The intestinal microflora affects inflammation and immunity, not only locally at the mucosal level but also systemically, raising question of whether inflammatory processes that contribute to cancer its therapy. Prebiotics have been found play an antitumor role is limited gut. We investigated roles microbiota using Lewis lung mouse model. In mice treated with cisplatin combined ABX (an antibiotic cocktail vancomycin, ampicillin, neomycin), which can destroy host commensal microflora, tumor...

Path planning for multiple unmanned surface vehicles (USVs) in task is a high-complexity problem. When the number of USVs n, computational complexity usually as high On2, paths need to be planned from different start points target points. In this paper, we propose low-complexity path-planning algorithm (LCPP) based on visibility graph method. First, all between points, and obstacle vertices are separately with On. After that, Dijkstra employed find shortest path each point also To enhance...

Summary Rare earth elements (REE) have been shown to influence growth performance in animal production, especially pigs. In the present study, effect of oral administration rare on growing rats was investigated. Pure LaCl 3 or an REE mixture containing 38% , 52% CeCl 3% PrCl and 7% chlorides other were used at two different concentrations as supplements diets. Fifty male Wistar 4 weeks age allotted five experimental groups: a control group; La‐low group La‐high with 75 150 mg/kg ·6H 2 O,...

The study was conducted to evaluate the effect of chromium nanoparticle (CrNano) on growth, carcass characteristics, pork quality, and tissue in finishing pigs.A total 100 Duroc×Landrace×Yorkshire barrows (average initial BW 64.78±0.83kg) were divided into 10 pens, pigs per pen. 5 pens fed with control diet (corn-soybean meal, 1.05% Lys) others addition 200 µg/kg Chrome (Cr) from CrNano.During trial, all given free access feed water.After 35 days each treatment (weight similar average group...

This experiment was conducted to investigate the effect of arsenic (As III ) on lipid peroxidation, glutathione content and antioxidant enzymes in growing pigs.Ninety-six Duroc-Landrace-Yorkshire crossbred pigs (48 barrows 48 gilts, respectively) were randomly assigned four groups each group three pens (four gilts).The received same corn-soybean basal diet which supplemented with 0, 10, 20, 30 mg/kg As respectively.Arsenic added form 2 O 3 .The lasted for seventy-eight days after a seven-day...

Task allocation of unmanned surface vehicles (USVs) with low task cost is an important research area which assigns USVs from starting points to different target complete tasks. Most the lines are using heuristic algorithms obtain suboptimal solutions reduce both max and total cost. In practice, reducing maximum more time, departure last USV arriving at designated position. this paper, exact algorithm proposed minimize time based on Hungarian algorithm. algorithm, composed travel along...

A feeding trial was conducted on pigs to study the effect of La their growth performance. Sixty barrows were randomly assigned two groups (each which included three replicates) and they fed same basal diet supplemented with 0 or 100 mg/kg lanthanum (La) respectively for 30 d. Blood samples collected analyzed hormone secretion pattern. residues in selected organs test safety level. The results showed that average daily gain feed conversion ratio increased by 12.95% (p<0.05) 6.78%...

In the era of noisy intermediate-scale quantum (NISQ) computing, synergistic collaboration between and classical computing models has emerged as a promising solution for tackling complex computational challenges. Long short-term memory (LSTM), popular network modeling sequential data, been widely acknowledged its effectiveness. However, with increasing demand data spatial feature extraction, training cost LSTM exhibits exponential growth. this study, we propose convolutional long (QConvLSTM)...

The study was conducted to investigate the effect of chromium nanocomposite (CrNano) on growth hormone (GH) pulsatile secretion and pituitary GH mRNA expression in finishing pigs. Fifty-four crossbred pigs (65.57 ± 1.05 kg initial weight) were randomly allotted one three treatments, with replicate pens per treatment six pen. Pigs offered four diets including a control diet or supplemented 200 μg/kg from either chloride (CrCl3) CrNano for 35 days. During trial, all given free access feed...

