A5044474920- Pharmaceutical and Antibiotic Environmental Impacts
- Analytical chemistry methods development
- Analytical Chemistry and Chromatography
- Mass Spectrometry Techniques and Applications
- Water Treatment and Disinfection
- Advanced Chemical Sensor Technologies
- Metabolomics and Mass Spectrometry Studies
- Environmental Toxicology and Ecotoxicology
- Environmental Chemistry and Analysis
- Forensic Fingerprint Detection Methods
- Chemical Analysis and Environmental Impact
- Water Quality and Pollution Assessment
- Analytical Chemistry and Sensors
- Microfluidic and Capillary Electrophoresis Applications
- Computational Drug Discovery Methods
- Forensic Toxicology and Drug Analysis
- Air Quality and Health Impacts
- Forensic and Genetic Research
- Healthcare and Environmental Waste Management
- Health, Environment, Cognitive Aging
- Pesticide Residue Analysis and Safety
- Toxic Organic Pollutants Impact
- Biosensors and Analytical Detection
- Water Quality Monitoring and Analysis
- Antibiotics Pharmacokinetics and Efficacy
Imperial College London
2020-2025
King's College London
2015-2025
MRC Centre for Environment and Health
2020-2025
University of Amsterdam
2023-2024
NIHR Imperial Biomedical Research Centre
2024
Institute for Molecular Science
2023-2024
UK Health Security Agency
2024
Medical Research Council
2021
Transnational Press London
2020
Institute of Forensic Science
2019
The ability to estimate the age of donor from recovered biological material at a crime scene can be substantial value in forensic investigations. Aging complex and is associated with various molecular modifications cells that accumulate over person's lifetime including epigenetic patterns. aim this study was use age-specific DNA methylation patterns generate an accurate model for prediction chronological using data whole blood. In total, 45 age-associated CpG sites were selected based on...
Abstract Background and aims Wastewater‐based epidemiology is an additional indicator of drug use that gaining reliability to complement the current established panel indicators. The this study were to: (i) assess spatial temporal trends population‐normalized mass loads benzoylecgonine, amphetamine, methamphetamine 3,4‐methylenedioxymethamphetamine (MDMA) in raw wastewater over 7 years (2011–17); (ii) address overall by estimating average number combined doses consumed per day each city;...
Multiple classes of environmental contaminants have been found in aquatic environments, globally. Understanding internalised concentrations the organism could further improve risk assessment process. The present study is concerned with determination several contaminant (107 compounds) Gammarus pulex collected from 15 sites covering 5 river catchments across Suffolk, UK. Quantitative method performance was acceptable for 67 compounds including pharmaceuticals, pesticides, illicit drugs and...
Quantitative measurement of drug consumption biomarkers in wastewater can provide objective information on community use patterns and trends. This study presents the alcohol 20 cities across 11 countries through wastewater-based epidemiology (WBE), reports application these data for risk assessment a population scale using margin exposure (MOE) approach. Raw 24-h composite samples were collected over one-week period from following common protocol. For each sample specific stable biomarker,...
A rapid quantitative method for 135 contaminants of emerging concern (CECs) in untreated wastewater enabled with direct injection liquid chromatography-tandem mass spectrometry is presented. All compounds were analysed within 5 min on a short biphenyl cartridge using only 10 μL filtered sample per injection. Up to 76 monitored simultaneously during the gradient (including mostly two transitions compound and stable isotope-labelled analogues) while yielding >10 data points peak. Evaluation...
Despite being a developed country in the European Union (EU), knowledge of nature and extent contamination water bodies with contaminants emerging concern (CECs) Ireland is limited. In this study, >140 CECs including pharmaceuticals, pesticides personal care products were monitored monthly samples wastewater treatment plant (WWTP) influent, effluent receiving surface waters at both an urban rural location (72 total) over 12-month period 2018-2019. total, 58 detected, several EU Water...
A comprehensive analytical investigation of the sorption behaviour a large selection over-the-counter, prescribed pharmaceuticals and illicit drugs to agricultural soils freeze-dried digested sludges is presented. Batch experiments were carried out identify which compounds could potentially concentrate in as result biosolid enrichment. Analysis aqueous samples was directly using liquid chromatography-tandem mass spectrometry (LC-MS/MS). For solids analysis, combined pressurised extraction...
An analytical method to determine a selection of 27 frequently prescribed and consumed pharmaceuticals in biosolid enriched soils digested sludges is presented. Using combination pressurized liquid extraction, solid phase extraction chromatography with tandem mass spectrometry, it was possible detect all analytes each sample type at the low-sub ng g(-1) level. Solid efficiencies were compared for 6 different sorbent types found that Waters Oasis HLB cartridges offered enhanced selectivities...
The occurrence of pharmaceutical and illicit drug residues potentially arising from combined sewer overflows (CSOs) in the Central London portion Thames Estuary is presented. Approximately 39 million tonnes untreated sewage enter River at 57 CSO points annually. Differential analysis influents effluents a major wastewater treatment plant identified seven potential drug-related markers based on removal rates. Three were present influent concentrations >1 μg L-1 (caffeine, cocaine...
The application of machine learning has recently gained interest from ecotoxicological fields for its ability to model and predict chemical and/or biological processes, such as the prediction bioconcentration. However, comparison different models bioconcentration in invertebrates not been previously evaluated. A 24 linear is presented herein fish important factors that influenced accumulation identified. R2 root mean square error (RMSE) test data (n = 110 cases) ranged 0.23-0.73 0.34-1.20,...
The first comprehensive assessment of 34 solid phase extraction sorbents is presented for organic explosive residues in wastewater prior to analysis with liquid chromatography-high resolution accurate mass spectrometry (LC-HRMS). A total 18 explosives were selected including nitramines, nitrate esters, nitroaromatics and peroxides. Three polymeric divinylbenzene-based found be most suitable one co-polymerised n-vinyl pyrrolidone offered satisfactory recoveries 14 compounds fortified...
The SARS-CoV-2 pandemic had huge impacts on global urban populations, activity and health, yet little is known about attendant consequences for river ecosystems. We detected significant changes in occurrence risks from contaminants of emerging concern (CECs) waterways across Greater London (UK) during the pandemic. were able to rapidly identify monitor large numbers CECs n = 390 samples 2019-2021 using novel direct-injection liquid chromatography-mass spectrometry methods scalable targeted...