A5061165667- COVID-19 Clinical Research Studies
- Hematopoietic Stem Cell Transplantation
- Hepatitis C virus research
- Mesenchymal stem cell research
- SARS-CoV-2 and COVID-19 Research
- Hepatitis B Virus Studies
- Renal Transplantation Outcomes and Treatments
- Blood donation and transfusion practices
- Acute Lymphoblastic Leukemia research
- Organ Transplantation Techniques and Outcomes
- Cancer Cells and Metastasis
- COVID-19 Impact on Reproduction
- Blood transfusion and management
- Hematological disorders and diagnostics
- COVID-19 epidemiological studies
- Acute Myeloid Leukemia Research
- Organ Donation and Transplantation
- CAR-T cell therapy research
- Transplantation: Methods and Outcomes
- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Liver Disease Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Polyomavirus and related diseases
- Complement system in diseases
King Faisal Specialist Hospital & Research Centre
2012-2025
King Abdulaziz Hospital
2023
King Fahd Medical City
2020
King Fahad Specialist Hospital
2020
King Saud bin Abdulaziz University for Health Sciences
2020
King Abdulaziz Medical City
2020
King Abdullah International Medical Research Center
2020
Imam Abdulrahman Bin Faisal University
2020
Qassim University
2017
American Association of Blood Banks
2009
Abstract Hepatitis B virus (HBV) is the major causative agent of chronic liver complications including cirrhosis and hepatocellular carcinoma (HCC). Individuals infected with HBV show a wide spectrum disease manifestations ranging from asymptomatic carriers to HCC. TLR3 part innate immune system that recognizes double‐stranded RNA (dsRNA) provides early response exogenous antigens. The genetic polymorphisms such as single nucleotide (SNPs) in could be considered factors for susceptibility...
Abstract Background Patient blood management (PBM) describes a set of evidence-based practices to optimize medical and surgical patient outcomes by clinically managing preserving patient’s own blood. This concepts aims detect treat anemia, minimize the risk for loss need replacement each through coordinated multidisciplinary care process. In combination with loss, anemia is main driver transfusion all three are independent factors adverse including morbidity mortality. Evidence demonstrates...
Background/Objectives: We aimed to identify the molecular signatures of primitive CD34+ and CD34- hematopoietic stem/progenitor cell (HSC/HPC) subsets in cord blood bone marrow samples. Methods: HSC/HPC from were characterized using flow cytometry, real-time PCR, proteomic analysis evaluate their phenotypic profiles. Results: Our findings revealed a significantly higher percentage Lin-CD34-CD38Low/- (-/-) cells than Lin-CD34+CD38Low/- (+/-) blood. Aldehyde dehydrogenase levels lower cells....
Abstract Background Mesenchymal stem cells have properties that make them amenable to therapeutic use. However, the acceptance of mesenchymal in clinical practice requires standardized techniques for their specific isolation. To date, there are no conclusive marker (s) exclusive isolation cells. Our aim was identify markers differentially expressed between cell and non-stem cultures. We compared contrasted phenotype tissue cultures which rich rare. By initially assessing differentiation, we...
Abstract Background and objectives Cytokine release syndrome in COVID‐19 is due to a pathological inflammatory response of raised cytokines. Removal these cytokines by therapeutic plasma exchange (TPE) prior end‐organ damage may improve clinical outcomes. This manuscript intended serve as preliminary guidance document for application TPE patients with severe COVID‐19. Material methods The available literature pertaining the role treatment was reviewed guide optimal management. It included...
To present the interim findings from a national study investigating safety and efficacy of convalescent plasma (CP) containing detectable IgG antibodies as treatment strategy for severe coronavirus disease 2019 (COVID-19).An open label, two-arm, phase-II clinical trial conducted across 22 hospitals Saudi Arabia. The intervention group included 40 adults (aged ≥18 years) with confirmed COVID-19 control 124 patients matched using propensity score age, gender, intubation status, history...
