A5074473123- Immune Cell Function and Interaction
- Dermatology and Skin Diseases
- Platelet Disorders and Treatments
- CAR-T cell therapy research
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Psoriasis: Treatment and Pathogenesis
- Immunotherapy and Immune Responses
- Asthma and respiratory diseases
- Histone Deacetylase Inhibitors Research
- T-cell and B-cell Immunology
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Cytomegalovirus and herpesvirus research
- Mesenchymal stem cell research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Response and Inflammation
Universidad de Valladolid
2018-2022
Instituto de Biomedicina y Genética Molecular de Valladolid
2018-2022
Instituto de Investigación Biomédica de Salamanca
2015
Complejo Hospitalario de Salamanca
2012
Centro de Investigación del Cáncer
2009
In vitro depletion of alloreactive T cells using the proteasome inhibitor bortezomib is a promising approach to prevent graft-versus-host disease after allogeneic stem cell transplantation. We have previously described ability selectively eliminate in mixed leukocyte culture, preserving non-activated cells. Due role regulatory control graft versus host disease, current manuscript we analyzed effect cells.Conventional or CD4(+) were isolated with immunomagnetic microbeads based on expression...
Increased glycolysis parallels immune cell activation, but the role of pyruvate remains largely unexplored. We found that stimulation dendritic cells with fungal surrogate zymosan causes decreases pyruvate, citrate, itaconate, and α-ketoglutarate, while increasing oxaloacetate, succinate, lactate, oxygen consumption, dehydrogenase activity. Expression IL10 IL23A (the gene encoding p19 chain IL-23) depended on Mechanistically, reinforced histone H3 acetylation, acetate rescued effect...
Abstract Cytokine expression is fine-tuned by metabolic intermediates, which makes research on immunometabolism suitable to yield drugs with a wider prospect of application than the biological therapies that block proinflammatory cytokines. Switch from oxidative phosphorylation (OXPHOS) glycolysis has been considered characteristic feature activated immune cells. However, some stimuli might enhance both routes concomitantly. The connection between tricarboxylic acid cycle and cytokine was...
Increased glycolysis parallels immune cell activation, but the role of pyruvate flux remains largely unexplored. We show that stimulation dendritic cells with fungal surrogate zymosan induces a drop pyruvate, citrate, itaconate, and α-ketoglutarate, as well an increase in oxaloacetate, succinate, lactate, oxygen consumption, activation dehydrogenase activity. The expression IL10 IL23A (the gene encoding p19 chain IL-23) depended on mitochondrial Pyruvate underpinned histone H3 acetylation...