A5103207974- Molecular Sensors and Ion Detection
- Crystallization and Solubility Studies
- Luminescence and Fluorescent Materials
- Enzyme Structure and Function
- X-ray Diffraction in Crystallography
- Advanced biosensing and bioanalysis techniques
- Supramolecular Chemistry and Complexes
- Diabetes and associated disorders
- Metal-Organic Frameworks: Synthesis and Applications
- Evolutionary Psychology and Human Behavior
- Blood groups and transfusion
- RNA Interference and Gene Delivery
- Genetic Associations and Epidemiology
- Genetic factors in colorectal cancer
- DNA and Nucleic Acid Chemistry
- Amino Acid Enzymes and Metabolism
- Biochemical and Molecular Research
- Genomics and Rare Diseases
- Morphological variations and asymmetry
- Diet and metabolism studies
- Supramolecular Self-Assembly in Materials
- Bacteriophages and microbial interactions
- Analytical Chemistry and Sensors
- Hemispheric Asymmetry in Neuroscience
- Erythrocyte Function and Pathophysiology
Wuhan University
2023
Beijing Normal University
2019-2021
Torrey Pines Institute For Molecular Studies
2004
Brandeis University
2004
Warneford Hospital
2002
Abstract Host-guest complex solid state molecular motion is a critical but underexplored phenomenon. In principle, it can be used to control machines that function in the state. Here we describe system operates on basis of complexation between an all-hydrocarbon macrocycle, D 4d -CDMB-8 , and perylene. Molecular this machine induced by exposure organic solvents or grinding gives rise different co-crystalline, mixed crystalline, amorphous forms. Distinct time-dependent emissive responses are...
A new approach to anion sensing that involves excimer disaggregation induced emission (EDIE) is reported. It the anion-mediated of formed from a cationic macrocycle. This leads an increase in observed fluorescence intensity. The macrocycle question, cyclo[1]N2,N6-dimethyl-N2,N6-bis(6-(1H-imidazolium-1-yl)pyridin-2-yl)pyridine-2,6-diamine[1]1,4-dimethylbenzene (12+; prepared as its PF6– salt), obtained ca. 70% yield via simple cyclization. X-ray diffraction analyses single crystals revealed...
Substituent effects play critical roles in both modulating reaction chemistry and supramolecular self-assembly processes. Using substituted terephthalate dianions (p-phthalic acid dianions; PTADAs), the effect of varying type, number, position substituents was explored terms their ability to regulate inherent anion complexation features a tetracationic macrocycle, cyclo[2](2,6-di(1H-imidazol-1-yl)pyridine)[2](1,4-dimethylenebenzene) (referred as Texas-sized molecular box; 14+), form its...
3-Carboxy-cis,cis-muconate lactonizing enzymes (CMLEs), the key in protocatechuate branch of β-ketoadipate pathway microorganisms, catalyze conversion 3-carboxy-cis,cis-muconate to muconolactones. We have determined crystal structure prokaryotic Pseudomonas putida CMLE (PpCMLE) at 2.6 Å resolution. PpCMLE is a homotetramer and belongs fumarase class II superfamily. The active site formed largely by three regions, which are moderately conserved superfamily, from respective monomers. It has...
Abstract A case (based upon an association with cerebral asymmetry) has been presented for a gene psychosis within the Xq21.3/Yp region of homology that is specific to Homo sapiens . We tested this hypothesis using pentanucleotide marker DXYS 156 located region. In 84 families affected by schizophrenia or schizo‐affective disorder no tendency toward increased allele sharing amongst siblings was observed (χ 2 = 0.002). conclude either does not include predisposing if it does, relevant...
Macrocycle, cyclo[4] [(1,3-(4,6)-dimethylbezene)[4](2,6-(3,5)-dimethylpyridine (B4P4), shows highly selective binding affinity with protirelin (Pyr-His-Pro-NH2 ; TRH) among the tested 26 drug or adductive substrates. The stable complexation in a 1:1 manner was fully characterized solution, gas phase, and solid state study. Furthermore, B4P4 acts as an efficient TRH inhibitor even at [macrocycle]:[drug] <1:300, both membrane transport cellar incubation. current work provides unprecedented...
DNA small molecular probe study was considered as a promising approach to achieve related disease diagnosis. Most reports were performed under specific salinity. Herein, 4-imino-3-(pyridin-2-yl)-4H-quinolizine-1-carbonitrile (IPQC) generated via facile procedure with high yield (85%). It is found that IPQC could act universal for most tested ssDNA, dsDNA and G4 in low [K+] concentration (less than 20 mM). However, showed highly selective binding UV-vis fluorescence response increasing (e.g.,...
Objective: To screen the candidate genes in a patient with Kabuki syndrome (KS), providing basis for genetic counseling, prenatal screening, diagnosis and facilitating early treatment. Methods: This study included 16-year-old female KS born of non-consanguineous Chinese parents who presented to Department Orthognathic & Cleft Lip Palate Plastic Surgery, School Hospital Stomatology, Wuhan University. Genomic DNA was extracted from peripheral blood subjects analyzed by whole-exome sequencing...