A5043587003- Phytochemicals and Antioxidant Activities
- Natural Antidiabetic Agents Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Plant Virus Research Studies
- Schizophrenia research and treatment
- Advanced Chemical Sensor Technologies
- Phytochemistry and Biological Activities
- Cynara cardunculus studies
- Food composition and properties
- Extracellular vesicles in disease
- Nicotinic Acetylcholine Receptors Study
- Essential Oils and Antimicrobial Activity
- Electrochemical Analysis and Applications
- Phytochemistry and Bioactive Compounds
- Nanoparticle-Based Drug Delivery
- Analytical Chemistry and Chromatography
- Garlic and Onion Studies
- Bipolar Disorder and Treatment
- Advanced oxidation water treatment
- Food Chemistry and Fat Analysis
- Ionic liquids properties and applications
- Meat and Animal Product Quality
- Protein Hydrolysis and Bioactive Peptides
- Medicinal Plant Research
- Fungal Plant Pathogen Control
University of Salerno
2020-2025
University of Palermo
2023-2025
University of Florence
2024
King's College London
2024
University of Turin
2015-2022
University of Messina
1999-2017
Torino e-district
2016
Extracellular vesicles (EVs) are promising tools for nanomedicine and nanobiotechnology. The purification of mammalian-derived EVs involves intensive processes, their therapeutic application raises multiple safety regulatory issues. Plants have the potential to serve as nonconventional sources therapeutically relevant EVs. In this context, we recently identified hairy roots (HRs) medicinal plants a novel biotechnological platform produce human health.
Imidazolium-based porous cationic polymers were synthesized using an innovative and facile approach, which takes advantage of the Debus–Radziszewski reaction to obtain meso-/microporous following click-chemistry principles.
Plant extracellular vesicles (EVs) concentrate and deliver different types of bioactive molecules in human cells are excellent candidates for a next-generation drug delivery system. However, the lack standard protocols plant EV production natural variations their biomolecular cargo pose serious limitation to use as therapeutics. To overcome these issues, we set up versatile standardized procedure purify EVs from hairy root (HR) cultures, biotechnological system, already successfully employed...
Calabrian
Aim: The purpose of this study was to estimate the effect sizes drug interactions on plasma clozapine concentrations, adjusting for potentially confounding factors such as smoking.
Bromelain is a mixture of cysteine endopeptidase usually extracted from pineapple juice and used for the treatment various human diseases in industrial applications. demand quickly increasing, its recovery residues appears to be sustainable waste management strategy. Pineapple core among most significant materials production canned richer bromelain than other residues. In this project, we compared enzymatic properties composition extracts either or pulp address bioactive core, thus...
Transcranial magnetic stimulation (TMS) combined with electromyography (EMG) has widely been used as a non-invasive brain tool to assess excitation/inhibition (E/I) balance. E/I imbalance is putative mechanism underlying symptoms in patients schizophrenia. Combined TMS-electroencephalography (TMS-EEG) provides detailed examination of cortical excitability the pathophysiology This study aimed investigate differences TMS-evoked potentials (TEPs), TMS-related spectral perturbations (TRSP) and...
This study evaluates the effects of fortifying bread with different concentrations (3%, 10%, and 30%) Matricaria chamomilla L. (MC) infusion powder, using aerial parts (stem, leaf, flower) plant. UPLC/MS-MS analysis MC powder EtOH ex-tract confirmed presence polyphenolic compounds, including flavonoids, contributing to enhanced antioxidant enzyme inhibitory properties. The physicochemical, antioxi-dant, sensory properties enriched breads were assessed. Hierarchical cluster revealed that 30%...
This study evaluates the effects of fortifying bread with different concentrations (3%, 10%, and 30%) Matricaria chamomilla L. (MC) infusion powder, derived from plant's aerial parts (stem, leaf, flower). UPLC/MS-MS analysis MC powder ethanolic extract confirmed presence polyphenolic compounds, including flavonoids, contributing to enhanced antioxidant enzyme inhibitory properties. The physicochemical, antioxidant, sensory properties enriched breads were assessed. Hierarchical cluster...
