A5081809084- Cystic Fibrosis Research Advances
- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
- Human Health and Disease
- Nutrition, Genetics, and Disease
- Inhalation and Respiratory Drug Delivery
- Healthcare Systems and Public Health
- Respiratory viral infections research
- Nutritional Studies and Diet
- Pneumonia and Respiratory Infections
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Risk Factors
- Immunodeficiency and Autoimmune Disorders
- Asthma and respiratory diseases
- Obesity, Physical Activity, Diet
- Digestive system and related health
- Pregnancy and preeclampsia studies
- Respiratory and Cough-Related Research
- Tracheal and airway disorders
- Lightning and Electromagnetic Phenomena
- Clostridium difficile and Clostridium perfringens research
- Respiratory Support and Mechanisms
- Bacterial Infections and Vaccines
- Cardiovascular Health and Disease Prevention
- Nosocomial Infections in ICU
North-Western State Medical University named after I.I. Mechnikov
2020-2025
Ministry of Health of the Russian Federation
2023-2025
St. Petersburg State Medical Academy "City Hospital No. 26"
2025
City Clinical Hospital No. 2
2023
Moscow Power Engineering Institute
2002-2021
Federal Almazov North-West Medical Research Centre
2015-2019
City Clinical Hospital
2019
State Hospital
2018
City Hospital No. 40
2015
Institute of Experimental Cardiology
2013
In the Russian Federation, patients with cystic fibrosis (CF) under 19 years of age receive targeted therapy two drugs: lumacaftor/ivacaftor and elexacaftor/tezacaftor/ivacaftor. Currently, a large volume information has accumulated regarding possible adverse drug reactions (ADRs) during long-term in children CF. The aim study was to investigate ADR profile associated use CFTR modulators Methods. Data on were taken from registry CF (2021 – 2024). data 392 at start lumacaftor/ivacaftor, 196...
to elucidate prevalence of phenotypes metabolically heathy obesity (MHO) among inhabitants Saint-Petersburg using various criteria and assess dependence levels adipokines on phenotype.Within a framework epidemiologic study ESSE-RF we formed random sample 1600 stratified according gender age. Examination participants included anthropometry with measurement waist circumference CRP estimation body mass index (BMI), arterial pressure, determination fasting blood glucose, insulin (with...
The article discusses results of a prospective observational study long-term use the biosimilar dornase alfa (Tigerase) (Generium, Russia) as part complex therapy in patients with cystic fibrosis real clinical practice. aim was to analyze outcomes CF (protocol #DRN-CFR-N01). Methods. included ( n = 165) aged 5 years and older from 11 centers for treatment Russian Federation confirmed diagnosis who were prescribed by their attending physician. Results. analysis revealed that exacerbations...
Aim: Genetic, clinical, laboratory-instrumental and morphological characteristics of genetic dysfunctions the surfactant system in children, therapy outcomes disease. Design: Multicentre, ambispective, open-label, descriptive pilot longitudinal study. Materials methods. We observed 17 children from 16 families with identified mutations SFTPC, ABCA3, NKX2-1 genes. Methods used: genealogical, Sanger sequencing, clinical exome computed tomography histological examination lungs. Results. The...
Lumacaftor/ivacaftor is a combination of two low-molecular-weight drugs aimed at eliminating the main defect cystic fibrosis (MV) cellular level. Restoration function chlorine (CFTR) channel in MV necessary for normalization mucociliary clearance, nutritional status patients, improvement other clinical and laboratory parameters. This CFTR modulator approved treatment homozygotes according to F508del variant, most common among patients with MV. Objective: study effectiveness...
Accepted, basic therapy of cystic fibrosis (CF), until recently, was symptomatic and aimed at slowing down pathological processes, mainly from the respiratory system gastrointestinal tract, caused by a defect in CFTR gene. New strategic opportunities have emerged since 2012 are correcting gene or its product. A mutation disrupts function transmembrane conductance regulator protein (CFTR English transcription), which is located on surface apical membrane epithelial cells functions as chloride...
The purpose of the study was to determine predictors severe bronchiectasis (BE) not associated with cystic fibrosis (CF) in children and evaluate effectiveness a stepwise complex conservative therapy. Materials methods study: design - multicenter cohort prospective pilot study. 67 hospitalized pediatric patients aged from 11 months up 17 years old (52% boys 48% girls) BE caused by previous pneumonia (22%), primary ciliary dyskinesia bronchial asthma (13%), Williams-Campbell syndrome (7%),...
Aim. To establish the etiological structure and to present clinical laboratory instrumental characteristics of bronchiectasis (BE) not associated with cystic fibrosis (CF) in children.
