A5090833833- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Plant biochemistry and biosynthesis
- Essential Oils and Antimicrobial Activity
- Sesquiterpenes and Asteraceae Studies
- Phytochemistry and Bioactive Compounds
- Phytochemicals and Antioxidant Activities
- Traditional Chinese Medicine Analysis
- Biological Activity of Diterpenoids and Biflavonoids
- Phytochemical compounds biological activities
- Traditional and Medicinal Uses of Annonaceae
- Plant Toxicity and Pharmacological Properties
- Natural Antidiabetic Agents Studies
- Phytochemical Studies and Bioactivities
- Heat shock proteins research
- Marine Sponges and Natural Products
- Plant-based Medicinal Research
- Bioactive Natural Diterpenoids Research
- Fungal Biology and Applications
- Bioactive Compounds and Antitumor Agents
- Microbial Natural Products and Biosynthesis
- Phytochemistry and Bioactivity Studies
- Cynara cardunculus studies
- Bioactive natural compounds
- Plant chemical constituents analysis
University of Salerno
2016-2025
University of Palermo
2001-2025
University of Genoa
2004-2024
University of Pisa
2001-2019
Istituto di Farmacologia Traslazionale
2019
Institute for Macromolecular Studies
2012
Cluster in Biomedicine
2010
University of Trieste
2010
Al-Zaytoonah University of Jordan
2008-2009
Al-Azhar University
2008
A new cyclohexenone (1) and a caffeoyl ester derivative (2), together with the known compounds (−)-isolariciresinol 3-α-O-β-d-glucopyranoside (3), (+)-1-hydroxypinoresinol 1-O-β-d-glucopyranoside (4), isoacteoside (5), luteolin 4'-O-β-d-glucopyranoside (6), indole-3-carboxylic acid (7), were isolated from leaves of Bauhinia tarapotensis. The structures these determined by spectroscopic data analysis. antioxidant activities 1−7 measuring their free radical scavenging effects, using...
Extracellular vesicles (EVs) are promising tools for nanomedicine and nanobiotechnology. The purification of mammalian-derived EVs involves intensive processes, their therapeutic application raises multiple safety regulatory issues. Plants have the potential to serve as nonconventional sources therapeutically relevant EVs. In this context, we recently identified hairy roots (HRs) medicinal plants a novel biotechnological platform produce human health.
A quantitative study of the phenolic constituents wild and cultivated leaves Sclerocarya birrea(Anacardiaceae) was carried out by HPLC-UV/PDA LC-MS. Phytochemical analysis methanol extract plants led to isolation one new flavonol glycoside, quercetin 3-O-alpha-l-(5' '-galloyl)-arabinofuranoside (1), eight known compounds; two epicatechin derivatives were also isolated from same species. The antioxidant activity all compounds determined measuring free radical scavenging effects using Trolox...
As part of our screening anti-AIDS agents from medicinal plants, the MeOH extract aerial parts Ardisia japonica was tested, and it showed moderate in vitro anti-HIV activity. Reexamination to identify compounds responsible for activity revealed several known a new triterpenoid saponin (4) whose structure elucidation accomplished by 1H-1H correlation spectroscopy (COSY, HOHAHA, ROESY) 1H-13C heteronuclear (HETCOR) NMR experiments. All isolated were tested and, although none saponins active,...
A liquid chromatography-mass spectrometry (LC-MS)-based method was developed for the characterization of flavonoids from Sechium edule (Jacq) Swartz (Cucurbitaceae) edible organs, a plant cultivated since pre-Colombian times in Mexico where fruit is called chayote. Chayote used human consumption many countries; addition to fruits, stems, leaves and tuberous part roots are also eaten. Eight flavonoids, including three C-glycosyl five O-glycosyl flavones, were detected, characterized by...
