Summary The incidence and prevalence of fungal infections in Russia is unknown. We estimated the burden according to methodology LIFE program (www. ‐worldwide.org). total number patients with serious chronic mycoses 2011 was three million. Most these (2607 494) had superficial (recurrent vulvovaginal candidiasis, oral oesophageal candidiasis HIV infection tinea capitis). Invasive (invasive invasive aspergillosis, cryptococcal meningitis, mucormycosis Pneumocystis pneumonia) affected 69 331...

Chronic obstructive pulmonary disease (COPD) is one of the most common bronchopulmonary diseases. Eosinophilic inflammation respiratory tract in COPD requires further search for new markers diagnosis and determination therapy strategy. Aim: periostin level assessment its significance as a marker eosinophilic patients with COPD. The study included 45 (males at median age 65). Medical history, results clinical instrumental studies were evaluated. levels total IgE determined blood serum by...

Summary Introduction Allergic bronchopulmonary aspergillosis (ABPA) is a lung disease in patients with asthma or cystic fibrosis (CF) caused by chronic allergic inflammation to Aspergillus spp. antigens. The role of different immunological mediators the formation ABPA not sufficiently explored. Objectives This study aimed investigate serum levels thymic stromal lymphopoietin (TSLP), thymus and activated chemokine (TARC) as well IL‐8 ABPA, evaluate their diagnostic monitoring value disease....

Aim. To estimate the frequency of fungal sensitization and incidence allergic bronchopulmonary aspergillosis (ABPA) in asthmatic patients. Subjects methods. A total 140 patients were examined. They underwent allergologic (skin tests for allergens, estimation allergen-specific IgE levels) mycological (microscopy inoculation respiratory biosubstrates) examinations. Chest computed tomography, when indicated, was done. group with ABPA that severe asthma identified. Results. The 36%; main...

The aim : to assess the incidence of various forms pulmonary aspergillosis in patients with cystic fibrosis. Materials and methods. In 2014-2017 yy. prospective study different regions Russia were included 190 fibrosis aged 1 37 years. Children – 130, adults 60. All underwent allergy (skin tests fungal allergens, total IgE level, specific allergens) mycology (microscopy cultural investigations respiratory biomaterials) testing. Chest computed tomography was performed according indications....

BACKGROUND: Asthma and chronic obstructive pulmonary disease are common respiratory diseases. Given their heterogeneity, the study of periostin is a relevant area for establishing endotypes airway inflammation determining further therapy tactics. AIM: To evaluate levels determine its significance as marker eosinophilic in patients with asthma disease. MATERIALS AND METHODS: The included 59 33 control group consisted 37 apparently healthy people, comparable age sex, without allergic bronchial...

Allergic bronchopulmonary aspergillosis (ABPA) is a caused by hypersensitivity to Aspergillus spp. antigens, the lung disease, which occurs in patients with asthma or cystic fibrosis and characterized poor control of background disease development respiratory failure. According experts opinion number ABPA about four million people world 175 000 persons Russian Federation. The clinical course improvement, prevention progression prophylaxis bronchiectasis depend on timely correct diagnosis...

BACKGROUND: Asthma is considered one of the urgent medical and social problems XXI century. In recent years, not only an increase in incidence, but also prevalence severe forms asthma has been noted all countries world. The effect sensitization spectrum on severity level control studied enough.
 AIM: Evaluate importance to aeroallergens patients as indicators for disease exacerbation risk.
 MATERIALS AND METHODS: Single-center cross-sectional study at North-Western State Medical...

Studies of probable significance different immunological mediators for the development chronic allergic inflammation in patients with bronchopulmonary aspergillosis (ABPA) are necessary order to specify potential targets therapeutic intervention and timely diagnosis disease. The purpose present study was determine features immune response regulation, identify diagnostic markers associated ABPA bronchial asthma, evaluate clinical efficacy specific antimycotic therapy. involved 13 ABPA, 14...

Aspergillus fumigatus colonization in the patients with cystic fibrosis (CF) may cause sensitization against A. and/or allergic bronchopulmonary aspergillosis (ABPA), which significantly worsens course of underlying disease. At present time, new diagnostic tests are searched for detection fungal these patients. The aim this work was to evaluate an opportunity application basophile activation test allergen vitro using flow cytometry, aiming identification CF study included 190 aged 1 37...

