A5059689447- Antimicrobial agents and applications
- Dendrimers and Hyperbranched Polymers
- RNA Interference and Gene Delivery
- Antimicrobial Peptides and Activities
- Pomegranate: compositions and health benefits
- Antioxidant Activity and Oxidative Stress
- Microbial metabolism and enzyme function
- Phytochemicals and Antioxidant Activities
- Chemical Synthesis and Reactions
- Essential Oils and Antimicrobial Activity
- Nanoplatforms for cancer theranostics
- Bacterial biofilms and quorum sensing
- Chemical Synthesis and Analysis
- Antibiotic Resistance in Bacteria
- Phenothiazines and Benzothiazines Synthesis and Activities
- Advanced biosensing and bioanalysis techniques
- Cancer therapeutics and mechanisms
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Nanoparticles: synthesis and applications
- Carbohydrate Chemistry and Synthesis
- Phosphodiesterase function and regulation
- biodegradable polymer synthesis and properties
- Retinoids in leukemia and cellular processes
- Pharmaceutical and Antibiotic Environmental Impacts
University of Genoa
2016-2025
Istituto Nazionale di Fisica Nucleare, Sezione di Genova
2015-2019
Istituto di Farmacologia Traslazionale
2015
University of Pisa
2005
University of Calabria
2005
The increasing emergence of multidrug resistant (MDR) pathogens causes difficult-to-treat infections, with long-term hospitalizations and high incidence death, thus representing a global public health problem. To manage MDR bacteria bugs, new antimicrobial strategies are necessary, their introduction in practice is daily challenge for scientists the field. An extensively studied approach to treat infections consists inducing levels reactive oxygen species (ROS) by several methods. Although...
Human neuroblastoma (NB), a pediatric tumor inclined to relapse, after an initial response therapy, usually develops resistance. Since several chemotherapeutics exert anticancer effect by increasing reactive oxygen species (ROS), NB cells overproduce antioxidant compounds becoming drugs-resistant. A strategy sensitize chemotherapy involves reducing their defenses and inducing ROS overproduction. Concerning this, although affected issues that limit clinical application,...
Water pollution from dyes is harmful to the environment, plants, animals, and humans one of most widespread problems afflicting people throughout world. Adsorption a widely used method remove contaminants derived textile industry, food colorants, printing, cosmetic manufacturing water. Here, aiming develop new low-cost up-scalable adsorbent materials for anionic dye remediation water decontamination by electrostatic interactions, two cationic resins (R1 R2) were prepared. In particular, they...
The increasing emergence of multidrug resistant (MDR) pathogens, due to antibiotics misuse, translates in obstinate infections, with high morbidity and high-cost hospitalizations. To oppose these MDR superbugs, new antimicrobial options are necessary. Although both quaternary ammonium (QASs) phosphonium salts (QPSs) possess effects, QPSs have been studied at lesser extent. Recently, we successfully reported on the bacteriostatic cytotoxic effects a triphenyl salt against isolates...
Organic ammonium and phosphonium salts exert excellent antimicrobial effects by interacting lethally with bacterial membranes. Particularly, quaternary lipids have demonstrated efficiency both as gene vectors antibacterial agents. Here, aiming at finding new devices belonging to classes, we prepared a water-soluble lipid (6) salt (1) designing synthetic path where 1 would be an intermediate achieve 6. All synthesized compounds were characterized Fourier-transform infrared spectroscopy...
Regenerative medicine is an interdisciplinary field aiming at restoring pathologically damaged tissues and whole organs by cell transplantation in combination with proper supporting scaffolds. Gelatine-based ones are very attractive due to their biocompatibility, rapid biodegradability, lack of immunogenicity. composite hydrogels, containing strengthening agents improve modest mechanical properties, have been demonstrated act as extracellular matrices (ECMs), thus playing a critical role...
A surface extract of the aerial parts Salvia chamaedryoides afforded 13 diterpenes (1–13), with seven compounds (1, 3, 4, 7–9, 12) described for first time. The structures new were established using 1D and 2D NMR spectroscopic methods, HRESIMS, ECD data. potential hypoglycemic effects crude extract, fractions, pure from S. investigated by inhibition α-glucosidase α-amylase enzymes. its fractions showed a moderate dose-dependent inhibition; exhibited differential inhibitory activity against...
Ellagic acid, a polyphenolic compound present in fruit and berries, has recently been the object of extensive research for its antioxidant activity, which might be useful prevention treatment cancer, cardiovascular pathologies, neurodegenerative disorders. Its protective role justifies numerous attempts to include it functional food preparations dietary supplements, not only limit unpleasant collateral effects chemotherapy. However, ellagic acid use as chemopreventive agent debated because...
Etoposide (ETO) is a cytotoxic drug that exerts its effect by increasing reactive oxygen species (ROS) production. Although ETO widely used, fast metabolism, poor solubility, systemic toxicity, and multi-drug resistance induction all limit administration dosage therapeutic efficiency. In order to address these issues, biodegradable dendrimer was prepared for entrapping protecting enhancing solubility effectiveness. The achieved complex with (CPX 5) showed the typical properties of...
Due to the rapid increase of antimicrobial resistance with ensuring therapeutic failures, purpose this study was identify novel synthetic molecules as alternatives conventional available, but presently ineffective antibiotics. Variously structured cationic dendrimers previously reported have provided promising outcomes. However, problem their cytotoxicity towards eukaryotic cells has not been completely overcome. We now investigated antibacterial activities three cytotoxic (G5Ds: G5H, G5K,...
To counteract the growing bacterial resistance, we previously reported remarkable antimicrobial activity of amino acid-conjugated cationic dendrimers (CDs) against several Gram-negative species, establishing that lysine was essential for their potency. In this paper, CDs conjugated with and arginine encapsulating ursolic oleanolic acids (UOACDs) were assumed to be excellent candidates developing new antibacterial agents, possibly active Gram-positive species. Indeed, both guanidine group two...
Water-soluble formulations of the pyrazole derivative 3-(4-chlorophenyl)-5-(4-nitrophenylamino)-1H-pyrazole-4-carbonitrile (CR232), which were proven to have in vitro antiproliferative effects on different cancer cell lines, prepared by two diverse nanotechnological approaches. Importantly, without using harmful organic solvents or additives potentially toxic humans, CR232 was firstly entrapped a biodegradable fifth-generation dendrimer containing lysine (G5K). CR232-G5K nanoparticles...