A5010570540- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Response and Inflammation
- Antifungal resistance and susceptibility
- Ocular Infections and Treatments
- Aquaculture disease management and microbiota
- Pharmaceutical and Antibiotic Environmental Impacts
- Bone Metabolism and Diseases
- Inflammatory mediators and NSAID effects
- Microbial infections and disease research
- Animal testing and alternatives
- Bone fractures and treatments
- Bone and Joint Diseases
- Computational Drug Discovery Methods
- Marine Sponges and Natural Products
- Zebrafish Biomedical Research Applications
- Estrogen and related hormone effects
- Effects and risks of endocrine disrupting chemicals
Clemson University
2020-2024
University of Houston
2019
Glucocorticoids are a major class of therapeutic anti-inflammatory and immunosuppressive drugs prescribed to patients with inflammatory diseases, avoid transplant rejection, as part cancer chemotherapy. However, exposure these increases the risk opportunistic infections such fungus Aspergillus fumigatus, which causes mortality in >50% infected patients. The mechanisms by glucocorticoids increase susceptibility A. fumigatus poorly understood. In this article, we used zebrafish larva infection...
Invasive aspergillosis is a common opportunistic infection, causing >50% mortality in infected immunocompromised patients. The specific molecular mechanisms of the innate immune system that prevent pathogenesis invasive immunocompetent individuals are not fully understood. Here, we used zebrafish larva-Aspergillus infection model to identify cyclooxygenase (COX) enzyme signaling as one mechanism promotes host survival. Larvae exposed pan-COX inhibitor indomethacin succumb at significantly...
Abstract Triazoles are a major group of azole fungicides commonly used in agriculture, and veterinary human medicine. Maternal exposure to certain triazole antifungal medication causes congenital malformations, including skeletal malformations. We hypothesized that triazoles as pesticides agriculture also pose risk causing malformations developing embryos. In this study, teratogenic effects three triazoles, cyproconazole, paclobutrazol, triadimenol, were investigated zebrafish, Danio rerio....
Invasive aspergillosis (IA) is one of the most common fungal infections among immunocompromised individuals. Despite availability antifungal drugs, IA can cause >50% mortality in infected patients. It crucial to determine both host and pathogen factors that contribute infection susceptibility low survival rates patients order develop novel therapeutics. Innate immune responses play a pivotal role recognition clearance Aspergillus spores, though little known about exact cellular molecular...
Abstract Glucocorticoids are a major class of therapeutic anti-inflammatory and immunosuppressive drugs prescribed to patients with inflammatory diseases, avoid transplant rejection, as part cancer chemotherapy. However, exposure these increases the risk opportunistic infections such fungus Aspergillus fumigatus . Prolonged glucocorticoid therapy is one main risks for invasive aspergillosis, which causes mortality in >50% infected patients. The mechanisms by glucocorticoids increase...
Invasive aspergillosis (IA) is one of the most common fungal infections among immunocompromised individuals. Despite availability antifungal drugs, IA can cause >50% mortality in infected patients. It crucial to determine both host and pathogen factors that contribute infection susceptibility low survival rates patients order develop novel therapeutics. Innate immune responses play a pivotal role recognition clearance Aspergillus spores, though little known about exact cellular molecular...
Abstract Invasive aspergillosis is a common opportunistic infection, causing >50% mortality in infected immunocompromised patients. The specific molecular mechanisms of the innate immune system that prevent pathogenesis invasive immunocompetent individuals are not fully understood. Here, we used zebrafish larva- Aspergillus infection model to identify cyclooxygenase (COX) enzyme signaling as one mechanism promotes host survival. Larvae exposed pan-COX inhibitor indomethacin succumb at...