 Materials methods. Sixty-seven hospitalised patients BЕ related CF were followed up between 2017 2022. Examination methods: clinical-anamnestic method, general investigations, investigation allergological immune status, phagocytosis system, determination concentration specific IgE IgG fungi genus...
Aim. To study the relation of emotional status with negative tendencies in food preference style Russian population, including regional specifics Saint-Petersburg, Samara and Orenburg. Material methods. The is part ESSE-RF (Epidemiology Cardiovascular diseases different regions Federation). Totally 1941 men 2859 women studied at age 25-64 y.o. — citizens socio- demographic data assessed, as absence/presence cardiovascular disorders, diabetes gastrointestinal disorders (by self-report), some...
Aim. To assess the relation of obstructive sleep apnea syndrome (OSAS) by data Berlin questionnaire and risk fatal cardiovascular events. Material methods. Totally, 275 persons studied (115 males, 160 females) age 25-64 y.o., with unknown complications, underwent structured interview. The sleep-disordered breathing was assessed questionnaire, — SCORE. Anthropometric parameters were studied, as lipid profile, fasting glucose, uric acid, creatinine, C-reactive protein, adiponectin, leptin....
Objective: to assess the presence and degree of bronchial hyperreactivity in convalescents whooping cough based on results provocation tests. Materials methods . Using provocative samples with a 0,02/0,33% histamine solution 0,33% methacholine PROVOTEST-2 apparatus from PARI, was studied 12 pertussis aged 7 17 years. The level endogenous nitrogen monoxide exhaled air (FeNO) measured using portable NObreath electrochemical analyzer (from Bedfont Scientific Ltd.). results. According BPP, 6...
The aim of this study was to evaluate clinical efficacy and safety highly concentrated inhaled solution tobramycin (Bramitob ® , Chiesi Farmaceutici S.p.A., Italy) in patients with cystic fibrosis (CF). This 24-wk multicenter international double-blind placebo-controlled randomized trial parallel groups. In study, 247 aged 6–45 yrs Pseudomonas aeruginosa yielded sputum FEV 1 40 % 80 pred. were 2 groups: those inhaling aerosol (161 patients, mean age, 14.8 ± 5.7 yrs) or placebo (84 14.7 6.6...
The possibility of using a long laser spark for protecting objects against lightning is studied. Conditions under which the electric charges from clouds can be guided reproducibly along are found. Experiments reveal that interaction between and discharge an electrode rod (lightning rod) leads to decrease in lifetime streamer corona burst, as well increase current developing leader its velocity compared case without spark.
The aim : to assess the incidence of various forms pulmonary aspergillosis in patients with cystic fibrosis. Materials and methods. In 2014-2017 yy. prospective study different regions Russia were included 190 fibrosis aged 1 37 years. Children – 130, adults 60. All underwent allergy (skin tests fungal allergens, total IgE level, specific allergens) mycology (microscopy cultural investigations respiratory biomaterials) testing. Chest computed tomography was performed according indications....
This was an observational prospective cohort study of safety and efficacy mucolytic therapy with i nhaled combination 7% hypertonic saline (HS) 0.1% hyaluronic acid (HA) in patients cystic fibrosis (CF). The treatment duration 4 weeks, the follow-up continued up to 8 weeks. Methods. involved 74 CF aged > 12 years. A comparative analysis respiratory function, patients’ satisfaction therapy, 4-wk performed groups treated HS (n = 33) or HA 41). Changes status 41) were assessed after Results....
The article discusses data on the lithological composition of bottom sediments from two small lakes – Lake Lavkozero and Gangozero, located Zaonezhsky Peninsula, within area Onega Ice Lake. In recovered sediment sequences studied lakes, units top to down have been recognized: Holocene gyttja isolated Late Pleistocene Lake, which are represented by varved clays silts. Based data, a “pink horizon” was identified. It is similar one found in section Unitskaya Bay Onega. absolute hypsometric...
Детская Городская Больница Святой Ольги,
Cystic fibrosis (CF) is a systemic hereditary disease caused by mutation of the CFTR gene and characterized damage to glands external secretion severe dysfunctions respiratory system. The “severe” genotypes are associated with more pronounced early clinical manifestations. “mild” delayed onset Methods. An analysis medical history patients asymptomatic CF from Russian centers was carried out. Rectal biopsy specimens were used for intestinal current measurement (ICM) forskolin-induced swelling...
Results of experimental investigations optical characteristics discharges from an artificial cloud charged water aerosol by using the K011miniature 9-frame image converter camera are presented in paper. Application high speed has allowed clearly distinguished peculiarities a final stage three types clouds. Each type is differed not only on and current characteristics, but sequence formation. It was found that depends character development previous leader gap "charged cloud-grounded rod...