A5054463841- Synthesis and biological activity
- Quinazolinone synthesis and applications
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Cancer therapeutics and mechanisms
- Research on Leishmaniasis Studies
- Synthetic Organic Chemistry Methods
- Influenza Virus Research Studies
- Click Chemistry and Applications
- Synthesis and Reactions of Organic Compounds
- Parasites and Host Interactions
- Carbohydrate Chemistry and Synthesis
- Parasite Biology and Host Interactions
- Asymmetric Synthesis and Catalysis
- SARS-CoV-2 and COVID-19 Research
- Multicomponent Synthesis of Heterocycles
- Respiratory viral infections research
- Synthesis of heterocyclic compounds
- Synthesis of Tetrazole Derivatives
- Phenothiazines and Benzothiazines Synthesis and Activities
- Bacterial biofilms and quorum sensing
- Glycosylation and Glycoproteins Research
- Virology and Viral Diseases
- Redox biology and oxidative stress
- Glutathione Transferases and Polymorphisms
Rustaq College of Education
2021-2024
National Research Centre
2011-2024
Taif University
2011-2018
National Water Research Center
2007-2018
Marquette University
2002-2003
SARS-CoV-2 is a newly emerged coronavirus that causes respiratory disease with variable severity and fatal consequences. It was first reported in Wuhan subsequently caused global pandemic. The viral spike protein binds the ACE-2 cell surface receptor for entry, while TMPRSS2 triggers its membrane fusion. In addition, RNA dependent polymerase (RdRp), 3′–5′ exoribonuclease (nsp14), proteases, N, M proteins are important different stages of replication. Accordingly, they attractive targets...
Global spread and regional endemicity of H5Nx Goose/Guangdong avian influenza viruses (AIV) pose a continuous threat for poultry production zoonotic, potentially pre-pandemic, transmission to humans. Little is known about the role mutations in viral neuraminidase (NA) that accompanied bird-to-human support AIV infection mammals. Here, after detailed analysis NA sequence human H5N1 viruses, we studied A46D, L204M, S319F S430G virus fitness vitro vivo . Although carrying avian- or human-like...
Nitrogen and sulfur-containing heterocyclic aromatic derivatives play an enormous important role in the field of medicine synthesis pharmaceutically active compounds. In this study, a series new 2-[1-(1,3-diphenyl-1H-pyrazol-4-yl)ethylidene]hydrazinyl)-4-methyl-5-aryldiazinyl)-thiazole (9a–d) was synthesized by efficient convenient method reacting hydrazonoyl chloride (4) with carbothioamide derivative (3). The structures these compounds were elucidated using elemental analyses,...
A novel series of 2,4‐disubstituted oxazole derivatives were synthesized, screened for their anti‐tumor activity against three cell lines MCF‐ 7 , TK‐10, and UACC‐62. Molecular docking study was carried out epidermal growth factor receptor. new 2‐phenyl‐4‐substituted synthesized. chiral α‐amino acid 6 8 9 10 11 12 13 14 15 synthesized by coupling various l ‐acylated amino azide 3. The compounds tested in vitro antitumor MCF‐7, UACC‐62 lines. Compound exhibited the strongest inhibitory TK...
Microwave solvent‐free technique was employed to the synthesis of series 2‐(1 H ‐perimidin‐2(3 )‐ylidene) derivatives, 4‐(1 ‐perimidin‐2‐yl)‐1 ‐pyrazole‐3‐carboxamides, pyrrolo[1,2‐ a ]perimidin‐10‐ones, and 8 ‐[1,2,4]triazolo[4,3‐ ]perimidine. Compared with conventional method, obvious feature microwave method is higher in chemical yield, faster reaction rate, cleaner condition. The structures synthesized compounds were confirmed based on their elemental analyses spectroscopic data (FT‐IR,...
A series of new thiopyrimidine derivatives were synthesized via the reaction ethyl cyanoacetate with thiourea and appropriate aldehydes namely, 3-methoxy-benzaldehyde, 2, 5-dimethoxy-benzaldehyde 3,5-dimethoxy-benzaldehyde to give corresponding pyridine thiones 1a-c. Compounds 1a-c then chlorinated chloro compounds 2a-c, which underwent variant cyclocondensation reactions afford different cyclized 3-10. On other hand, condensed monochloroacetic acid 11-14. Some selected for cytotoxicity...
A series of novel pyrrolo[2,1-b][1,3]oxazepine-8,9-diol derivatives 12–15 were synthesized starting from l-tartaric acid, which was transformed into anhydride then reacted with allylamine in xylene to afford the imide 2. The target molecules achieved via ring-closing metathesis Grubbs catalyst, followed by reduction carbonyl group and deprotection hydroxyl groups. Finally, catalytic hydrogenation double bond afforded title compounds 12–15. Molecular docking study carried out against...
A novel series of 1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one derivatives were synthesized. The synthesis started with the important building block 3, which was prepared via coupling from 2-(bi's (methylthio) methylene) malononitrile 1 4-amino-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one 2. 5-aminopyrazole 4-8 cyclocondensationof 3 appropriate sulfonohydrazides and pyridine- 4-carbohydrazide respectively. Cyclocondensation or 9 pyridine-4-carbohydrazide 4-methylbenzene...
Abstract A structurally diverse series of Δ 4,5 ‐uronamide derivatives have been chemically synthesized starting from D‐glucuronic acid itself by means acetylation, activation, amide bond formation and base‐catalyzed elimination protocols. Structure elucidation for all products along with optimization the synthetic steps is described. The compounds were evaluated their in‐vitro anti‐tumor activity against MCF‐7, TK‐10 UACC‐62 cell lines. 5 , 11 13 15 16 most active line. On other hand, MCF‐7...
A series of D-glucuronic acid derivatives were chemically synthesized including acetylated and deacetylated glucuronamides, as well N-glucuronides starting from the itself by means protection/deprotection, activation condensation protocols. Structure elucidation all products along with optimization synthetic steps is described. The compounds evaluated for their in vitro antitumor activity against MCF-7, TK-10 UACC-62 cell lines. 4, 5, 7, 8, 14, 16 18 most active line. On other hand, MCF-7...
Abstract The ring‐closure metathesis of the diene (2S,3R,4S)‐1‐(tert‐butyldiphenylsilyloxy)‐2,4‐dimethylhex‐5‐en‐3‐yl acrylate produced dihydropyrone with correct stereochemistry for Soraphen A1α synthesis. C2,C3 stereocenters were introduced by addition (Z)‐crotyl‐n‐butylstannane to β‐alkoxyaldehyde(S)‐3‐(benzyloxy)‐2‐methylpropanal in presence TiCl4 as a chelating catalyst give desired anti,syn homoallyic alcohol (2S,3R,4S)‐1‐(tert‐butyldiphenylsilyloxy)‐2,4‐dimethylhex‐5‐en‐3‐ol.
S OME new and known substituted 1,2,3,4-tetrahydroacridines incorporated at their position nine with various sulfa drug or thiosemicarbazide moieties were synthesized.Biologically, these compounds investigated for antiproliferative activity against human breast cancer (MCF-7) cell line compared to murine fibroblast normal (BALB/3T3).The results calculated as the IC 50 (inhibitory concentration 50%) Cisplatin control.Furthermore, a docking simulation study was carried out predict inhibitory...