A5087554653- Cystic Fibrosis Research Advances
- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
- Immunodeficiency and Autoimmune Disorders
- Respiratory viral infections research
- Bacterial biofilms and quorum sensing
- Infections and bacterial resistance
- Inhalation and Respiratory Drug Delivery
- Tracheal and airway disorders
- Pneumonia and Respiratory Infections
- Human Health and Disease
- Pancreatitis Pathology and Treatment
- Antibiotic Resistance in Bacteria
- Nematode management and characterization studies
- Gastrointestinal disorders and treatments
- Neonatal and Maternal Infections
- Burkholderia infections and melioidosis
- Digestive system and related health
- Plant Pathogenic Bacteria Studies
- Asthma and respiratory diseases
- Tissue Engineering and Regenerative Medicine
- Child Nutrition and Water Access
- Child Nutrition and Feeding Issues
- Pulmonary Hypertension Research and Treatments
- Legume Nitrogen Fixing Symbiosis
Pirogov Russian National Research Medical University
2018-2024
Russian Children's Clinical Hospital
2010-2024
Ministry of Health of the Russian Federation
2019-2024
Moscow Power Engineering Institute
2020
Moscow Aviation Institute
2020
Scientific Center of Children's Health
2019
Research Institute of Obstetrics and Gynecology named after D.O. Ott
2019
Laboratory of Molecular Genetics
2018
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation
2018
All-Russian Scientific Research Institute of Irrigation and Agricultural Water Supply "Raduga"
2017
The problem of timely diagnosis and proper management patients with cystic fibrosis is crucial not only in our country, but throughout the world. Experts Union Pediatricians Russia have considered various issues etiology, pathogenesis, epidemiology, diagnosis, treatment this genetic disease a modern light. Particular attention was paid to screening methods for early fibrosis. principles complex therapy were justified, including rational use antibacterial mucolytic drugs enzyme replacement...
Background and aims. Achromobacter spp., as causative agent of the nosocomial infections, has caught eye last Decades. The growth infecting respiratory tract cystic fibrosis patients by this microorganism is formidable. aim investigation was spp. identification in expanded cohort Russian CF patients, genotyping according to international standards molecular epidemiological analysis situation with opportunistic microorganism. Methods. Clinical samples from about 300 patients: sputum, tracheal...
Summary. The aim of this study was to evaluate changes in survival patients with cystic fibrosis (CF) Moscow and region determine factors influencing the survival. We analyzed outpatient medical records followed-up CF centers by 1st January, 2002, 2012. Median for 2002–2012 37.2 years; significantly higher that similar value previous decade (25.9 years). A total number more than doubled due increased improved diagnosis disease. Improved work implementation effective medications, primarily...
Stenotrophomonas maltophilia is a common opportunistic microorganism and an important respiratory pathogen in cystic fibrosis (CF). The aim of this study was to determine antimicrobial resistance phenotypes, sequence-types (ST) genetic determinants antibiotic S. strains recovered from CF patients Russia. isolates 170 were analyzed. Minimum inhibitory concentrations antibacterial agents determined using Sensititre Gram Negative GNX2F plates the results interpreted according Clinical...
<b><i>Background:</i></b> Anti-inflammatory therapy is a logical approach to slowing the inevitable lung function deterioration in cystic fibrosis (CF) patients. This study's aim was evaluate inflammatory markers and disease progression paediatric CF patients chronically treated with azithromycin or low-dose prednisolone.<b><i> Methods:</i></b> The study included 204 100 healthy controls; 102 were basic only (without anti-inflammatory...
The article discusses results of a prospective observational study long-term use the biosimilar dornase alfa (Tigerase) (Generium, Russia) as part complex therapy in patients with cystic fibrosis real clinical practice. aim was to analyze outcomes CF (protocol #DRN-CFR-N01). Methods. included ( n = 165) aged 5 years and older from 11 centers for treatment Russian Federation confirmed diagnosis who were prescribed by their attending physician. Results. analysis revealed that exacerbations...
In current literature there are only scarce data on the host inflammatory response during Burkholderia cepacia complex (Bcc) persistence. The primary objective of present research was to carry out cross-sectional analyses biomarkers and evaluate disease progression in cystic fibrosis (CF) patients with chronic Bcc infection pathogen-free ones. secondary aim assess prospectively overall survival study participants up 8 years follow-up. included 116 paediatric CF; 47 CF were chronically...
Детская Городская Больница Святой Ольги,
The pulmonary drug administration for the treatment of a affection in cystic fibrosis is highly effective. This consensus document summarizes data on inhalation intake bronchodilators, mucolytics, anti-inflammatory drugs, including glucocorticoids, recommended use patients all age groups territory Russian Federation
Cystic fibrosis (CF) is a common genetic disease, manifested by airway obstruction and chronic respiratory infection. The most prevalent infectious agent in airways of CF patients Pseudomonas aeruginosa. This study aimed to determine sequence-types, antimicrobial resistance phenotypes genes defining adaptive antibiotic P. aeruginosa isolates recovered from Russia. In total, 84 strains 64 were analyzed. Susceptibility antibiotics was determined disk diffusion test. Whole-genome sequencing...
<b>Background:</b> Chronic infection with <i>Burkholderia cepacia</i> complex (Bcc) in patients cystic fibrosis (CF) is associated accelerated loss of lung function and increased mortality. In current literature there are a lot the data on Bcc genetics, quorum sensing system, virulence factors. However, very little known about changes host inflammatory response during chronic persistence. <b>Objectives:</b> This study’s aim was to perform cross-sectional analyses local systemic biomarkers CF...
Cystic fibrosis (CF) is a hereditary autosomal recessive disease that affects all exocrine glands, leading to severe impairment of the respiratory and digestive systems.CF caused by deleterious mutations in CFTR gene (CFTR stands for cystic transmembrane conductance regulator) [1], most commonly F508del (rs113993960) which results deletion phenylalanine at position 508 protein [1][2][3].There no known cure CF; complex care should be provided patients with CF throughout their lifetime.CF one...
The aim of the study was to determine clinical and genetic features syndrome undifferentiated connective tissue dysplasia (CTD) in cystic fibrosis (CF) children possible modifying effect polymorphisms genes on development severe pathology bronchopulmonary system CF cases. 188 patients with moderate course СF, aged from 3 17 years were examined. In СF significant associations have been established between matrix metalloproteinase 3, phenotypic signs CTD respiratory disorders.
Background : The basis of the treatment patients with cystic fibrosis (CF) is kinesitherapy — a special respiratory gymnastics and drainage bronchial tree. increase efficiency complex medical rehabilitation measures can be reached by application method high-frequency chest wall oscillation (HFCWO). Aim: To develop additional criteria individual program classes HFCWO system for children CF. Patients methods research involved 43 CF at age 2 years 10 months 17.5 whose included 14 procedures....