A5010145256- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- Metastasis and carcinoma case studies
- Cancer Treatment and Pharmacology
- Colorectal and Anal Carcinomas
- Cancer Genomics and Diagnostics
- Gastrointestinal Tumor Research and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Intestinal and Peritoneal Adhesions
- Diverticular Disease and Complications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hernia repair and management
- Gastrointestinal disorders and treatments
- Inflammatory Biomarkers in Disease Prognosis
- Sarcoma Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Hepatocellular Carcinoma Treatment and Prognosis
- Multiple and Secondary Primary Cancers
- Sepsis Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Infectious Aortic and Vascular Conditions
Nippon Medical School
2020-2025
Shiga University of Medical Science
2014-2024
Showa General Hospital
2024
Kyushu University
2003-2024
Fujita Health University
2022
Nippon Medical School Hospital
2021
Kyoto first Red Cross hospital
2010-2015
National Kyushu Medical Center
2012
Matsuyama Red Cross Hospital
2006
National Cerebral and Cardiovascular Center
2003-2004
Abstract A significant association exists between the gut microbiome and colorectal carcinogenesis, as well cancer progression. It has been reported that Escherichia coli ( E. ) containing polyketide synthetase pks island contribute to carcinogenesis by producing colibactin, a polyketide‐peptide genotoxin. However, functions of + in initiation, proliferation, metastasis (CRC) remain unclear. We investigated clinical significance clarify its CRC. This study included 413 patients with Pks...
There are no standardised criteria for the 'regional' pericolic node in colon cancer, which represents a major cause of international uncertainty regarding optimal bowel resection margin. This study aimed to determine nodes based on prospective lymph (LN) mapping.According preplanned vivo measurements bowel, anatomical distributions feeding artery and LNs were determined 2996 stages I-III cancer patients who underwent colectomy with margin >10 cm at 25 institutions Japan.The mean number...
Background/Aim: To explore the survival benefit of adjuvant chemotherapy for obstructive colorectal cancer (OCRC) managed by self-expandable metallic stent (SEMS) placement as a bridge to surgery (BTS). Patients and Methods: One hundred twenty-nine patients with pathological stage II/III OCRC who underwent BTS using SEMS were included in this multicenter retrospective study. divided into no-adjuvant group (No-Adj group) (n=52) (Adj (n=77), relapse-free (RFS) was compared. Results: The No-Adj...
ABSTRACT For patients with resectable colorectal liver metastases (CRLM), the efficacy of adjuvant chemotherapy remains a subject debate. Several studies have concluded that postoperative circulating tumor DNA (ctDNA) is marker minimal residual disease (MRD) and useful prognostic factor in nonmetastatic cancer. However, few explored its application cases involving metastases. This was an observational study included CRLM who underwent primary resection. By examining targeted sequencing 50...
Initially, unresectable locally advanced colorectal cancers are still not uncommon. Despite recently developed systemic treatment has extended the survival of patients with and recurrent disease, surgical resection offers chance for a cure or long-term survival. Recently, improvement in safety major vascular reconstruction, several reports have suggested that pelvic tumor reconstruction curative intent can be performed safely; however, indications arterial remain controversial reported...
Liquid biopsy using circulating tumor DNA (ctDNA) is useful for precision medicine and molecular-guided oncology; however, its sensitivity insufficient. We focused on in extracellular vesicles (evDNA) as a new target liquid investigated sensitivity. This observational study included 334 Stage I-IV colorectal cancer patients. evDNAs ctDNAs were extracted from plasma collected before surgery. KRAS mutation status was analyzed droplet digital PCR. One hundred forty-eight patients had mutations...
Irinotecan is a key drug for patients with advanced and recurrent colorectal carcinoma. However, the efficacy of irinotecan not sufficient; partly, as there no useful marker to predict chemosensitivity drug. The aim present study was evaluate whether expression levels adenosine triphosphate-binding cassette sub-family G (WHITE) member 2 (Junior blood group) (ABCG2) in primary tumors chemoresistance irinotecan. Using resected tumor specimens 189 cancer, association between immunohistochemical...
// Daiji Ikuta 1 , Toru Miyake Tomoharu Shimizu Hiromichi Sonoda Ken-Ichi Mukaisho 2 Aya Tokuda Tomoyuki Ueki Hiroyuki Sugihara and Masaji Tani Department of Surgery, Shiga University Medical Science, Shiga, Japan Molecular diagnostic Pathology, Correspondence to: Miyake, email: myk@belle.shiga-med.ac.jp Keywords: cancer-associated fibroblast; colorectal cancer; fibroblastic reticular cell; fibrosis; lymph node metastasis Received: December 23, 2017 Accepted: June 03, 2018 Published: July...
To identify new cancer biomarkers and therapeutic targets for colorectal cancers (CRCs), we performed immunohistochemical analysis using tissue microarrays covering archival tumor samples from 434 CRC patients antibodies to cell division cycle-associated protein 1 (CDCA1) that was originally identified as an oncoantigen by our gene expression profile database, compared its with several clinicopathological factors. Strong CDCA1 positivity associated poorer prognosis (P=0.019) multivariate...
Abstract Totally implantable access ports (TIAPs) are generally used in oncology. Few studies have addressed complications associated with the insertion site. A total of 233 consecutive oncology patients were enrolled to receive TIAP inserts via internal jugular vein (IJV) or subclavian (SV). Data on clinicopathologic parameters and early/late retrospectively collected. No differences found early late complication rates. Catheter injury was observed more frequently IJV group (2.9%) than SV...
Background/Aim: Our multicenter phase II TAS-CC3 study demonstrated favorable median progression-free survival (PFS) and overall (OS) of 32 metastatic colorectal cancer (mCRC) patients treated with TAS-102 + bevacizumab as 3<sup>rd</sup>-line treatment. Patients Methods: We investigated the predictive prognostic values pre-treatment blood inflammation-based scores, including neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR) lymphocyte-to-monocyte ratio (LMR) on disease-control...
Abstract In order to reduce the compliance mismatch between native artery and artificial graft, we have developed a coaxial double‐tubular compliant using multiply micropored segmented polyurethane (SPU) thin films, which mimics relationship intraluminal pressure vessel internal diameter (P‐D) of (termed “J” curve). The graft was coaxially assembled by inserting high‐compliance inner tube with heparin‐immobilized photocured gelatin coating layer into low‐compliance outer hydrophilic polymer...