上大静脈欠損が判明した．腹臥位胸腔鏡下食道切除，腹腔鏡補助下胃管作製，後縦隔経路で食道再建術を施行した．胸腔鏡所見で，右上大静脈欠損，無名静脈，通常より極めて細い奇静脈弓を認めた．術中の循環動態は安定していた．術後合併症はなかった．食道癌手術を安全に施行するために，術前に大血管異常を診断することは重要であると思われた．
Introduction: Oncogenic KRAS mutations are negative biomarkers of response to epidermal growth factor receptor (EGFR) blockade. mutation is usually detected in biopsies primary colorectal tumors. However, the genomic profiles tumors and metastases not always concordant, chemotherapeutic agents targeted drugs can alter tumor molecular landscape. Circulating DNA (ctDNA) a novel tool detect heterogeneity. In this study, we tried clarify mechanism or secondary resistance EGFR blockade as...
症例は38歳，女性．嚥下困難を主訴に近医を受診．食道粘膜下腫瘍を指摘され当科紹介となった．上部消化管内視鏡検査では頸胸部食道に隆起性粘膜下病変を認め，生検の病理組織所見で核異型・分裂像著明な紡錘形細胞が錯綜状に配列し，Ki-67染色は高度陽性であった．食道原発平滑筋肉腫の疑いにて，胸腔鏡手技を併用した喉頭温存食道全摘術を施行し，後縦隔経路で挙上した胃管・有茎遊離空腸・咽頭の再建術を施行した．切除標本の免疫組織染色では，desmin・α-SMAが陽性，c-kit・CD34・S-100蛋白・keratinは陰性であり，平滑筋肉腫と診断した．術後の嚥下機能は良好であった．術後半年以上経過するも再発徴候は認めていない．頸胸部食道平滑筋肉腫に対して，胸腔鏡下手術を併用し根治性を担保でき，さらに頭頸部外科・形成外科との合同手術で喉頭機能を温存することができた症例を経験したので報告する．
Endoscopic retrograde cholangiopancreatography (ERCP) is essential for diagnosing and treating biliopancreatic disease. Because ERCP-related perforation can result in death, therapeutic decisions are important. The aim of this study was to determine the cause suggest appropriate management.Between January 1999 August 2022, 7,896 ERCPs were performed our hospital. We experienced 15 cases (0.18%) conducted a retrospective review.Of patients, 6 female 9 male, mean age 77.1 years. According...
The spleen is a lymphatic organ that manages immune surveillance of the blood, produces blood cells, and helps filter remove old fight infection. normal splenic weight approximately 65-265 g. This study evaluated volume segmental volume.
547 Background: Epidermal growth factor receptor (EGFR) blockade can achieve considerable tumor shrinkage in patients with metastatic colorectal cancer (CRC). However, most who benefit from EGFR acquire resistance within a year through emerging KRAS, BRAF or ( S492R) mutations. We have shown that KRAS mutations circulating cell-free DNA (ccfDNA) do not respond favorably to blockade. In this study, we aimed detect acquired early by using ccfDNA track and S492R during chemotherapy. Methods:...
Abstract Background: Decompression using selfexpandable metallic stent (SEMS) has been reported to improve short-term outcomes in patients with malignant large bowel obstruction (MLBO). However, some reports suggest that SEMS worsen long-term survival. Conversely, trans-anal drainage tubes (TDT), which are similar the ileus widely used Japan for MLBO, have had no suggesting reduced survival by compressing tumor continuously and induce cell death can lead production of various types mediator...
Abstract [Background] It is well known that emerging mutations which not found in the primary tumor exist metastatic and molecular therapy induce mutation. Liquid biopsy, includes circulating cell (CTC) DNA (ctDNA), may help detecting this spatial temporal heterogeneity. We have reported KRAS mutation can be detected by using ctDNA (Yamada et al, Cancer Science 2016). However, detection CTC has been difficult because enough amount of cannot extracted from CTC. Currently we able to collect...