A5055691281- Head and Neck Cancer Studies
- Thyroid Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Thyroid and Parathyroid Surgery
- Lung Cancer Treatments and Mutations
- Ear and Head Tumors
- Head and Neck Surgical Oncology
- Cancer Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Tracheal and airway disorders
- Lung Cancer Diagnosis and Treatment
- Medical and Biological Sciences
- Esophageal Cancer Research and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Cervical Cancer and HPV Research
- Lung Cancer Research Studies
- Advances in Oncology and Radiotherapy
- Radiomics and Machine Learning in Medical Imaging
- BRCA gene mutations in cancer
- Otolaryngology and Infectious Diseases
- Military History and Strategy
- Intracerebral and Subarachnoid Hemorrhage Research
- Soft tissue tumors and treatment
- Healthcare Policy and Management
NHS Lothian
2018-2024
University of Edinburgh
2020-2024
St John's Hospital
2023
Western General Hospital
2020-2022
Memorial Sloan Kettering Cancer Center
2015-2021
Edinburgh Cancer Research
2020
British Association of Endocrine and Thyroid Surgeons
2017
Fred Hutch Cancer Center
2013
Lambeth Hospital
2010
St Thomas' Hospital
2010
Minor salivary gland carcinomas of the head and neck are rare cancers with variable clinical behavior. This study explored incidence, pathology, behavior, factors predictive outcomes in a large cohort patients treated at Memorial Sloan Kettering Cancer Center over 30-year period (1985-2015).Clinical, pathological, treatment, outcome data were collected. Unadjusted adjusted hazard ratios for each calculated univariate multivariable Cox regression survival recurrence outcomes.Four hundred...
Head and neck squamous cell carcinoma (HNSCC) is characterized by significant genomic instability that could lead to clonal diversity. Intratumor heterogeneity has been proposed as a major attribute underlying tumor evolution, progression, resistance chemotherapy radiation. Understanding genetic treatments specific resistant metastatic cells. To characterize the degree of intratumor within single tumor, we performed whole-genome sequencing on three separate regions an human papillomavirus...
Background Distant metastases (DMs) are the primary cause of treatment failure in patients with salivary gland carcinoma. There is no consensus on standard treatment. Methods Patients DMs were identified from an institutional database 884 cancer who underwent resection tumor between 1985 and 2015. Survival outcomes for determined Kaplan‐Meier method. Univariate multivariate analyses performed to identify factors associated DM. Results Of identified, 137 (15%) developed during follow‐up. Most...
Background To report our experience of postoperative haemorrhage in patients following transoral robotic surgery ( TORS ). Methods Data were collected on having . Postoperative within 30 days was graded using the Mayo Clinic grading system. Results Transoral operations performed 122 patients. There 23 bleeding events classified as minor to severe 19 (16%). Haemorrhage requiring a return operating room occurred after 7 (6%). The odds an emergent 5.19 times greater who had staged neck...
IntroductionOropharyngeal squamous cell carcinoma (OPSCC) is increasing in global prevalence and divided into two types dependent on association with human papillomavirus (HPV). Assay of HPV copy number plasma cell-free DNA (cfDNA) provides a minimally invasive method for detecting monitoring tumour-derived HPV, potential enhancing clinical care.Materials methodsIn prospectively recruited cohort 104 OPSCC patients, we evaluate the utility cfDNA droplet digital PCR (ddPCR) as characterisation...
Oropharyngeal squamous cell carcinoma (OPSCC) is an increasing health problem in the developing and developed world. In recent years, there have been major changes treatment paradigms for OPSCC. This because of a number reasons: understanding discovery new viral etiology (the human papillomavirus [HPV]), practice patterns owing to advances radiotherapy, then organ preservation strategy with increased use chemotherapy. Next came development surgical technologies emergence modality,...
Abstract Background The purpose of this study was to investigate the performance Memorial Sloan Kettering Cancer Center salivary carcinoma nomograms predicting overall survival, cancer‐specific and recurrence with an external validation dataset. Methods dataset comprised 123 patients treated between 2010 2015 at our institution. They were evaluated by assessing discrimination (concordance index [C‐index]) calibration (plotting predicted vs actual probabilities for quintiles). Results cohort...
In our experience, fine needle aspiration cytology (FNAC) combined with immunocytochemistry/flow cytometry in the investigation of lymphoma presenting neck is highly valuable. unit it has a sensitivity 95.5% and positive predictive value (PPV) 96.8% first-line suspected lymphoma. It enables planning radiological haematological investigations obviates panendoscopy as part staging protocol.Lymphoma commonly presents to otolaryngologists. The aim study was evaluate accuracy FNAC at...
Total laryngectomy is often utilised to manage squamous cell carcinoma of the larynx or hypopharynx. This study reports on surgical trends and outcomes over a 10-year period.A retrospective review patients undergoing total for was performed (n = 173), dividing into primary salvage cohorts.A shift towards organ-sparing management observed. Primary locoregionally advanced disease reconstruction less than laryngectomy. Overall, 11 per cent developed pharyngocutaneous fistulae (primary: 6 cent;...
<h3>Importance</h3> Salivary gland cancer comprises a diverse group of histologic types with different biological behavior. Owing to this heterogeneity, the association margin status and postoperative adjuvant radiotherapy has been poorly studied. <h3>Objective</h3> To examine between surgical oncologic outcomes subsequent outcome in patients salivary carcinomas. <h3>Design, Setting, Participants</h3> This cohort study analyzed data from institutional records at Memorial Sloan Kettering...
The incidence of thyroid cancer is increasing globally due to the increase in detection subclinical, low volume papillary microcarcinomas (PTMC) (<1 cm). Several international groups have recommended an active surveillance approach for this low-risk disease. In contrast many other countries, United Kingdom's (UK's) nodules avoid incidental lesions where appropriate.This study aims establish proportion patients with UK that would benefit from surveillance.Individuals PTMC NHS Lothian...