A5087199395- Toxoplasma gondii Research Studies
- Herpesvirus Infections and Treatments
- Immunotherapy and Immune Responses
- Synthetic Organic Chemistry Methods
- Cholinesterase and Neurodegenerative Diseases
- Cancer Treatment and Pharmacology
- Pneumonia and Respiratory Infections
- Data-Driven Disease Surveillance
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Parkinson's Disease Mechanisms and Treatments
- Psychosocial Factors Impacting Youth
- Enzyme Catalysis and Immobilization
- Neuroinflammation and Neurodegeneration Mechanisms
- Chemical Synthesis and Analysis
- Antibiotic Use and Resistance
- Cytomegalovirus and herpesvirus research
Public Health Agency of Sweden
2017
Stockholm University
2017
Swedish Institute
2011-2013
École Polytechnique Fédérale de Lausanne
2013
Karolinska University Hospital
2012-2013
Karolinska Institutet
2011-2012
During acute infection in human and animal hosts, the obligate intracellular protozoan Toxoplasma gondii infects a variety of cell types, including leukocytes. Poised to respond invading pathogens, dendritic cells (DC) may also be exploited by T. for spread infected host. Here, we report that mouse myeloid DC possess functional γ-aminobutyric acid (GABA) receptors machinery GABA biosynthesis secretion. Shortly after (genotypes I, II III), responded with enhanced secretion vitro. We...
Disseminated toxoplasmosis in the central nervous system (CNS) is often accompanied by a lethal outcome. Studies with murine models of infection have focused on role systemic immunity control toxoplasmic encephalitis, while knowledge remains limited contributions resident cells immune functions CNS. In this study, glial was addressed setting recrudescent Toxoplasma mice. Activated astrocytes and microglia were observed close vicinity foci replicating parasites situ brain parenchyma. gondii...
Host cell manipulation is an important feature of the obligate intracellular parasite Toxoplasma gondii. Recent reports have shown that tachyzoite stages subvert dendritic cells (DC) as a conduit for dissemination (Trojan horse) during acute infection. To examine cellular basis these processes, we performed detailed analysis early events following invasion human monocyte-derived DC. We demonstrate within minutes after penetration, profound morphological changes take place in DC coincide with...
The obligate intracellular parasite Toxoplasma gondii exploits cells of the immune system to disseminate. Upon T. gondii-infection, γ-aminobutyric acid (GABA)/GABAA receptor signaling triggers a hypermigratory phenotype in dendritic (DCs) by unknown signal transduction pathways. Here, we demonstrate that calcium (Ca2+) DCs is indispensable for gondii-induced DC hypermotility and transmigration vitro. We report activation GABAA receptors GABA induces transient Ca2+ entry DCs. Murine bone...
Post-translational modifications (PTMs) regulate key aspects of the physiological and pathogenic properties Parkinson's disease-associated presynaptic protein α-synuclein. We herein describe a one-pot total chemical synthesis that should enable site-specific introduction single or multiple PTMs small molecule probes essentially at any site within protein.
The obligate intracellular parasite Toxoplasma gondii can actively infect any nucleated cell type, including cells from the immune system. rapid transfer of T. infected dendritic to effector natural killer (NK) may contribute parasite's sequestration and shielding recognition shortly after infection. However, subversion NK functions, such as cytotoxicity or production proinflammatory cytokines, gamma interferon (IFN-γ), upon infection might also be beneficial parasite. In present study, we...