A5100750634- Synthesis and Biological Evaluation
- Synthesis and biological activity
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- Molecular Sensors and Ion Detection
- Tuberculosis Research and Epidemiology
- Synthesis and Catalytic Reactions
- Synthesis and Reactions of Organic Compounds
- Analytical Chemistry and Sensors
- Chemical Synthesis and Analysis
- Cancer therapeutics and mechanisms
- Synthesis and Reactivity of Heterocycles
- Estrogen and related hormone effects
- Mass Spectrometry Techniques and Applications
- Electrochemical Analysis and Applications
- Garlic and Onion Studies
- Analytical Chemistry and Chromatography
- Malaria Research and Control
- Plant tissue culture and regeneration
- Phytochemicals and Antioxidant Activities
- Synthesis of heterocyclic compounds
- Synthesis of β-Lactam Compounds
- HIV/AIDS drug development and treatment
- Synthesis and bioactivity of alkaloids
University of Delhi
2025
University of Cape Town
2023-2024
Indian Veterinary Research Institute
2022-2023
Biocon (India)
2021-2023
Bristol-Myers Squibb (India)
2021-2023
Syngene International (India)
2023
Guru Nanak Dev University
1992-2022
IFTM University
2020
Indian Institute of Management Amritsar
2018-2019
Ubiquitous Energy (United States)
2018
Normal tissue damage from ionizing radiation during radiotherapy is a major concern in cancer treatment. Tea polyphenols (TPs) have been shown to reduce radiation-induced multiple studies, but their pharmacological application still limited due poor bioavailability. The present study was aimed at increase the TPs bioavailability by nanoformulation using BSA as matrix and chitosan external shell. Encapsulated nanoparticles were spherical size promoted stability normal gastrointestinal...
1H-1,2,3-Triazole tethered imidazole-isatin and imidazole-isatin-thiosemicarbazone conjugates were synthesized evaluated against MCF-7 MDA-MB-231 cell lines. Antiproliferative activities of the revealed an optimum combination longer alkyl chain length as spacer a halogen-substituent on isatin ring pre-requisite for good activity. The compound 6g with chloro-substituent at C-5 position butyl proved to be most active noncytotoxic IC50s 54.25 26.12 μM lines, respectively.
The present study was aimed to evaluate the radioprotective effects of naringenin in vivo using Swiss albino mice as a model system. Oral administration 50 mg/kg body weight for 7 days prior radiation exposure protected against radiation-induced DNA, chromosomal and membrane damage. Naringenin pretreatment also increased antioxidant status irradiated mice. Multiple factors operating at cellular molecular levels led endogenous spleen colonies survival Although induces apoptosis cancer cells...
hCLCA2 is frequently down-regulated in breast cancer and a candidate tumor suppressor gene. We show here that the gene strongly induced by p53 response to DNA damage. Adenoviral expression of induces variety cell lines. Further, we find binds consensus elements promoter mutation these sites abolishes p53-responsiveness induction transduction into immortalized cells p53, CDK inhibitors p21 p27, cycle arrest 24 hours, caspase apoptosis 40 hours postinfection. Transduction malignant line BT549...
A library of 1<italic>H</italic>-1,2,3-triazole-tethered ospemifene–isatin and ospemifene–spiroisatin conjugates have been synthesized evaluated for their anti-proliferative activities against MCF-7 MDA-MB-231 cell lines.
Tuberculosis remains a leading cause of mortality among infectious diseases worldwide, prompting the need to discover new drugs fight this disease. We report here design, synthesis, and antimycobacterial activity isatin-mono/bis-isoniazid hybrids. Most compounds exhibited very high against Mycobacterium tuberculosis, with MICs in range 0.195 0.39 μg/ml, exerted more potent bactericidal effect than standard antitubercular drug isoniazid (INH). Importantly, these were found be well tolerated...
In the recent decade, scientific communities have toiled to tackle emerging burden of drug-resistant tuberculosis (DR-TB) and rapidly growing opportunistic nontuberculous mycobacteria (NTM). Among these, two neglected species Acinetobacter family, Mycobacterium leprae ulcerans, are etiological agents leprosy Buruli ulcer infections, respectively, fall under broad umbrella tropical diseases (NTDs). Unfortunately, lackluster drug discovery efforts been made against these pathogenic bacteria in...
A series of amide tethered 4-aminoquinoline-naphthalimide hybrids has been synthesized to assess their in vitro antiplasmodial potential against chloroquine-susceptible (3D7) and chloroquine-resistant (W2) strains Plasmodium falciparum. The most active noncytotoxic compound had an IC50 value 0.07 μM W2 strain was more than standard antimalarial drugs, including chloroquine, desethylamodiaquine, quinine, particularly for drug resistant malaria. promising scaffold, when subjected heme binding...
Parasitic infections like amebiasis, trichomoniasis, and giardiasis are major health threats in tropical subtropical regions of the world. Metronidazole (MTZ) is current drug choice for giardiasis, trichomoniasis but it has several adverse effects potential resistance a concern. In order to develop alternative antimicrobials, library 1H-1,2,3-triazole-tethered metronidazole-isatin conjugates was synthesized using Huisgen's azide-alkyne cycloaddition reaction evaluated their amebicidal,...
Aim: WHO Malaria report 2017 estimated 216 million cases of malaria and 445,000 deaths worldwide, with 91% affecting the African region. Results/methodology: Microwave promoted synthesis cycloalkyl amine substituted isoindoline-1,3-dione-4-aminoquinolines was urbanized for evaluating their antiplasmodial activities. Compound optimum combination propyl chain length hydroxyethyl piperazine proved to be most potent among synthesized scaffolds against chloroquine-resistant W2 strain Plasmodium...
An improved synthetic protocol has been developed to construct highly functionalized heterologous alkyl and benzyl indolyl-coumarin derivatives using a rapid, catalyst-free solvent-free one-pot three-component reaction of indole, aldehyde 4-hydroxy-coumarin.
A series of novel heterocyclic analogs chalcone containing isoxazole and benzoxazinone ring as a prime motif was rationally designed synthesized. There is nothing in the literature about such α,β-unsaturated ketones.
Rapid growth of global drug-resistant tuberculosis and urgent requirement for short treatment regimens is stimulating the need discovery new TB drugs. In this work, we report design, synthesis in vitro antimycobacterial evaluation a library isatin-derived bis(heteronuclear hydrazones). Evaluation results revealed that inclusion isoniazid core into 1H-1,2,3-triazole tethered isatin-benzaldehydes improved activity on mc2 6230 strain significantly reduced cytotoxicity against Vero cells....