A5101945794- Endoplasmic Reticulum Stress and Disease
- Immune Cell Function and Interaction
- Cardiac Valve Diseases and Treatments
- Genetics and Physical Performance
- COVID-19 Clinical Research Studies
- Antifungal resistance and susceptibility
- Cardiac Structural Anomalies and Repair
- Immune cells in cancer
- Sports Performance and Training
- Legionella and Acanthamoeba research
- Medieval Architecture and Archaeology
- Inflammasome and immune disorders
- Dermatology and Skin Diseases
- Cardiac Imaging and Diagnostics
- SARS-CoV-2 and COVID-19 Research
- Historical Art and Architecture Studies
- International Relations in Latin America
- Cardiac tumors and thrombi
- Case Reports on Hematomas
- Musicians’ Health and Performance
- Infective Endocarditis Diagnosis and Management
- Public Policy and Governance
- Healthcare Technology and Patient Monitoring
- Spinal Cord Injury Research
- Psoriasis: Treatment and Pathogenesis
Instituto de Biomedicina y Genética Molecular de Valladolid
2022-2024
Universidad de Valladolid
2017-2024
Icahn School of Medicine at Mount Sinai
2024
Universidad de La Laguna
2010
Tucson Medical Center
1977-2002
St. Joseph's Hospital
2002
Hospital de León
1994
St. Joseph Hospital
1990
Human monocyte-derived dendritic cells (DCs) exposed to pathogen-associated molecular patterns (PAMPs) undergo bioenergetic changes that influence the immune response. We found stimulation with PAMPs enhanced glycolysis in DCs, whereas oxidative phosphorylation remained unaltered. Glucose starvation and hexokinase inhibitor 2-deoxy-d-glucose (2-DG) modulated cytokine expression stimulated DCs. Strikingly, IL23A was markedly induced upon 2-DG treatment, but not during glucose deprivation....
Recognition of pathogen-associated molecular patterns can trigger the inositol-requiring enzyme 1 α (IRE1α) arm endoplasmic reticulum (ER) stress response in innate immune cells. This process maintains ER homeostasis and also coordinates diverse immunomodulatory programs during bacterial viral infections. However, role IRE1α signaling to fungal pathogens remains elusive. Here, we report that systemic infection with human opportunistic pathogen Candida albicans induced proinflammatory...
Increased glycolysis parallels immune cell activation, but the role of pyruvate remains largely unexplored. We found that stimulation dendritic cells with fungal surrogate zymosan causes decreases pyruvate, citrate, itaconate, and α-ketoglutarate, while increasing oxaloacetate, succinate, lactate, oxygen consumption, dehydrogenase activity. Expression IL10 IL23A (the gene encoding p19 chain IL-23) depended on Mechanistically, reinforced histone H3 acetylation, acetate rescued effect...
The present work represents working progress for designing a Graphical User Interface (GUI) within an ongoing research project named RAUVI (e.g. Reconfigurable AUV Intervention Missions). This GUI should help the user to identify target using images compiled by I-AUV through previous survey stage. After that, is able specify most suitable intervention task selected among set of predefined ones. Thus, very intuitive and user-friendly interface has been designed, enabling non qualified succeed...
Abstract Cytokine expression is fine-tuned by metabolic intermediates, which makes research on immunometabolism suitable to yield drugs with a wider prospect of application than the biological therapies that block proinflammatory cytokines. Switch from oxidative phosphorylation (OXPHOS) glycolysis has been considered characteristic feature activated immune cells. However, some stimuli might enhance both routes concomitantly. The connection between tricarboxylic acid cycle and cytokine was...
Abstract A 62‐year‐old woman with disabling mitral prosthetic stenosis underwent percutaneous balloon valvuloplasty. The transvalvular gradient preoperatively was 22 mm Hg and reduced to 6 after the valve area increased from an initial value of 0.77 cm 2 1.53 . No complications occurred related procedure. Further studies are necessary ascertain indications long‐term results valvuloplasty on bioprosthesis in position.
Presented are the results of use transfemoral approach for coronary arteriography, as a safe alternative to brachial approach, in evaluating patients cardiogenic shock. Five patients, each with an intraaortic balloon pump device operation, were evaluated. No complications encountered using approach.
Abstract Initial symptoms of COVID-19 infection depend on viral replication, while hyperinflammation is a hallmark critical illness and may drive severe pneumonia death. Among the mechanisms potentially involved in hyperinflammatory state, we focused unfolded protein response, because IRE1α-XBP1 branch can be activated as result endoplasmic reticulum stress produced by overwhelming synthesis components synergizes with Toll-like receptor signaling to induce cytokine expression. Viral RNA...
Increased glycolysis parallels immune cell activation, but the role of pyruvate flux remains largely unexplored. We show that stimulation dendritic cells with fungal surrogate zymosan induces a drop pyruvate, citrate, itaconate, and α-ketoglutarate, as well an increase in oxaloacetate, succinate, lactate, oxygen consumption, activation dehydrogenase activity. The expression IL10 IL23A (the gene encoding p19 chain IL-23) depended on mitochondrial Pyruvate underpinned histone H3 acetylation...
ABSTRACT Recognition of pathogen-associated molecular patterns can trigger the IRE1α arm endoplasmic reticulum (ER) stress response in immune cells. activation has been shown to maintain ER homeostasis while simultaneously coordinating diverse immunomodulatory programs setting bacterial and viral infections. However, role signaling innate responses fungal pathogens is unknown. Here we report that systemic infection with fungus Candida albicans causes severe renal immunopathology by...