A5021168546- Biomedical and Engineering Education
- Science, Research, and Medicine
- Pregnancy and preeclampsia studies
- Cellular transport and secretion
- Cardiomyopathy and Myosin Studies
- Genetics, Bioinformatics, and Biomedical Research
- Cellular Mechanics and Interactions
- Pregnancy and Medication Impact
- Reproductive System and Pregnancy
- Muscle Physiology and Disorders
- Genetic and Kidney Cyst Diseases
- Genetic Syndromes and Imprinting
- Prenatal Screening and Diagnostics
- Ubiquitin and proteasome pathways
- Genetics, Aging, and Longevity in Model Organisms
- Cardiac electrophysiology and arrhythmias
- Renal and related cancers
- Birth, Development, and Health
- Connexins and lens biology
- Peptidase Inhibition and Analysis
- Hedgehog Signaling Pathway Studies
- Cardiovascular Effects of Exercise
- Nuclear Structure and Function
- Health, Environment, Cognitive Aging
- Cell Adhesion Molecules Research
Friedrich Miescher Institute
2023-2024
IFOM
2016-2021
European School of Molecular Medicine
2018
San Raffaele University of Rome
2014
In humans, balanced invasion of trophoblast cells into the uterine mucosa, decidua, is critical for successful pregnancy. Evidence suggests that this process regulated by natural killer (uNK) cells, but how they influence reproductive outcomes unclear. Here, we used our organoids and primary tissue samples to determine uNK affect placentation. By locating potential interaction axes between using single-cell transcriptomics in vitro modeling these interactions organoids, identify a...
Cell migration during development and metastatic invasion requires the coordination of actin adhesion dynamics to promote protrusive activity at cell front. The knowledge molecular mechanisms required achieve such is fragmentary. Here we identify a new functional complex that drives motility. adaptor proteins ERC1a LL5 are with liprin-α1 for effective tumor invasion, do so by stabilizing Depletion either protein negatively affects on extracellular matrix, lamellipodial persistence, as well...
Myosin VI is critical for cargo trafficking and sorting during early endocytosis autophagosome maturation, abnormalities in these processes are linked to cancers, neurodegeneration, deafness, hypertropic cardiomyopathy. We identify a structured domain myosin VI, ubiquitin-binding (MyUb), that binds ubiquitin chains, especially those via K63, K11, K29. Herein, we solve the solution structure of MyUb MyUb:K63-linked diubiquitin. folds as compact helix-turn-helix-like motif nestles between...
Desmoplakin (DP) is an obligate component of desmosomes, intercellular adhesive junctions that maintain the integrity epidermis and myocardium. Mutations in DP can cause cardiac cutaneous disease, including arrhythmogenic cardiomyopathy (ACM), inherited disorder frequently results deadly arrhythmias. Conduction defects ACM are linked to remodeling functional interference with Cx43-based gap electrically chemically couple cells. How loss impairs poorly understood. We show prevents...
The actin motor protein myosin VI is a multivalent with diverse functions.Here, we identified and characterised ubiquitous interactor, the oral-facial-digital syndrome 1 (OFD1) protein, whose mutations cause malformations of face, oral cavity, digits polycystic kidney disease.We found that regulates localisation OFD1 at centrioles and, as consequence, recruitment distal appendage Cep164.Myosin depletion in non-tumoural cell lines causes an aberrant along centriolar walls, which due to...
Summary Fetal growth and development during human pregnancy depends on delivery of adequate maternal oxygen nutrients to the fetus via placenta. In humans, balanced invasion fetal placental trophoblast cells into uterine lining, where they interact with natural killer (uNK), is thought be critical for a successful but exactly how this influences reproductive outcomes remains undefined. Here, we used our organoid model primary tissue samples determine uNK affect placentation. By locating...
Abstract The actin motor protein myosin VI is a multivalent with diverse functions. Here, we identified and characterised ubiquitous interactor, the oral-facial-digital syndrome 1 (OFD1) protein, whose mutations cause malformations of face, oral cavity, digits, polycystic kidney disease. We found that regulates localisation OFD1 at centrioles and, as consequence, recruitment distal appendage cep164. Myosin depletion in non-tumoural cell lines causes an aberrant along centriolar walls, which...
The EUROPEAN ACADEMY FOR BIOMEDICAL SCIENCE (ENABLE) is an initiative funded by the European Union Horizon 2020 program involving four renowned research institutes (Institute for Research in Biomedicine—IRB Barcelona, Spain; Radboud Institute Molecular Life Sciences—RIMLS, Netherlands; Novo Nordisk Foundation Center Protein Research—NNF CPR, Denmark; School of Medicine—SEMM, Italy) and innovative science communication agency (Scienseed). With aim to promote biomedical excellence Europe,...
The EUROPEAN ACADEMY FOR BIOMEDICAL SCIENCE (ENABLE) is an initiative funded by the European Union Horizon 2020 program involving four renowned Research Institutes (Institute for in Biomedicine—IRB Barcelona, Spain; Radboud Institute Molecular Life Sciences—RIMLS, Netherlands; Novo Nordisk Foundation Center Protein Research—NNF CPR, Denmark; School of Medicine—SEMM, Italy) and innovative science communication agency (Scienseed). With aim promoting biomedical excellence Europe, ENABLE...
The European Academy for Biomedical Science (ENABLE) is an initiative funded by the Union Horizon 2020 program involving four renowned Research Institutes (Institute in Biomedicine—IRB Barcelona, Spain; Radboud Institute Molecular Life Sciences—RIMLS, Netherlands; Novo Nordisk Foundation Center Protein Research—NNF CPR, Denmark; School of Medicine—SEMM, Italy) and innovative science communication agency (Scienseed). With aim promoting biomedical excellence Europe, ENABLE organizes annual...
The European Academy for Biomedical Science (ENABLE) is an initiative funded by the Union Horizon 2020 program involving four renowned Research Institutes (Institute in Biomedicine—IRB Barcelona, Spain; Radboud Institute Molecular Life Sciences—RIMLS, Netherlands; Novo Nordisk Foundation Center Protein Research—NNF CPR, Denmark; School of Medicine—SEMM, Italy) and innovative science communication agency (Scienseed). With aim promoting biomedical excellence Europe, ENABLE organizes annual...