A5050454591- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Economics and Policy
- Pharmaceutical industry and healthcare
- Mental Health and Patient Involvement
- Biomedical Ethics and Regulation
- Circadian rhythm and melatonin
- Telemedicine and Telehealth Implementation
- Pharmaceutical studies and practices
- Healthcare Policy and Management
- Reproductive Physiology in Livestock
- Neuroendocrine regulation and behavior
- MRI in cancer diagnosis
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Blood donation and transfusion practices
- Social Media in Health Education
- Mobile Health and mHealth Applications
- Biotechnology and Related Fields
- Pharmaceutical Quality and Counterfeiting
- Reproductive Biology and Fertility
- Patient-Provider Communication in Healthcare
- Health Policy Implementation Science
- Ethics in Clinical Research
- Monoclonal and Polyclonal Antibodies Research
- Primary Care and Health Outcomes
University of Utah
2008-2024
Capital District Health Authority
2024
All India Institute of Hygiene and Public Health
2022
Royal Australasian College of Surgeons
2017
The University of Adelaide
2017
New York University Press
2017
Cambridge University Press
2017
Novartis (Switzerland)
1994-1995
Philipps University of Marburg
1985-1988
The University of Texas Health Science Center at San Antonio
1983-1986
Abstract This study details the procedures involved in measuring a number of components indole metabolism within pineal gland. Tryptophan, 5‐hydroxytryptophan, serotonin, N‐acetylserotonin, melatonin, 5‐hydroxyindoleacetic acid, N‐acetyltransferase (NAT) activity, and hydroxyindole‐O‐methyltransferase activity were measured by combination three techniques, which included microassays, radioimmunoassay, high‐performance liquid chromatography. Determination melatonin synthetic pathway same...
The ruminant corpus luteum synthesizes and secretes oxytocin, but little is known of the regulation these processes in ovary. In present work we describe a method for preparation cells from early bovine (1-5 days postovulation) their maintenance serum-free culture. release oxytocin progesterone was increased by addition insulin or insulin-like growth factor I (IGF-I), not IGF-II. Hormone (measured between 60 84 h culture) approximately 5-fold (oxytocin) 2.5-fold (progesterone) maximally...
Although patient preferences have been studied broadly for marketed products or around the time of submission to authorities and launch, preference studies rarely used during early drug development phases. In this paper, we formulate three hypotheses supporting use in product development: (1) integration perspective into process from phase 1 onwards will result healthcare solutions with outcomes that best address patients' needs; (2) a structured build patient-based evidence involving...
Abstract Background Patient blood management (PBM) describes a set of evidence-based practices to optimize medical and surgical patient outcomes by clinically managing preserving patient’s own blood. This concepts aims detect treat anemia, minimize the risk for loss need replacement each through coordinated multidisciplinary care process. In combination with loss, anemia is main driver transfusion all three are independent factors adverse including morbidity mortality. Evidence demonstrates...
Although there is increased awareness of patient and public involvement (PPI) among health technology assessment (HTA) organizations, evaluations PPI initiatives are relatively scarce. Our objective as members Health Technology Assessment International's (HTAi's) Patient Citizen Involvement Group (PCIG) was to advance understanding the range evaluation strategies adopted by HTA organizations their potential usefulness.In March 2016, a survey sent fifty-four through International Network...
Rapidly evolving socioeconomic and technological trends make it challenging to improve access, effectiveness efficiency in the use of pharmaceuticals. This paper identifies systematically classifies prevailing pharmaceutical policies worldwide relation a country's income status. A literature search was undertaken identify taxonomize worldwide. Countries that apply those do not were then grouped by Pharmaceutical are linked socioeconomics. Developed countries have universal coverage control...
Oxytocin is a major peptide product of the ruminant corpus luteum, and release oxytocin from serumfree cultures bovine granulosa cells stimulated by insulin insulin-like growth factor-I (IGF-I). Here we have assessed effects IGF-I on gene expression in dependence these developmental status cells. When individual follicles were cultured, estradiol concentration follicular fluid was highly correlated with insulin-stimulated release. Subsequently, pooled selected basis content, two subsets...
In Kuwait, the government is planning to improve specifications for purchase of medicine and tendering system intending slow growth expenditure sustainability healthcare system. Multiple Criteria Decision Analysis (MCDA) a method which can help assess multiple sometimes conflicting criteria in evaluation available alternatives. The objective this initiative was develop collaboratively MCDA tool locally relevant, could be used use performance indicators purchasing off-patent...
Djungarian hamsters kept in long photoperiod (16:8 L:D) were injected daily at 0800, 1200, or 1600 with 25 μg of melatonin. During 90 days treatment, body weight and fur coloration checked weekly intervals, the end treatment reproductive status their thermoregulatory properties (cold limit, maximum heat production, nonshivering thermogenesis, cytochrome oxidase activity brown adipose tissue) measured. Hamsters changed from summer to winter regard all functions investigated responding...
Objective: The effectiveness of treatment decisions and economic outcomes using gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging (Gd-EOB-DTPA-MRI) were compared with extracellular contrast media-enhanced MRI (ECCM-MRI) multi-detector computed tomography (MDCT) as initial procedures in patients suspected hepatocellular carcinoma (HCC) South Korea Thailand. Methods: A decision-tree model simulated the clinical pathway for HCC from first procedure...
Limited data exists in China on the comparative cost of gadolinium ethoxybenzyl diethylenetriamine magnetic resonance imaging (Gd-EOB-DTPA-MRI) with other techniques. This study compared total Gd-EOB-DTPA-MRI multidetector computed tomography (MDCT) and extracellular contrast media–enhanced MRI (ECCM-MRI) as initial procedures patients suspected hepatocellular carcinoma (HCC). We developed a decision-tree model basis Chinese clinical guidelines for HCC, which was validated by experts from...
Abstract Objectives Evaluating the impact of patient involvement in health technology assessments (HTA) may help improve practices and avoid ineffective activities. Evaluation, however, continues to be infrequent, inconsistent, often only relates process quantity or quality. The Patient Citizen Involvement HTA Interest Group (PCIG) within Health Technology Assessment International set out contextualize this support evaluation. Methods Given lack established methodology measure impact, team...
Plasma thyroid hormone concentrations in male and female Syrian hamsters were evaluated five experiments after two pineal indoles, melatonin (MEL) 5-methoxytryptamine (5-MT), administered as chronic s.c. implants and/or daily afternoon injections. Circulating of thyroxine (T4), ordinarily maintained by the long photoperiod (LD 14:10), inhibited injections 25 µg MEL but not 5-MT (experiment 1) 2) hamsters. The suppressive effect on T4 concentration was prevented both sexes a beeswax pellet...
Pharmaceutical research and development (R&D) is costly only a minority of patients can access innovative medicines due to affordability constraints. Value-added (VAMs) offer potential benefits at significantly lower R&D costs.VAMs may address different health care needs problems, including off-label use medicines, poor patient adherence, problems related polypharmacy, need for home and/or personalized services. However, several barriers prevent societies from maximizing the incremental...