A5069105951- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Metastasis and carcinoma case studies
- Abdominal Trauma and Injuries
- Gastrointestinal Tumor Research and Treatment
- Neuroendocrine Tumor Research Advances
- Organ Transplantation Techniques and Outcomes
- Renal cell carcinoma treatment
- Oral and Maxillofacial Pathology
- Endoplasmic Reticulum Stress and Disease
- Diverticular Disease and Complications
- Gastrointestinal disorders and treatments
- Head and Neck Cancer Studies
- Renal and related cancers
- Pediatric Hepatobiliary Diseases and Treatments
- Ion Transport and Channel Regulation
- Cancer Research and Treatments
- Biliary and Gastrointestinal Fistulas
- Cancer Diagnosis and Treatment
- Abdominal vascular conditions and treatments
- Retinal and Optic Conditions
Nippon Medical School
2015-2024
Nippon Medical School Musashi Kosugi Hospital
2023-2024
Chiba Hokusou Hospital
2012-2020
Nippon Medical School Hospital
2017
Sapporo Kosei General Hospital
2014
Tohoku Medical and Pharmaceutical University
1989-1990
Kyushu Dental University
1986-1989
Protein disulfide‑isomerase A3 (PDIA3) is a chaperone protein that modulates folding of newly synthesized glycoproteins and responds to endoplasmic reticulum (ER) stress. Previous studies reported increased expression PDIA3 in hepatocellular carcinoma (HCC) marker for poor prognosis. However, the mechanism remains poorly understood. The aim present study, therefore, was understand role HCC development. First, immunohistochemical staining tissues from 53 cases revealed with high exhibited...
Colorectal cancer (CRC) is one of the most common cancers worldwide, and many patients are already at an advanced stage when they diagnosed. Therefore, novel biomarkers for early detection colorectal required. In this study, we performed a global shotgun proteomic analysis using formalin-fixed paraffin-embedded (FFPE) CRC tissue. We identified 84 candidate proteins whose expression levels were differentially expressed in non-cancer regions. A label-free semiquantitative method based on...
The prognosis of hepatocellular carcinoma (HCC) is unfavorable following complete tumor resection. aim the present study was to identify a molecule able predict HCC through comprehensive protein profiling and elucidate its clinicopathological significance. Comprehensive performed by liquid chromatography-tandem mass spectrometry. Through bioinformatic analysis proteins expressed differentially in non-HCC tissues, disulfide-isomerase A3 (PDIA3) identified as candidate for prediction...
Simple hepatic cysts are typically saccular, thin-walled masses with fluid-filled epithelial lined cavities. They arise from aberrant bile duct cells that develop during embryonic development. With the development of diagnostic modalities such as ultrasonography (US), CT, and MRI, simple frequently detected in clinical examinations. US is most useful noninvasive tool for diagnosis can usually differentiate abscesses, hemangiomas, malignancies. Cysts irregular walls, septations,...
We present the case of a rapidly growing inferior vena cava tumor thrombus in renal cell carcinoma.
Objective The spleen is part of the lymphatic system and one least understood organs human body. It involved in production blood cells helps filter blood, remove old cells, fight infection. Partial splenic artery embolization (PSE) widely used to treat pancytopenia portal hypertension. efficacy PSE for improving thrombocytopenia has been well demonstrated. In this study, we evaluated infarction ratio platelet increase after PSE. Methods Forty-five consecutive patients underwent from January...
Introduction. Leiomyosarcomas of vascular origin are particularly rare tumors occurring mainly in the inferior vena cava (IVC). They malignant, slow-growing with a poor prognosis. This paper reports on case surgical resection an IVC leiomyosarcoma mimicking hepatic tumor. Case Presentation. A 65-year-old Japanese male was admitted for evaluation abdominal Enhanced computed tomography abdomen revealed slightly enhanced heterogeneous tumor, 18 mm diameter, between Spiegel lobe liver and...
Recently, some reports have revealed a relationship between post-hepatectomy prognosis in hepatocellular carcinoma (HCC) and hepatic fibrosis markers. We evaluated the these markers of fibrosis, clinicopathological findings, prognosis.Three hundred sixty patients underwent hepatectomy for HCC Nippon Medical School Hospital 1993 2013. divided into two groups: normal serum hyaluronic acid (HA) levels abnormal levels. also groups with type IV collagen levels.The overall survival rate...