Agricultural by-products could be used as alternative raw materials in rabbit nutrition they have been found to highly nutritious and low cost feeding sources. The aim of this study was estimate the nutritive value potential use bilberry pomace (BP) for growing rabbits. A total 144 Grimaud rabbits (35 days old) were allotted four groups fed with a diet containing increasing level BP: BP0 (basal diet), BP5, BP10 BP15 0, 50, 100 150 g/kg respectively. Growth trial lasted 48 days; apparent...
Nicotine and cotinine are, respectively, alkaloids produced mainly by the Solanaceae plant family, especially tobacco, its most important human metabolite. These compounds are frequently found as contaminants in wastewater or landfill samples they could be used to evaluate pollution tobacco use. The aim of this study is improve knowledge about possible transformation pathways nicotine cotinine. This would help identification degradants using HPLC coupled with a high resolving power mass...
Hydroxycitrate (HCA), a main organic acid component of the fruit rind Garcinia cambogia, is natural citrate analog that can inhibit ATP lyase (ACLY) enzyme with consequent reduction inflammatory mediators (i.e., nitric oxide (NO), reactive oxygen species (ROS), and prostaglandin E2 (PGE2)) levels. Therefore, HCA has been proposed as novel means to prevent, treat, ameliorate conditions involving inflammation. However, presents low membrane permeability, large quantity required have biological...
(ToBRFV) is a new damaging plant virus of great interest from both an economical and research point view. ToBRFV transmitted by contact, remains infective for months, to-date, no resistant cultivars have been developed. Due to the relevance this virus, effective, sustainable, operator-safe antiviral agents are needed. Thus, 4-hydroxybenzoic acid was identified as main product alkaline autoxidation at high temperature methanolic extract leaves
Plants of genus Cichorium (Asteraceae) can be used as vegetables with higher nutritional value and medicinal plants. This has beneficial properties owing to the presence a number specialized metabolites such alkaloids, sesquiterpene lactones, coumarins, unsaturated fatty acids, flavonoids, saponins, tannins. endivia L., known escarole, achieved common food status due its nutritionary value, bitter taste, healthy components, is eaten cooked or raw in salads. Presently, wastes derived from...
The purpose of this study was to develop a simple, direct, multiresidue highly specific procedure evaluate the possible surface contamination selected antineoplastic drugs in several hospital environment sites by using wipe test sampling. 5‐fluorouracil (5‐FU), carboplatin (C‐Pt), cyclophosphamide (CYC), cytarabine (CYT), doxorubicin (DOX), gemcitabine (GEM), ifosfamide (IFO), methotrexate (MET), and mitomycin C (MIT) belong very different chemical classes but show good ionization properties...
Phenolic compounds of red wine powder (RWP) extracted from the Italian Aglianico del Vulture have been investigated for potential immunomodulatory and anti‐inflammatory capacity on human macrophages. These reduce secretion IL‐1 β , IL‐6, TNF‐ α proinflammatory cytokines increase release IL‐10 cytokine induced by lipopolysaccharide (LPS). In addition, RWP restores Annexin A1 levels, thus involving activation proresolutive pathways. Noteworthy, lowers NF‐ κ B protein promoter activity, nuclear...
A comparative quali-quantitative study of the peel extracts eight Punica granatum cultivars obtained from underexploited areas South Italy was carried out in order to valorize them as health-promoting by-products. The results showed that all samples possessed 45 ellagitannins, consisting mainly polyhydroxyphenoyls; 10 flavonoids, belonging flavonol, flavone, and catechin classes; 2 anthocyanins. most representative compounds underwent quantification through a LC-MS/MS multiple reaction...
Interesterification is an industrial transformation process aiming to change the physico-chemical properties of vegetable oils by redistributing fatty acid position within original constituent triglycerides. In confectionery industry, controlling formation degree positional isomers important in order obtain fats with desired properties. Silver ion HPLC (High Performance Liquid Chromatography) analytical technique usually adopted separate triglycerides (TAGs) having different unsaturation...
In developing countries, crop deterioration is mainly caused by inappropriate storage conditions that promote insect infestation. Synthetic pesticides are associated with serious adverse effects on humans and the environment. Thus, finding alternative “green” insecticides a very pressing need. Calotropis procera (Aiton) Dryand (Apocynaceae) growing in Saudi Arabia was selected for this purpose. LC-MS/MS analysis applied to investigate metabolic composition of different C. extracts....