We estimated HLA allele and haplotype frequencies of the Saudi Arabian population from a sample 45,457 registered stem cell donors. The most frequent alleles were A*02:01g (18.5%), C*06:02g (16.1%), B*51:01g (14.1%), DRB1*07:01g (16.2%), DQB1*02:01g (30.5%), DPB1*04:01g (33.6%). 5-locus haplotypes A*02:05g~C*06:02g~B*50:01g~DRB1*07:01g~DQB1*02:01g (1.73%), A*02:01g~C*06:02g~B*50:01g~DRB1*07:01g~DQB1*02:01g (1.66%), A*26:01g~C*07:02g~B*08:01g~DRB1*03:01g~DQB1*02:01g (1.38%). Furthermore, we...
The COVID-19 pandemic is expected to cause significant morbidity and mortality. development of an effective vaccine will take several months become available, its affordability unpredictable. Transfusion convalescent plasma (CP) may provide passive immunity. Based on initial data from China, a group hematologists, infectious disease specialists, intensivists drafted this protocol in March 2020.The aim study test the feasibility, safety, efficacy CP treating patients with across Saudi...
Besides the host immune response, genetic and environmental factors play crucial roles in manifestation of hepatitis B virus (HBV) infection. "Regulated on activation normal T-cell expressed secreted" factor (RANTES) plays a vital role CD4(+), CD8(+) T-lymphocyte dendritic cell proliferation inflammation. Single nucleotide polymorphisms (SNPs) RANTES gene are associated with several viral non-viral diseases. Association studies have invariably indicated lack association between SNPs HBV...
Background/Aim. This study aims to investigate whether the SNPs of CXCR1 gene, could predict likelihood viral persistence and/or disease progression. Material and methods. We investigated association two different (rs2234671, rs142978743) in 598 normal healthy controls 662 HBV patients from a Saudi ethnic population. The were categorized into inactive carriers (n = 428), active 162), cirrhosis 54) Cirrhosis-HCC 18) sub-groups. Genetic variants determined by polymerase chain reaction...
<br>Although the outcomes of ABO-incompatible (ABOi) kidney transplant recipients are quite favorable, these patients at increased risk early antibody-mediated rejection (AMR) and graft loss. Some studies have also shown high mortality in ABOi group mainly due to infections. The AMR rates been reported anywhere from <10% >50% literature. transplants Saudi population not known. In this study, we aimed determine patient survival population. We included all adult who underwent transplantation...
The Wilms tumor antigen 1 (WT1) is over-expressed in human leukemias, making it an attractive target for immunotherapy. Most WT1-specific Cytotoxic T Lymphocytes (CTLs) described so far displayed low avidity, limiting its function. To improve the immunogenicity of CTL epitopes, we replaced first-amino-acid two known immunogenic WT1-peptides (126 and 187) with a tyrosine. This modification enhances 126Y analogue-binding ability, triggers significant number IFN-γ-producing cells (P = 0.0003),...
Abstract: Objective: Previously, deletion 6p23 was generally reported in therapy‐related secondary acute myeloid leukemia (AML) as part of complex karyotypes. In this report, we present two young adult patients with de novo AML‐M2 and a terminal sole primary abnormality, confirmed by chromosome 6 specific subtelomeric probes. Methods: Two female 35 20 yr age presented anemia, but no bleeding, infections, lymphadenopathy or organomegaly. Morphological, immunophenotyping, fluorescent situ...
Abstract Background Physicians may be an important source of blood donations as they are more likely to familiar with the importance donating and donation process. The aim this study is report physicians' knowledge, attitudes, practices towards voluntary non‐voluntary donations. Study Design Methods This was a cross‐sectional conducted at King Faisal Specialist Hospital Research Centre (KFSH&RC), Saudi Arabia. One‐hundred‐and‐sixteen physicians dentists responded online structured...
The success of orthotopic liver transplantation as a life-saving treatment has led to new indications and greater competition for organ grafts. Pediatric patients with acute liver-related crises can benefit from transplantation, but availability in the limited time be major obstacle. Crossing ABO blood group barriers could increase organs available such patients.From November 2010 June 2015, 176 children aged 0.2-to18 y were transplanted King Faisal Specialist Hospital Research Center. Out...