A5082606573- Advanced Chemical Sensor Technologies
- Mass Spectrometry Techniques and Applications
- Odor and Emission Control Technologies
- Toxic Organic Pollutants Impact
- Pharmaceutical and Antibiotic Environmental Impacts
- Analytical Chemistry and Chromatography
- Indoor Air Quality and Microbial Exposure
- Analytical chemistry methods development
- Effects and risks of endocrine disrupting chemicals
- Ion-surface interactions and analysis
- Cancer, Lipids, and Metabolism
- Air Quality and Health Impacts
- Cancer Treatment and Pharmacology
- Air Quality Monitoring and Forecasting
- Cancer, Hypoxia, and Metabolism
- Smoking Behavior and Cessation
- Pesticide Residue Analysis and Safety
- Ovarian cancer diagnosis and treatment
- Advanced Proteomics Techniques and Applications
- Angiogenesis and VEGF in Cancer
- Water Treatment and Disinfection
- Metabolomics and Mass Spectrometry Studies
- Vehicle emissions and performance
- Environmental Toxicology and Ecotoxicology
- Olfactory and Sensory Function Studies
Mario Negri Institute for Pharmacological Research
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2024
Università Campus Bio-Medico
2023
Campus Bio Medico University Hospital
2022
Mylan (Switzerland)
2015
Milano University Press
2015
Dayton T. Brown (United States)
1999
Long Island University
1999
Ospedale San Paolo
1993
University of Milan
1993
<h3>Objective</h3> We propose a novel approach for measuring tobacco use in community through the chemical analysis of nicotine metabolites urban wastewater. It offers frequent monitoring and ‘real-time’, ‘evidence-based’ estimates consumption which may complement epidemiological surveillance systems normally repeated only every few years. <h3>Methods</h3> Two urinary nicotine, namely cotinine <i>trans</i>-3′-hydroxycotinine, were selected as biomarkers During smoking, known amount is...
MR1T cells are a recently found class of T that recognize antigens presented by the major histocompatibility complex-I–related molecule MR1 in absence microbial infection. The nature self-antigens stimulate remains unclear, hampering our understanding their physiological role and therapeutic potential. By combining genetic, pharmacological, biochemical approaches, we carbonyl stress changes nucleobase metabolism target promote cell activation. Stimulatory compounds formed adducts nucleobases...
Abstract Mass Spectrometry Imaging (MSI) is a widespread technique used to qualitatively describe in two dimensions the distribution of endogenous or exogenous compounds within tissue sections. Absolute quantification drugs using MSI recent challenge that just last years has started be addressed. Starting from dimensional protocol, we developed three-dimensional pipeline study drug penetration tumors and develop new method by MALDI MSI. Paclitaxel concentration different were measured 3D...
Abstract The penetration of anticancer drugs in solid tumors is important to ensure the therapeutic effect, so methods are needed understand drug distribution different parts tumor. Mass spectrometry imaging (MSI) has great potential this field visualize organs and tumor tissues with good spatial resolution superior specificity. We present an accurate reproducible method investigate variation tumors. was applied study paclitaxel three ovarian cancer models histopathological characteristics...
Abstract Despite its high demand, the seafood processing industry grapples with a substantial challenge: generating significant waste, encompassing edible and inedible by-products. This leads to considerable financial losses raises socioecological concerns regarding managing disposing of such waste. Urgently addressing this issue, implementing sustainable preservation methods becomes crucial. study provides comprehensive summary chemical physical approaches proposed in literature prevent...
The antitumor activity of angiogenesis inhibitors is reinforced in combination with chemotherapy. It debated whether this potentiation related to a better drug delivery the tumor due antiangiogenic effects on vessel phenotype and functionality. We addressed question by combining bevacizumab paclitaxel A2780-1A9 ovarian carcinoma HT-29 colon transplanted ectopically subcutis nude mice IGROV1 orthotopically bursa mouse ovary. Paclitaxel concentrations together its distribution MALDI mass...
A sensitive, simple and reproducible protocol for nanoparticle-assisted laser desorption/ionization mass spectrometry imaging technique is described. The use of commercially available TiO2 nanoparticles abolishes heterogeneous crystallization, matrix background interferences enhances signal detection, especially in the low range. Molecular image normalization was based on internal standard deposition tissues, allowing direct comparison drug penetration distribution between different organs...
More than a decade after electronic cigarettes (e-cigarette) hit the European market, we are still debating whether they may help or hinder tobacco control. It is therefore useful to explore potential net effect of e-cigarette use in general population.We annually conduct face-to-face survey on smoking Italy representative sample population aged 15 years over (52.4 million). A total 406 subjects were interviewed 2014-2018. We investigated consequences using e-cigarettes behaviour among ever...
Scarce drug penetration in solid tumours is one of the possible causes limited efficacy chemotherapy and related to altered tumour microenvironment. The abnormal extracellular matrix (ECM) together with blood lymphatic vessels, reactive stroma inflammation all affect uptake, distribution anticancer drugs.We investigated effect PEGylated recombinant human hyaluronidase PH20 (PEGPH20) pre-treatment degrading hyaluronan (hyaluronic acid; HA), main components ECM, improve delivery antitumor...
Abstract Background The Observed Individual Means (OIM) methodology, based on the non-parametric bootstrap, is usually employed to perform basic probabilistic dietary chronic exposure assessment, and assumes independence identical distribution of occurrence data within food category. However, this assumption may not be valid if several expected distributions can a priori identified Moreover, OIM each analysed sample equally contribute mean occurrence, as information about relevance item...