Aim: to assess the clinical and immunological characteristics of patients with severe bronchial asthma (BA) Aspergillus sensitization study possibilities applying basophil activation test (BAT) using flow cytometry detect mycogenic sensitization. Patients Methods: 93 BA were examined. Therapy had 4 or 5 steps according GINA 2019 recommendations. TARC (thymus activation-regulated chemokine) content, number eosinophils, levels total IgE specific 10 allergens determined in blood serum by enzyme...

Background. Fungal sensitization is associated with severe uncontrolled asthma. Connections of specific, micromycetes and fungal allergens disease development immunopathogenesis asthma are not well understood. Methods. The study included 120 patients different grades severity. Results. was detected in 48 (40%). Severe course identified 7 (14,6%). main were Alternaria spp. Aspergillus spp., mild moderate - Penicillium Increasing serum total IgE enhancing the ability blood cells to produce IL2...

Background. To determine the frequency of allergic bronchopulmonary aspergillosis in patients with asthma and to study dynamics immunological parameters during antimycotic therapy. Methods. During investigation 176 group was isolated. Allergological (skin tests fungal allergens, serum total IgE, specific IgE allergens), (IFN-γ, IL-10) mycological (microscopy culture respiratory samples) examination performed. Computer tomography chest done when indicated. Results. In sensitization...

Adult-onset Still’s disease (AOSD) is a systemic autoinflammatory mediated by interleukin (IL)-1 production. There are no treatment guidelines for AOSD due to its rarity and heterogenous manifestations. Therefore, each case challenging requires multidisciplinary approach. We report of occurring in pregnant patient who did not respond standard with glucocorticoids developed skin reaction IL-1 receptor antagonist. However, drug desensibilisation was effective allowed continue anakinra.

Immunological characteristics of airway inflammation in asthma patients with sensitization to various fungal allergens are not well understood, and the search for new markers is necessary establish future targets targeted therapy. The purpose our study was assess levels eosinophilic respiratory tract severe allergic bronchopulmonary aspergillosis, depending on spectrum sensitization.
 included 31 29 aspergillosis (ABPA). total, specific IgE periostin blood serum were determined by...

The etiology of precocious puberty includes organic anomalies, genetic mutations, but the primary cause remains unclear in vast majority cases. Gonadotropin-releasing hormone (GRH) agonists are used as a treatment gonadotropin-dependent puberty. Blocking secretion gonadotropin-releasing hormone, these drugs stop premature development sexual features, prevent closure ossification zones, thereby increasing child’s expected adult height. interest effects this group beyond...

Introduction. Allergy to microscopic fungi (micromycetes), which can colonize the respiratory tract, is associated with an eosinophilic endotype of inflammation and severe disease course. Among hallmarks fungal allergy, experts identify fixed airways obstruction, bronchiectasis, fibrosis. Currently, there has been proposed term “allergic disease” (AFAD), combines various clinical phenotypes, pathogenesis based on IgE-mediated allergic reaction against spores colonizing tract. According this...

Allergic rhinitis (AR) is one of the most common diseases. Basic AR therapy includes both antihistamines second generation for per os administration in mild AR, and intranasal corticosteroids treatment moderate AR. In clinical practice, oral (in combination with corticosteroids) can be rationally replaced antihistamines. Momate Rhino Advance nasal spray (a azelastine hydrochloride mometasone furoate) promising medication when used as firstline severe manifestations

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Background. To estimate the frequency of fungal sensitization and allergic bronchopulmonary aspergillosis in patients with asthma or cystic fibrosis. Methods. The study included 205 190 For detection specific IgE antibodies blood serum «AllergoELISA-specific IgE» test system biotinylated allergens were determined. Mycological examination microscopy cultural respiratory biomaterials. According to indications, a CAT scan chest was performed. Results. incidence 35,6%, CI [29,1%; 42,6%],...

The formation of fungal biofilms remains a serious medical problem.In particular, once are formed, they display high levels resistance against most common antifungals.Candida albicans and Candida dubliniensis closely related organisms with respect to morphology phylogeny, but differ in their expression virulence-associated proteins involved adherence biofilm development.Complement receptor 3-related protein (CR3-RP) is one the key surface antigens expressed by many pathogenic species...

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