A5000390829- Field-Flow Fractionation Techniques
- Chemical Thermodynamics and Molecular Structure
- Nuclear reactor physics and engineering
- Conducting polymers and applications
- Acute Myeloid Leukemia Research
- Microfluidic and Bio-sensing Technologies
- Magnetic and Electromagnetic Effects
- Advanced Thermodynamics and Statistical Mechanics
- Social Sciences and Policies
- thermodynamics and calorimetric analyses
- Advanced Sensor and Energy Harvesting Materials
- Microbial Inactivation Methods
- Electrochemical Analysis and Applications
- Music Technology and Sound Studies
- Electrochemical sensors and biosensors
- Phase Equilibria and Thermodynamics
- Analytical Chemistry and Sensors
- Structural Health Monitoring Techniques
- Chronic Lymphocytic Leukemia Research
- Mesenchymal stem cell research
- Epigenetics and DNA Methylation
- Chemical and Physical Properties in Aqueous Solutions
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Retinoids in leukemia and cellular processes
Hospital Universitario de La Princesa
2023
Hospital Nacional de Niños
2018-2021
Oncotherapeutics (United States)
2021
University of the Basque Country
2007-2019
Hudson Institute
2019
John Wiley & Sons (United States)
2019
Universidad de Salamanca
1984-2012
Complejo Hospitalario de Salamanca
2007-2012
Mondragon University
2007-2012
Centro de Investigación del Cáncer
2008-2012
In Brief Study Design. To identify mesenchymal stromal cells (MSC) from degenerate human nucleus pulposus (NP) and compare them with bone marrow (BM) MSC. Objective. test whether MSC obtained NP BM the same subjects share similar biologic characteristics. Summary of Background Data. Recent studies have proposed strategies for treatment intervertebral disc degeneration, including cell therapy. Bone could be an attractive approach to restore function, there is evidence that may contain...
Background Recent findings suggest that a specific deletion of Dicer1 in mesenchymal stromal cell-derived osteoprogenitors triggers several features myelodysplastic syndrome murine model. Our aim was to analyze DICER1 and DROSHA gene protein expression cells (the osteoblastic progenitors) obtained from bone marrow patients, addition microRNA profile other target genes such as SBDS, DICER1-related promotes dysfunction myelodysplasia when repressed model.Design Methods Mesenchymal 33 samples...
In this study, we have measured the thermodiffusion coefficients of six hydrocarbon liquid ternary mixtures at 25 °C using thermogravitational technique. Mixtures 1,2,3,4-tetrahydronaphthalene-isobutylbenzene-n-dodecane four different concentrations and 1,2,3,4-tetrahydronaphthalene-isobutylbenzene-n-decane two been considered. We used a plane-thermogravitational column with small gap dimension to improve accuracy recently reported data. The obtained results confirmed by measurements in...
Background and Objectives The detection of PML-RARα by real-time polymerase chain reaction (RQ-PCR) is becoming an important tool for monitoring minimal residual disease (MRD) in patients with acute promyelocytic leukemia (APL). However, its clinical value remains to be determined. Our aim was analyze any associations between the risk relapse RQ-PCR results different phases treatment, comparing these data those yielded conventional qualitative reverse transcriptase-PCR.Design Methods...
Background Bone loss, in malignant or non-malignant diseases, is caused by increased osteoclast resorption and/or reduced osteoblast bone formation, and commonly associated with skeletal complications. Thus, there a need to identify new agents capable of influencing remodeling. We aimed further pre-clinically evaluate the effects dasatinib (BMS-354825), multitargeted tyrosine kinase inhibitor, on differentiation function. Methods For studies osteoblasts, primary human marrow mensenchymal...
A rapid measurement of the components R and XL AT-cut quartz crystal electroacoustic impedance at 10 MHz is reported. Parametric plane plots (XLvs. R) are introduced to analyse effect mass/volume viscoelastic changes in films liquids contact with during dynamic chemical or electrochemical processes. Experimentaldata for selected systems, liquids, self-assembledlayers electroactive polymers, presented. These results discussedon basis model Granstaff Martin describe real andimaginary...
In vitro depletion of alloreactive T cells using the proteasome inhibitor bortezomib is a promising approach to prevent graft-versus-host disease after allogeneic stem cell transplantation. We have previously described ability selectively eliminate in mixed leukocyte culture, preserving non-activated cells. Due role regulatory control graft versus host disease, current manuscript we analyzed effect cells.Conventional or CD4(+) were isolated with immunomagnetic microbeads based on expression...
In this work we have measured the molecular diffusion coefficient of n-alkane binary series nC(i)-nC(6), nC(i)-nC(10), and nC(i)-nC(12) at 298 K 1 atm a mass fraction 0.5 by using so-called sliding symmetric tubes technique. The results show that concentration is proportional to inverse viscosity mixture. addition, also systems nC(12)-nC(6), nC(12)-nC(7), nC(12)-nC(8) as function concentration. From data obtained, it shown mixtures any can be calculated from weight components dynamic...
We have designed and constructed a thermogravitational column for determining the Soret coefficient of liquid mixtures. The excellent agreement results obtained toluene n-hexane mixtures with recent accurate measurements performed by optical methods shows validity method when correct geometry is used. applied this technique to determine binary systems benzene-n-heptane carbon tetrachloride cyclohexane, methanol ethanol. Comparison literature data allows us reliability existing thermal diffusion these
Experimental data on ordinary diffusion coefficients and thermal factors for binary liquid systems containing hexane, heptane, benzene, toluene carbon tetrachloride are derived from steady-state non-steady-state separation measurements in a column. The extraction method uses time evolution theory previously developed by the authors that accounts forgotten effect. Comparison of with those literature provides test factors.
In this article we determined the thermal diffusion coefficient (DT) in equimolar mixtures of n-alkanes nCi–nC12 (i=5,6,7,8,9,17,18), nCi–nC10 (i=5,6,7,15,16,17,18), and nCi–nC6 (i=10,12,14,16,18) at 25°C atmospheric pressure using thermogravitational technique. The results obtained from study together with previously published ones series nCi–nC18 (i=5,6,7,8,9,10,11,12,13) show that main parameter determines DT each is association molecular weights mixture’s components. However, an...
Background Internal tandem duplications of the FLT3 gene (FLT3-ITDs) are frequent in patients with acute promyelocytic leukemia (APL), however its clinical impact remains controversial.Design and Methods We analyzed prognostic significance FLT3-ITD mutant level size, as well FLT3-D835 point mutations, PML-RARα expression other predictive factors 129 APL at diagnosis enrolled on Spanish LPA96 (n=43) or LPA99 (n=86) PETHEMA trials.Results FLT3-ITDs D835 mutations were detected 21% 9% patients,...
The physical and biological parameters involved in efficient transformation of Kluyveromyces lactis by electroporation have been analyzed. By using an optimum voltage a constant volume cell suspension cuvette, the efficiency increased with increases numbers plasmid concentration. However, most important parameter was time pulse. Changes 1 ms decreased more than 70 to 80%. Under our best conditions, between 10 6 7 transformants per μg DNA could be obtained. certain size also affected...
Vibrations of the resonance box guitar have been studied by means modal analysis technique and finite-element method. An expert craftsman constructed with all structures, internal external, characteristic a real instrument for experimental measurements. The boundary conditions were chosen in order to clarify soundboard-back interaction only via air coupling. numerical model allows one study influence each component on whole box, contribution modes components (wooden its parts, air), coupled...