Three new coumarins (1-3), a prenylated flavanone (4), and two iridoids (5 6), together with 17 known secondary metabolites, were isolated from the aerial parts of Arcytophyllum thymifolium. The structures compounds elucidated on basis their spectroscopic data. potential hypoglycemic properties evaluated by measuring α-amylase α-glucosidase inhibitory effects. iridoid asperulosidic acid (15) flavonoid rhamnetin (13) showed highest activities versus (IC50 = 69.4 ± 3.1 73.9 5.9 μM,...
Five new diterpenes (1-5) and a megastigmane derivative (6) were isolated from the aerial parts of Euphorbia laurifolia, along with several known compounds. Their structures elucidated by NMR, MS, ECD chemical methods. A proteomics drug affinity responsive target stability (DARTS) approach to investigate lathyrane diterpene 1, laurifolioside, on its putative cellular target(s) was performed. Clathrin heavy chain protein mainly involved in selective uptake proteins, viruses, other...
Introduction The development of agriculture in terms sustainability and low environmental impact is, at present, a great challenge, mainly underdeveloped marginal geographical areas. Salvia rosmarinus “Eretto Liguria” ecotype is widespread Liguria (Northwest Italy), farmers commonly use it by for cuttings marketing. In the present study, this was characterized comparison with other cultivars from same region Campania (Southern view to application registration processes designation protected...
The caffeoylquinic acids 3,4,5-tri-O-caffeoylquinic acid (1) and 4,5-di-O-caffeoylquinic (2), as well caffeic (4) synapoic (5) were isolated from the plant Securidaka longipedunculata (polygalaceae). 1 exhibited a greater selective inhibition of HIV replication than 2 which had an anti-HIV activity similar to that 3,4,5-tri-O-galloylquinic (3), Guiera senegalensis (combretaceae); 4 5 ineffective structurally related compound rosmarinic (6) only slight activity. Studies actions these...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConstituents of Eriobotrya japonica. A Study Their Antiviral PropertiesNunziatina De Tommasi, Francesco Simone, Cosimo Pizza, Naheed Mahmood, Patrick S. Moore, Cinzia Conti, Nicola Orsi, and Maria L. SteinCite this: J. Nat. Prod. 1992, 55, 8, 1067–1073Publication Date (Print):August 1, 1992Publication History Published online1 July 2004Published inissue 1 August...
Many severe human pathologies are related to alterations of the fine balance between histone acetylation and deacetylation; because not all such diseases involve hypoacetylation, but also hyperacetylation, compounds able enhance or repress activities acetyltransferases (HATs) could be promising therapeutic agents. We evaluated in vitro cell ability eleven natural polyisoprenylated benzophenone derivatives modulate HAT activity p300/CBP, an enzyme that plays a pivotal role variety cellular...
Diosmin is a flavonoid commonly found in citrus fruits, largely used as adjuvant treatment for circulatory disorders, including chronic venous insufficiency (CVI) and hemorrhoids. Following oral administration, diosmin not directly absorbed but must first be hydrolyzed into its aglycone, diosmetin, which then the systemic circulation. The aim of current cross-over clinical study was to assess pharmacokinetic profile µSmin® Plus, micronized complex standardized formulated with buffering agent...
The bioactive plant diterpene oridonin displays important pharmacological activities and is widely used in traditional Chinese medicine; however, its molecular mechanism of action still incompletely described. In vitro vivo data have demonstrated anti-tumor activity ability to interfere with several cell pathways; presently only the chaperone HSP70 has been identified as a direct potential target this compound. Here, using combination different proteomic approaches, innovative Cellular...
A surface extract of the aerial parts Salvia chamaedryoides afforded 13 diterpenes (1–13), with seven compounds (1, 3, 4, 7–9, 12) described for first time. The structures new were established using 1D and 2D NMR spectroscopic methods, HRESIMS, ECD data. potential hypoglycemic effects crude extract, fractions, pure from S. investigated by inhibition α-glucosidase α-amylase enzymes. its fractions showed a moderate dose-dependent inhibition; exhibited differential inhibitory activity against...