A5084625272- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Ion channel regulation and function
- Erythrocyte Function and Pathophysiology
- T-cell and B-cell Immunology
- Escherichia coli research studies
- CAR-T cell therapy research
- Cancer Research and Treatments
- Cytomegalovirus and herpesvirus research
- Microfluidic and Bio-sensing Technologies
- Virus-based gene therapy research
University of Freiburg
2022-2025
Austrian Centre of Industrial Biotechnology (Austria)
2022
<title>Abstract</title> Purpose Abnormal glycosylation has been long considered a hallmark of cancer progression. Carbohydrate-binding proteins, also known as lectins, offer unique way to target changes in malignant cells. The present study repurposes SadP, lectin from <italic>Streptococcus suis</italic>, globotriaosylceramide (Gb3), glycosphingolipid overly abundant many types including Burkitt’s lymphoma. SadP was genetically fused scFv an anti-CD3 antibody, resulting bispecific T cell...
Abstract The link between cancer and aberrant glycosylation has recently become evident. Glycans their altered forms, known as tumour-associated carbohydrate antigens (TACAs), are diverse, complex difficult to target therapeutically. Lectins naturally occurring glycan-binding proteins that offer a unique opportunity recognise TACAs. T cells expressing chimeric antigen receptors (CARs) have proven be successful immunotherapy against leukaemias, but so far shown limited success in solid...
Aberrant glycosylation patterns play a crucial role in the development of cancer cells as they promote tumor growth and aggressiveness. Lectins recognize carbohydrate antigens attached to proteins lipids on cell surfaces represent potential tools for application diagnostics therapy. Among emerging therapies, immunotherapy has become promising treatment modality various hematological solid malignancies. Here we present an approach redirect immune system into fighting by targeting altered...
In recent years, receptor-mediated drug delivery has gained major attention in the treatment of cancer. The pathogen-derived Shiga Toxin B subunit (STxB) can be used as a carrier that detects tumor-associated glycosphingolipid globotriaosylceramide (Gb3) receptors. While conjugation via lysine or cysteine offers random attachment to carriers, click chemistry potential improve engineering systems site specificity eliminate interference with active binding tumor ligands. We present production...
Aberrant glycosylation plays a crucial role in tumour progression and invasiveness. Tumour-associated carbohydrate antigens (TACAs) represent valuable set of targets for immunotherapeutic approaches. The poor immunogenicity glycan structures, however, requires more effective well-directed way targeting TACAs on the surface cancer cells than antibodies. glycosphingolipid globotriaosylceramide (Gb3) is well-established TACA present multitude types. Its overexpression has been linked to...
<title>Abstract</title> Infections with the Gram-negative opportunistic pathogen <italic>Pseudomonas aeruginosa</italic> are becoming increasingly difficult to treat due growing antibiotic resistance. Complications often include disturbed wound healing and impaired cell migration of various types, including epithelial immune cells in host tissue. One bacterial virulence factor responsible for these effects is carbohydrate-binding lectin LecB. It mediates adhesion cells, alters cellular...
Abstract Background Aberrant glycosylation patterns play a crucial role in the development of cancer cells as they promote tumor growth and aggressiveness. Lectins recognize carbohydrate antigens attached to proteins lipids on cell surfaces represent potential tools for application diagnostics therapy. Among emerging therapeutic strategies, immunotherapy has become promising treatment modality various hematological solid malignancies. Here we present an approach redirect immune system into...