A5077085798- Pharmaceutical and Antibiotic Environmental Impacts
- Analytical chemistry methods development
- Forensic Toxicology and Drug Analysis
- Water Treatment and Disinfection
- Pesticide and Herbicide Environmental Studies
- Antibiotics Pharmacokinetics and Efficacy
- Effects and risks of endocrine disrupting chemicals
- Psychedelics and Drug Studies
- Toxic Organic Pollutants Impact
- SARS-CoV-2 detection and testing
- Diet and metabolism studies
- Cannabis and Cannabinoid Research
- Pharmacological Effects and Assays
- Biosensors and Analytical Detection
- Pesticide Exposure and Toxicity
- Environmental Toxicology and Ecotoxicology
- Environmental Chemistry and Analysis
- Opioid Use Disorder Treatment
- Environmental Justice and Health Disparities
- Air Quality and Health Impacts
- Drug Transport and Resistance Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Nutritional Studies and Diet
- Advanced Chemical Sensor Technologies
- Pesticide Residue Analysis and Safety
Mario Negri Institute for Pharmacological Research
2014-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2023
Norges Røde Kors
2022
Mylan (Switzerland)
2021
Norwegian Institute for Water Research
2020
Google (United States)
2009
University of Insubria
2003-2006
University of Naples Federico II
2004
University Medical Center Freiburg
2001-2004
University of Milan
1988-1993
A listing of “priority pharmaceuticals” for human use in Italy resulted the selection 26 pharmaceuticals, belonging to 11 therapeutic classes. They were analyzed by liquid chromatography−tandem mass spectrometry, their occurrence was assessed six sewage treatment plants (STPs), and loads removal rates (RR) studied. Total ranged from 1.5 4.5 g/day/1000 inhabitants influents 1.0 3.0 effluents. RR STPs mostly lower than 40%. Pharmaceuticals could be divided into three groups according behavior...
A survey was done in the river Po (Italy) to check for therapeutic drugs environment. number of pharmaceuticals were selected analysis on basis high consumption and excretion as parent compound humans. Eight sampling stations along rivers Lambro made it possible plot patterns contamination a highly populated region with large animal farms. Atenolol, lincomycin, erythromycin, clarithromycin, bezafibrate, furosemide present at all sites, other found only some. Concentrations ranged from 0.1...
Abstract Background Cocaine use seems to be increasing in some urban areas worldwide, but it is not straightforward determine the real extent of this phenomenon. Trends drug abuse are currently estimated indirectly, mainly by large-scale social, medical, and crime statistics that may biased or too generic. We thus tested a more direct approach based on 'field' evidence cocaine general population. Methods its main urinary metabolite (benzoylecgonine, BE) were measured mass spectrometry water...
The social and medical problems of drug abuse are a matter increasing global concern. To tackle in changing scenarios, international agencies need fresh methods to monitor trends patterns illicit consumption.We tested sewage epidemiology approach, using levels excreted residues wastewater, collective use the major drugs near real time.Selected target derived from cocaine, opiates, cannabis, amphetamines were measured by mass spectrometry wastewater collected at treatment plants Milan...
The potential risk associated with the presence of low levels pharmaceuticals in aquatic environments is currently under debate. In this study we investigated effects 13 drugs merged to mimic both association and concentration (ng/L) profiles detected environment. mixture comprised atenolol, bezafibrate, carbamazepine, cyclophosphamide, ciprofloxacin, furosemide, hydrochlorothiazide, ibuprofen, lincomycin, ofloxacin, ranitidine, salbutamol, sulfamethoxazole. At environmental exposure levels,...
Residues of illicit drugs and their metabolites that are excreted by humans may flow into through wastewater treatment plants. The aim this study was to develop a method for the determination cocaine, amphetamines, morphine, cannabinoids, methadone, some in wastewater. Composite 24-h samples from urban plants were enriched with deuterated internal standards before solid-phase extraction. High-pressure liquid chromatography tandem mass spectrometry multiple reaction monitoring used...
The aim of this study was to integrally address the uncertainty associated with all steps used estimate community drug consumption through chemical analysis sewage biomarkers illicit drugs. Uncertainty has been evaluated for sampling, analysis, stability in sewage, back-calculation use (specific case cocaine), and estimation population size a catchment using data collected from recent Europe-wide investigation available literature. quality sampling protocols analytical measurements by...
Abstract Background and aims Wastewater‐based epidemiology is an additional indicator of drug use that gaining reliability to complement the current established panel indicators. The this study were to: (i) assess spatial temporal trends population‐normalized mass loads benzoylecgonine, amphetamine, methamphetamine 3,4‐methylenedioxymethamphetamine (MDMA) in raw wastewater over 7 years (2011–17); (ii) address overall by estimating average number combined doses consumed per day each city;...
The chemical pollution crisis severely threatens human and environmental health globally. To tackle this challenge the establishment of an overarching international science-policy body has recently been suggested. We strongly support initiative based on awareness that humanity already likely left safe operating space within planetary boundaries for novel entities including pollution. Immediate action is essential needs to be informed by sound scientific knowledge data compiled critically...
Amoxicillin is a widely used penicillin-like antibiotic, and due to its presence in several effluents of ItalianSTPs, environmental fate along with toxicity toward simple organisms have been investigated model conditions. The present study shows that under abiotic conditions both hydrolysis direct photolysis could be responsible for the transformation removal amoxicillin aquatic environment, especially slightly basic media. Quantum yields solar calculated kinetic constants half-life times....
With the goal of assessing environmental risk pharmaceuticals, we have previously observed that a mixture 13 different drugs at environmentally relevant concentrations had adverse consequences on human and zebra fish cells in vitro. Here aimed to identify both main interaction effects within same pharmaceuticals. We studied vitro cytotoxicity Escherichia coli, embryonic HEK293, estrogen-responsive OVCAR3 tumor using fractional-factorial experimental design. Our approach identified subset...
<h3>Objective</h3> We propose a novel approach for measuring tobacco use in community through the chemical analysis of nicotine metabolites urban wastewater. It offers frequent monitoring and ‘real-time’, ‘evidence-based’ estimates consumption which may complement epidemiological surveillance systems normally repeated only every few years. <h3>Methods</h3> Two urinary nicotine, namely cotinine <i>trans</i>-3′-hydroxycotinine, were selected as biomarkers During smoking, known amount is...