Three trials were conducted with 216 Yorkshire × Duroc Hampshire crossbred pigs (equal males and females) weaned at 3 to 4 wk of age (avg 7.4 kg initially) determine the effectiveness aspirin in an 18% CP corn-soybean meal starter diet (with without soybean oil Trial III) for improving postweaning performance reducing scours. When levels common all (0, 250 ppm) or Trials II III 125 compared, improvements ADG (P < .10) daily feed intake .05) observed no effect on efficiency utilization. There...

The purpose of the present study was to investigate effects chromium picolinate (CrPic) on growth hormone (GH) secretion and pituitary GH mRNA expression in finishing pigs.Forty eight crossbred pigs with an initial body weight 65.57kg (SD = 1.05) were blocked by randomly assigned two treatments three replicates.Each group fed diet supplemented or without 200 μg/kg from CrPic for 40 days.The results showed that average daily gain increased 9.84% (p<0.05), longissimus muscle area 17.29%...

Resistance to osimertinib represents a significant challenge for the successful treatment of non-small cell lung cancer (NSCLC) harboring activating mutations in EGFR. N6-methyladenosine (m6A) on mRNAs is critical various biological processes, yet whether m6A regulates resistance NSCLC remains unknown. In this study, we demonstrated that developing osimertinib-resistant phenotypes depends reduction resulting from downexpression methyltransferase METTL14 EGFR-mutant NSCLCs. Both vitro and...

The slaughtering environment is crucial for the food hygiene and safety of poultry products. Despite global dominance industrial processing, live bird in wet markets persists due to cultural, religious, economic reasons. This study aims reveal correlation between scales bacterial contamination levels on broiler carcasses, with a particular focus pathobiont transmission risks microbiome characteristics. Wet were categorized based home-made ratings Hygiene Biosecurity Assessment Tool (HABT)....

&lt;p&gt;S1. The validation of resistance to third-generation TKIs osimertinib, furmonertinib and almonertinib in osimertinib-resistant NSCLC cells.&lt;/p&gt;

&lt;p&gt;S7. The effect of METTL3 on m6A-modified Bim mRNA.&lt;/p&gt;

&lt;div&gt;Abstract&lt;p&gt;Resistance to osimertinib represents a significant challenge for the successful treatment of non–small cell lung cancer (NSCLC) harboring activating mutations in &lt;i&gt;EGFR&lt;/i&gt;. N6-methyladenosine (m&lt;sup&gt;6&lt;/sup&gt;A) on mRNAs is critical various biological processes, yet whether m&lt;sup&gt;6&lt;/sup&gt;A regulates resistance NSCLC remains unknown. In this study, we demonstrated that developing osimertinib-resistant phenotypes depends reduction...

&lt;p&gt;S2. The effect of METTL14 knockdown on cell proliferation H1975 and PC9 cells.&lt;/p&gt;

&lt;p&gt;S6. METTL14-mediated m6A methylation of Bim mRNA maintains its stability and increases expression.&lt;/p&gt;

&lt;p&gt;S3. The effect of METTL3 on the osimertinib sensitivity NSCLC cells.&lt;/p&gt;

&lt;p&gt;S4. METTL14 promotes osimertinib-induced cell apoptosis in NSCLC cells.&lt;/p&gt;

&lt;p&gt;S5. METTL14 promotes cell apoptosis in NSCLC cells.&lt;/p&gt;

ABSTRACT To address the issue of underreporting faults in detection tiny by dynamic factor analysis (DFA), a novel fault and diagnosis method based on DFA‐sliding window combined with mean square error (DFA‐SWMSE) is proposed. Firstly, data matrix augmented introducing time lag shifts. Secondly, (FA) applied to matrix, achieving dimensionality reduction feature extraction while retaining most original data's information. Then, sliding technique calculate dimensionally reduced data, allowing...

The rise of online meal delivery has led to a surge in traffic urban neighborhoods, resulting issues such as increased congestion, illegal parking, noise, and air pollution. This paper introduces analyzes novel strategy that incorporates microhub. In this approach, the service area is segmented into smaller sub-areas, with deliverers assigned operate exclusively within these sub-areas. microhub functions transfer depot, enabling batching orders toward different To evaluate system's...