Gallstone ileus is a rare complication of cholecystolithiasis, with the majority cases requiring surgical treatment. In this paper, we describe case gallstone that was successfully treated twice conservative therapy. An 85-year-old woman admitted to our hospital because abdominal pain and vomiting. She had previously been antibiotics for cholecystitis arising from 2 gallbladder stones. Computed tomography (CT) revealed small bowel dilated 1 stones disappeared. addition, 28×22-mm calcified...
mTOR is involved in the proliferation of liver cancer. However, clinical benefit treatment with inhibitors for cancer controversial. Protein disulfide isomerase A member 3 (PDIA3) a chaperone protein, and it supports assembly complex 1 (mTORC1) stabilizes signaling. Inhibition PDIA3 function by small molecule known as 16F16 may destabilize mTORC1 enhance effect inhibitor everolimus (Ev). The aim present study was to elucidate usefulness combination Ev using cultured Li-7 HuH-6 cells. cells...
We report a case of advanced stomach cancer metastatic to the spermatic cord 1 year after curative distal gastrectomy. The patient underwent gastrectomy with D2 lymph node dissection. There was no metastasis liver or peritoneum, and cytologic examination peritoneal lavage fluid negative for cells (CY0). Histological revealed moderately differentiated tubular adenocarcinoma that had penetrated serosa (T4a). Postoperative staging T4aN1M0, stage IIIA, according Japanese gastric carcinoma...
Although hepatic hemangiomas are common, gallbladder (GB) extremely rare. We present a case of cavernous GB hemangioma, which was detected during routine ultrasonography screening. The 51-year-old female patient asymptomatic and had no relevant medical history. preoperative imaging findings, including those endoscopic ultrasonography, suggested that malignancy highly unlikely in this submucosal tumor. Thus, we performed single-incision laparoscopic cholecystectomy as diagnostic curative...
We report a case of metastatic pancreatic-head mucinous carcinoma (with multiple lymph node and bone metastases) review the relevant literature. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) was useful for diagnosis, satisfactory outcome achieved after systemic chemotherapy with FOLFIRINOX followed by resection primary lesion as conversion surgery. The patient 55-year-old man. Hematological findings included elevated serum tumor marker levels: CEA 12.7 ng/mL, DUPAN-2 400...
Cystic echinococcosis (CE) is a rare afferent infectious disease in Japan. This paper reports case of hepatic cyst being diagnosed after surgical resection. A 40-year-old Syrian male was admitted for evaluation cyst. Serum antibodies were negative. Enhanced computed tomography the abdomen revealed large cystic lesion, 9 cm diameter, left lateral sector liver, which had many honeycomb-like septa and calcified lesions. Magnetic resonance imaging this lesion high intensity T2 weighted image. We...
At present the only method available to confirm microscopic infiltration of cancer into ductal margins during surgery, is intraoperative histological examination. In study, status surgical and postoperative course were evaluated determine any correlation between remnant carcinoma survival. All consecutive patients who underwent resection for biliary tract January 2004 May 2012 identified from a database. Positive margin cases divided two groups, invasive in situ (CIS). Immunohistochemical...
症例は71歳,男性.近医で施行された腹部超音波検査にて肝S7に径50 mm大の腫瘍を指摘され,当院紹介となった.腫瘍マーカーはAFP,PIVKA-IIが高値であり,腹部CT,MRI,経動脈性血管造影CTで肝S7,S3に腫瘤を認めた.肝S3の腫瘤の造影効果は典型的ではなかったが,腫瘍マーカーの上昇およびB型肝炎ウイルスの既往感染の背景を考慮し,多発肝細胞癌と診断.肝S7亜区域切除術+肝S3部分切除術を施行した.病理組織学的検査で肝S7の腫瘍は数層からなる索状構造を形成しており,中分化型肝細胞癌と診断した.肝S3の腫瘍は,肝内胆管癌と細胆管細胞癌が混在しており,細胆管細胞癌成分を伴った肝内胆管癌と診断した.胆管癌であり部分切除では不十分と判断し,肝外側区域切除術およびリンパ節郭清を追加施行した.肝細胞癌と細胆管細胞癌成分を伴った肝内胆管癌の同時性重複癌の切除報告例は少なく,稀少性からも貴重な症例と思われたので,文献的考察を加え報告する.